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PCSK1 Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 5122 proprotein convertase subtilisin/kexin type 1 chr5 - 95767363 - 95773985 95767863 Transcription Factor Binding Sites   Download all TFBS in the PCSK1 promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints FOXJ2_forkhead_DBD_dimeric_13_1 SELEX - 95763766 95763778 8.0E-06 AGAAACAACAACA 13 E2F3_E2F_DBD_dimeric_18_2 SELEX + 95767511 95767528 0.0E+00 AAAAAACGCGCCAAAATG 18 E2F3_E2F_DBD_dimeric_18_2 SELEX - 95767511 95767528 1.0E-06 CATTTTGGCGCGTTTTTT 18 Hoxd9_homeodomain_DBD_monomeric_10_1 SELEX + 95766791 95766800 4.0E-06 ACAATTAAAT 10 SOX10_HMG_full_dimeric_15_3 SELEX + 95767169 95767183 4.0E-06 ATCAGTTGCAATCAT 15 NFIA_NFI_full_dimeric_15_1 SELEX + 95768029 95768043 8.0E-06 CTGGCACTCTTCCAA 15 NFIA_NFI_full_dimeric_15_1 SELEX - 95768029 95768043 2.0E-06 TTGGAAGAGTGCCAG 15 BARX1_homeodomain_DBD_dimeric_17_1 SELEX - 95768379 95768395 6.0E-06 GCATTATTTACTGTTTA 17 POU3F3_POU_DBD_monomeric_12_1 SELEX - 95768386 95768397 1.0E-06 TTGCATTATTTA 12 LHX6_homeodomain_full_dimeric_16_1 SELEX - 95767167 95767182 3.0E-06 TGATTGCAACTGATTG 16 POU3F2_POU_DBD_monomeric_13_1 SELEX - 95768386 95768398 1.0E-06 CTTGCATTATTTA 13 NR2E1_nuclearreceptor_full_monomeric_9_1 SELEX - 95767030 95767038 7.0E-06 AGAAGTCAA 9 LHX2_homeodomain_DBD_dimeric_15_1 SELEX + 95767152 95767166 1.0E-06 TGATTACACAAATTA 15 SOX9_HMG_full_dimeric_17_3 SELEX + 95767168 95767184 5.0E-06 AATCAGTTGCAATCATT 17 ZNF75A_C2H2_DBD_monomeric_12_1 SELEX + 95766960 95766971 0.0E+00 TGTTTTCCCACA 12 POU3F4_POU_DBD_monomeric_11_1 SELEX - 95768386 95768396 1.0E-06 TGCATTATTTA 11 NR2F6_nuclearreceptor_full_dimeric_14_1 SELEX - 95767024 95767037 9.0E-06 GAAGTCAAAGGTTG 14 Lhx8_homeodomain_DBD_dimeric_12_1 SELEX + 95767161 95767172 1.0E-06 AAATTACAATCA 12 Lhx8_homeodomain_DBD_dimeric_12_1 SELEX - 95767161 95767172 3.0E-06 TGATTGTAATTT 12 SOX8_HMG_full_dimeric_17_1 SELEX + 95767168 95767184 3.0E-06 AATCAGTTGCAATCATT 17 PAX5_PAX_DBD_monomeric_18_1 SELEX - 95767465 95767482 0.0E+00 AGTCACGGATGAGTAATC 18 NFIX_NFI_full_dimeric_15_2 SELEX + 95768029 95768043 1.0E-06 CTGGCACTCTTCCAA 15 NFIX_NFI_full_dimeric_15_2 SELEX - 95768029 95768043 7.0E-06 TTGGAAGAGTGCCAG 15 BARX1_homeodomain_DBD_monomeric_8_1 SELEX + 95766791 95766798 5.0E-06 ACAATTAA 8 EBF1_MA0154.1 JASPAR - 95767637 95767646 6.0E-06 ACCCTAGGGA 10 PAX2_PAX_DBD_monomeric_18_1 SELEX - 95767465 95767482 0.0E+00 AGTCACGGATGAGTAATC 18 E2F2_E2F_DBD_dimeric_16_1 SELEX + 95767512 95767527 1.0E-06 AAAAACGCGCCAAAAT 16 E2F2_E2F_DBD_dimeric_16_1 SELEX - 95767512 95767527 1.0E-06 ATTTTGGCGCGTTTTT 16 PAX1_PAX_DBD_monomeric_17_1 SELEX - 95767466 95767482 1.0E-06 AGTCACGGATGAGTAAT 17 IRF7_IRF_DBD_trimeric_17_1 SELEX - 95767341 95767357 6.0E-06 GAAAGGAAAATCAATGC 17 HOMEZ_HOMEZ_DBD_monomer-or-dimer_12_1 SELEX + 95767772 95767783 7.0E-06 AAAACGATTACG 12 FOXD2_forkhead_DBD_dimeric_14_1 SELEX + 95767047 95767060 5.0E-06 AGCAAATGTTTTCT 14 FOXD2_forkhead_DBD_dimeric_14_1 SELEX - 95767047 95767060 2.0E-06 AGAAAACATTTGCT 14 Pax4_MA0068.1 JASPAR + 95767524 95767553 9.0E-06 AAATGTTTTACAACTGCCTCCTCCCACGCT 30 Egr1_C2H2_mouse-DBD_mutant_DBD_monomeric_16_1 SELEX + 95767692 95767707 7.0E-06 TGACGCCCACCCACCT 16 FOXD3_forkhead_DBD_dimeric_14_1 SELEX + 95767047 95767060 5.0E-06 AGCAAATGTTTTCT 14 FOXD3_forkhead_DBD_dimeric_14_1 SELEX - 95767047 95767060 2.0E-06 AGAAAACATTTGCT 14 SOX8_HMG_full_dimeric_13_1 SELEX - 95767622 95767634 1.0E-05 GTGACTTCTAGTC 13 NKX3-1_homeodomain_full_monomeric_9_1 SELEX + 95767678 95767686 5.0E-06 CCCACTTAA 9 FOXJ3_forkhead_DBD_dimeric_14_1 SELEX + 95768378 95768391 2.0E-06 CTAAACAGTAAATA 14 FOXO4_forkhead_DBD_putatively-multimeric_12_1 SELEX + 95766962 95766973 8.0E-06 TTTTCCCACAAG 12 ONECUT2_CUT_DBD_monomeric_14_1 SELEX - 95767340 95767353 9.0E-06 GGAAAATCAATGCA 14 znf143_MA0088.1 JASPAR + 95767541 95767560 5.0E-06 CTCCTCCCACGCTTCAATGC 20 PAX9_PAX_DBD_monomeric_17_1 SELEX - 95767466 95767482 1.0E-06 AGTCACGGATGAGTAAT 17 POU3F1_POU_DBD_monomeric_12_2 SELEX - 95768386 95768397 1.0E-06 TTGCATTATTTA 12 NFIB_NFI_full_dimeric_15_1 SELEX + 95768029 95768043 9.0E-06 CTGGCACTCTTCCAA 15 NFIB_NFI_full_dimeric_15_1 SELEX - 95768029 95768043 1.0E-06 TTGGAAGAGTGCCAG 15 MEOX2_homeodomain_DBD_dimeric_17_1 SELEX + 95767151 95767167 1.0E-06 ATGATTACACAAATTAC 17 MEOX2_homeodomain_DBD_dimeric_17_1 SELEX - 95767151 95767167 5.0E-06 GTAATTTGTGTAATCAT 17 LHX6_homeodomain_full_dimeric_12_1 SELEX - 95767161 95767172 9.0E-06 TGATTGTAATTT 12 NR3C1_MA0113.1 JASPAR + 95767772 95767789 9.0E-06 AAAACGATTACGTACTTG 18 REST_MA0138.2 JASPAR - 95763730 95763750 0.0E+00 ATTAGGACCACGGACAGTGAC 21 REST_MA0138.2 JASPAR + 95770015 95770035 1.0E-05 TTCAGCACCGAGGTCTGGACA 21 FOXO1_forkhead_DBD_putatively-multimeric_12_1 SELEX + 95766962 95766973 7.0E-06 TTTTCCCACAAG 12 Foxj3_forkhead_DBD_dimeric_13_1 SELEX - 95763766 95763778 3.0E-06 AGAAACAACAACA 13 E2F2_E2F_DBD_dimeric_18_1 SELEX + 95767511 95767528 0.0E+00 AAAAAACGCGCCAAAATG 18 E2F3_E2F_DBD_dimeric_18_3 SELEX + 95767511 95767528 4.0E-06 AAAAAACGCGCCAAAATG 18 POU4F1_POU_DBD_monomeric_14_1 SELEX - 95768384 95768397 4.0E-06 TTGCATTATTTACT 14 Irx3_homeodomain_DBD_dimeric_12_1 SELEX + 95768992 95769003 7.0E-06 TTACACGTCAAA 12 E2F1_E2F_DBD_monomeric_14_1 SELEX + 95767513 95767526 8.0E-06 AAAACGCGCCAAAA 14 ONECUT3_CUT_DBD_monomeric_14_1 SELEX - 95767340 95767353 6.0E-06 GGAAAATCAATGCA 14 FOXJ2_forkhead_DBD_dimeric_14_1 SELEX + 95768378 95768391 1.0E-06 CTAAACAGTAAATA 14 V_CEBPG_Q6_M00622 TRANSFAC + 95767151 95767163 8.0E-06 ATGATTACACAAA 13 V_E2A_Q6_01_M02088 TRANSFAC - 95770099 95770111 5.0E-06 GGCCAGCTGCAGA 13 V_MSX3_01_M01341 TRANSFAC + 95766786 95766801 9.0E-06 AATACACAATTAAATC 16 V_FOXP3_Q4_M00992 TRANSFAC - 95768322 95768338 8.0E-06 GTAGGGCTTATGCTTAC 17 V_IPF1_02_M01234 TRANSFAC - 95767006 95767015 5.0E-06 ACATAATGAG 10 V_TCF3_01_M01594 TRANSFAC + 95770129 95770141 9.0E-06 CTTTTGATATGTG 13 V_EBF_Q6_M00977 TRANSFAC + 95767915 95767925 8.0E-06 CTCCCTAGAGA 11 V_POU3F3_01_M03090 TRANSFAC - 95768386 95768402 7.0E-06 AAAGCTTGCATTATTTA 17 V_HSF1_Q6_M01023 TRANSFAC - 95767416 95767432 6.0E-06 CCTCTGGGGAATTCGCC 17 V_E2F4_Q6_M02090 TRANSFAC + 95769992 95770001 1.0E-05 GCGGGAGATA 10 V_FOXA2_04_M02749 TRANSFAC + 95768380 95768396 1.0E-06 AAACAGTAAATAATGCA 17 V_RHOX11_01_M01347 TRANSFAC - 95763744 95763760 6.0E-06 ACAATGCTGTATTAGGA 17 V_NF1_Q6_01_M00806 TRANSFAC + 95767591 95767607 1.0E-05 TTGATTCCGAGCCAAGG 17 V_NF1_Q6_01_M00806 TRANSFAC + 95770242 95770258 2.0E-06 TTGGACTCAGGCCAAAA 17 V_HMGIY_Q3_M01010 TRANSFAC + 95767342 95767356 6.0E-06 CATTGATTTTCCTTT 15 V_COE1_Q6_M01871 TRANSFAC - 95767419 95767432 2.0E-06 CCTCTGGGGAATTC 14 V_IK_Q5_M01169 TRANSFAC - 95767996 95768005 8.0E-06 GTTGGGAGGC 10 V_OCTAMER_01_M01324 TRANSFAC - 95768386 95768402 7.0E-06 AAAGCTTGCATTATTTA 17 V_NFAT3_Q3_M01734 TRANSFAC + 95767345 95767354 3.0E-06 TGATTTTCCT 10 V_HNF4_Q6_M00967 TRANSFAC - 95767881 95767889 2.0E-06 AAAGTCCAA 9 V_HNF3_Q6_01_M01012 TRANSFAC - 95768379 95768396 5.0E-06 TGCATTATTTACTGTTTA 18 V_AIRE_02_M01000 TRANSFAC - 95768370 95768394 0.0E+00 CATTATTTACTGTTTAGGCTGGGCG 25 V_NR3C1_01_M02219 TRANSFAC + 95767772 95767789 9.0E-06 AAAACGATTACGTACTTG 18 V_TCFAP2E_04_M02926 TRANSFAC + 95763685 95763698 5.0E-06 AACTTGACAAAAAA 14 V_CDX_Q5_M00991 TRANSFAC + 95767370 95767387 5.0E-06 GACAATTTGGTTTATAAA 18 V_CDX_Q5_M00991 TRANSFAC - 95767380 95767397 4.0E-06 CATTCTCAACTTTATAAA 18 V_RHOX11_02_M01384 TRANSFAC - 95763744 95763760 5.0E-06 ACAATGCTGTATTAGGA 17 V_NRSE_B_M00325 TRANSFAC - 95763730 95763750 1.0E-06 ATTAGGACCACGGACAGTGAC 21 V_BCL6_02_M01185 TRANSFAC - 95769002 95769015 2.0E-06 GGCTTTCGTCGATT 14 V_WT1_Q6_01_M02036 TRANSFAC + 95767455 95767464 4.0E-06 CGCCCCCGCC 10 V_TST1_01_M00133 TRANSFAC - 95767239 95767253 8.0E-06 GAGGAATAAGAGGAG 15 V_HELIOSA_02_M01004 TRANSFAC - 95770123 95770133 2.0E-06 AAAAGGAAAAC 11 V_POU3F2_01_M00463 TRANSFAC - 95768384 95768397 9.0E-06 TTGCATTATTTACT 14 V_FREAC3_01_M00291 TRANSFAC + 95768380 95768395 3.0E-06 AAACAGTAAATAATGC 16 V_FREAC3_01_M00291 TRANSFAC - 95768985 95769000 8.0E-06 GACGTGTAAACACTCA 16 V_ZFP105_03_M02827 TRANSFAC - 95763765 95763779 8.0E-06 AAGAAACAACAACAT 15 V_OCT1_03_M00137 TRANSFAC - 95767004 95767016 2.0E-06 CACATAATGAGAT 13 V_BEL1_B_M00312 TRANSFAC - 95767173 95767200 2.0E-06 GACTAGCTTAGAGATAAATGATTGCAAC 28 V_BEL1_B_M00312 TRANSFAC - 95767650 95767677 3.0E-06 AGACTGCTTATAGCTGAGCGATTCCGAG 28 V_GFI1_01_M00250 TRANSFAC - 95767334 95767357 4.0E-06 GAAAGGAAAATCAATGCAGATTGG 24 V_HNF4_01_B_M00411 TRANSFAC - 95767023 95767037 1.0E-05 GAAGTCAAAGGTTGC 15 V_NFAT_Q6_M00302 TRANSFAC - 95770122 95770133 1.0E-05 AAAAGGAAAACA 12 V_NGFIC_01_M00244 TRANSFAC - 95767543 95767554 9.0E-06 AAGCGTGGGAGG 12 V_POLY_C_M00212 TRANSFAC + 95766793 95766810 3.0E-06 AATTAAATCCCCAGTGTC 18 V_E2F1_01_M01250 TRANSFAC + 95767228 95767235 1.0E-05 CGTTTCTT 8 V_OLF1_01_M00261 TRANSFAC + 95767417 95767438 2.0E-06 GCGAATTCCCCAGAGGGTTCGG 22 V_OLF1_01_M00261 TRANSFAC + 95767910 95767931 9.0E-06 CGGAGCTCCCTAGAGAGTCGCG 22 V_FOXK1_04_M02856 TRANSFAC - 95763763 95763777 1.0E-06 GAAACAACAACATCC 15 V_EVI1_01_M00078 TRANSFAC - 95767186 95767201 3.0E-06 AGACTAGCTTAGAGAT 16 V_PAX2_01_M00098 TRANSFAC - 95766819 95766837 4.0E-06 ACAAATCATGTATGACCTA 19 V_REST_01_M01256 TRANSFAC + 95763726 95763747 0.0E+00 TACGGTCACTGTCCGTGGTCCT 22 V_OCT1_04_M00138 TRANSFAC - 95763771 95763793 6.0E-06 GTGTTCGAATGTAAAAGAAACAA 23 V_EBF1_01_M02267 TRANSFAC - 95767637 95767646 6.0E-06 ACCCTAGGGA 10 V_E2F_Q4_02_M00939 TRANSFAC - 95767517 95767525 6.0E-06 TTTGGCGCG 9 V_STAF_02_M00264 TRANSFAC + 95767542 95767562 9.0E-06 TCCTCCCACGCTTCAATGCAG 21 V_OCT4_02_M01124 TRANSFAC - 95767361 95767375 1.0E-06 ATTGTCTTTGAAATG 15 V_BLIMP1_Q6_M01066 TRANSFAC - 95770140 95770155 7.0E-06 AAAAGAGGGAAATGCA 16 V_HNF4A_02_M02868 TRANSFAC - 95767878 95767893 0.0E+00 TTATAAAGTCCAAGCT 16 V_NEUROD_02_M01288 TRANSFAC - 95768337 95768348 9.0E-06 CTGCAGCTGGGT 12 V_NEUROD_02_M01288 TRANSFAC + 95770100 95770111 9.0E-06 CTGCAGCTGGCC 12 V_ELF1_Q6_M00746 TRANSFAC + 95770163 95770174 1.0E-06 AAAATAGGAAAT 12 V_HOXB7_01_M01396 TRANSFAC + 95768382 95768397 9.0E-06 ACAGTAAATAATGCAA 16 V_POU6F1_02_M01462 TRANSFAC - 95767001 95767017 3.0E-06 GCACATAATGAGATCGG 17 V_CEBPA_01_M00116 TRANSFAC + 95767152 95767165 9.0E-06 TGATTACACAAATT 14 V_HNF1_01_M00132 TRANSFAC - 95767174 95767188 9.0E-06 GATAAATGATTGCAA 15 V_FOXL1_04_M02753 TRANSFAC + 95768380 95768396 4.0E-06 AAACAGTAAATAATGCA 17 V_E2F6_01_M01252 TRANSFAC + 95767228 95767235 1.0E-05 CGTTTCTT 8 V_GFI1B_01_M01058 TRANSFAC - 95767340 95767351 7.0E-06 AAAATCAATGCA 12 V_HDX_01_M01333 TRANSFAC + 95767171 95767187 3.0E-06 CAGTTGCAATCATTTAT 17 V_ATF2_Q5_M01862 TRANSFAC - 95769021 95769032 1.0E-05 ATCTGACGTCAA 12 V_RHOX11_05_M03099 TRANSFAC - 95763744 95763760 5.0E-06 ACAATGCTGTATTAGGA 17 V_ZBTB4_04_M02929 TRANSFAC - 95767892 95767907 1.0E-05 TTTTCACTGGGAACTT 16 V_NRSF_01_M00256 TRANSFAC - 95763730 95763750 1.0E-06 ATTAGGACCACGGACAGTGAC 21 V_NRSF_01_M00256 TRANSFAC + 95770015 95770035 3.0E-06 TTCAGCACCGAGGTCTGGACA 21 V_OTX2_01_M01387 TRANSFAC + 95768263 95768279 9.0E-06 TGGAGGGATTTTTCTTC 17 V_FOX_Q2_M00809 TRANSFAC - 95768382 95768394 9.0E-06 CATTATTTACTGT 13 V_REST_02_M02256 TRANSFAC - 95763730 95763750 0.0E+00 ATTAGGACCACGGACAGTGAC 21 V_REST_02_M02256 TRANSFAC + 95770015 95770035 1.0E-05 TTCAGCACCGAGGTCTGGACA 21 V_E2F_Q3_01_M00918 TRANSFAC - 95767517 95767525 6.0E-06 TTTGGCGCG 9 V_HSF_Q6_M00641 TRANSFAC - 95767397 95767409 8.0E-06 TGCTAGAGGCTTC 13 V_E2F_01_M00024 TRANSFAC + 95767764 95767778 0.0E+00 TTCCCGGGAAAACGA 15 V_POU6F1_03_M01479 TRANSFAC - 95767001 95767017 8.0E-06 GCACATAATGAGATCGG 17 V_FOXJ2_01_M00422 TRANSFAC + 95768379 95768396 1.0E-06 TAAACAGTAAATAATGCA 18 V_FOXO1_04_M01969 TRANSFAC - 95763759 95763778 1.0E-06 AGAAACAACAACATCCTGAC 20 V_HNF3B_Q6_M02014 TRANSFAC - 95768384 95768392 6.0E-06 TTATTTACT 9 V_IRF1_01_M00062 TRANSFAC + 95767294 95767306 3.0E-06 CAAAAGCAAAAGA 13 V_BARHL2_01_M01446 TRANSFAC + 95766786 95766801 9.0E-06 AATACACAATTAAATC 16 V_CP2_01_M00072 TRANSFAC + 95768332 95768342 6.0E-06 GCCCTACCCAG 11 V_MAFK_04_M02880 TRANSFAC + 95768385 95768399 8.0E-06 GTAAATAATGCAAGC 15 V_RHOX11_06_M03100 TRANSFAC - 95763744 95763760 6.0E-06 ACAATGCTGTATTAGGA 17 V_DEC_Q1_M00997 TRANSFAC - 95767732 95767744 0.0E+00 GTCCAAGTGAAGG 13 V_SOX14_03_M02798 TRANSFAC + 95767159 95767174 5.0E-06 ACAAATTACAATCAGT 16 V_SOX14_03_M02798 TRANSFAC - 95767159 95767174 7.0E-06 ACTGATTGTAATTTGT 16 V_NF1_Q6_M00193 TRANSFAC - 95770241 95770258 6.0E-06 TTTTGGCCTGAGTCCAAC 18 V_PPARG_01_M00512 TRANSFAC - 95767020 95767040 3.0E-06 ACAGAAGTCAAAGGTTGCCAG 21

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.