Search TFs or Genes

Construction and Validation

Optimal Promoter Size

Download

Citation and Contact

MDH2 Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 4191 malate dehydrogenase 2, NAD (mitochondrial) chr7 + 75672392 - 75677892 75677392 Transcription Factor Binding Sites   Download all TFBS in the MDH2 promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints HOXD12_homeodomain_DBD_monomeric_9_1 SELEX + 75678253 75678261 2.0E-06 CTAATAAAA 9 Hoxc10_homeodomain_DBD_monomeric_10_2 SELEX + 75678253 75678262 3.0E-06 CTAATAAAAA 10 GABPA_MA0062.2 JASPAR + 75677311 75677321 0.0E+00 CCGGAAGTGGC 11 Myc_MA0147.1 JASPAR - 75677592 75677601 4.0E-06 CGCACGTGGC 10 SPIC_ETS_full_monomeric_14_1 SELEX - 75677873 75677886 9.0E-06 AAAAAACGTAAGTT 14 SPIC_ETS_full_monomeric_14_1 SELEX - 75677967 75677980 4.0E-06 GGAATTAGGAAGTA 14 FLI1_ETS_full_monomeric_10_1 SELEX + 75677354 75677363 7.0E-06 ACCGGAAGTC 10 ETV5_ETS_DBD_monomeric_10_1 SELEX + 75677354 75677363 7.0E-06 ACCGGAAGTC 10 ERG_ETS_full_monomeric_10_1 SELEX + 75677354 75677363 5.0E-06 ACCGGAAGTC 10 ETV3_ETS_DBD_monomeric_10_1 SELEX + 75677354 75677363 3.0E-06 ACCGGAAGTC 10 MEF2D_MADS_DBD_dimeric_12_1 SELEX - 75678186 75678197 0.0E+00 GCTAAAAATAGC 12 En1_MA0027.1 JASPAR + 75676770 75676780 5.0E-06 AAGTTGTTGTC 11 ELF4_ETS_full_monomeric_12_1 SELEX + 75677308 75677319 5.0E-06 CTCCCGGAAGTG 12 IRF8_IRF_full_dimeric_14_1 SELEX - 75673345 75673358 8.0E-06 TTGCAAGTGAAACT 14 YY1_C2H2_full_monomeric_11_1 SELEX + 75676845 75676855 8.0E-06 GTCGCCATTAT 11 FEV_ETS_DBD_monomeric_10_1 SELEX + 75677354 75677363 6.0E-06 ACCGGAAGTC 10 ETV1_ETS_DBD_monomeric_10_1 SELEX + 75677354 75677363 7.0E-06 ACCGGAAGTC 10 ERG_ETS_full_dimeric_14_1 SELEX + 75677354 75677367 0.0E+00 ACCGGAAGTCCGGT 14 ERG_ETS_full_dimeric_14_1 SELEX - 75677354 75677367 9.0E-06 ACCGGACTTCCGGT 14 MEF2A_MADS_DBD_dimeric_12_1 SELEX - 75678186 75678197 0.0E+00 GCTAAAAATAGC 12 NKX3-2_homeodomain_DBD_monomeric_9_1 SELEX + 75678163 75678171 2.0E-06 ACCACTTAA 9 FOXD2_forkhead_DBD_dimeric_14_1 SELEX + 75676283 75676296 9.0E-06 TAAAAATATGTATC 14 RUNX3_RUNX_full_monomeric_10_1 SELEX - 75681286 75681295 3.0E-06 AAACCACAAT 10 MEF2B_MADS_full_dimeric_12_1 SELEX - 75678186 75678197 0.0E+00 GCTAAAAATAGC 12 HOXD11_homeodomain_DBD_monomeric_10_2 SELEX + 75678252 75678261 5.0E-06 GCTAATAAAA 10 RUNX2_RUNX_DBD_monomeric_9_1 SELEX - 75681287 75681295 8.0E-06 AAACCACAA 9 NKX3-1_homeodomain_full_monomeric_9_1 SELEX + 75678163 75678171 2.0E-06 ACCACTTAA 9 HOXC12_homeodomain_DBD_monomeric_9_1 SELEX + 75678253 75678261 7.0E-06 CTAATAAAA 9 ELF3_ETS_full_monomeric_13_1 SELEX + 75677308 75677320 1.0E-05 CTCCCGGAAGTGG 13 MEF2A_MA0052.1 JASPAR + 75678187 75678196 1.0E-06 CTATTTTTAG 10 HOXD13_homeodomain_DBD_monomeric_10_1 SELEX + 75678253 75678262 1.0E-06 CTAATAAAAA 10 FOXJ3_forkhead_DBD_dimeric_14_1 SELEX + 75678252 75678265 1.0E-05 GCTAATAAAAAACA 14 HOXC11_homeodomain_full_monomeric_11_2 SELEX + 75678252 75678262 7.0E-06 GCTAATAAAAA 11 ETS1_ETS_full_monomeric_10_1 SELEX + 75677354 75677363 9.0E-06 ACCGGAAGTC 10 POU2F3_POU_DBD_dimeric_12_1 SELEX + 75676284 75676295 4.0E-06 AAAAATATGTAT 12 ELK4_ETS_DBD_monomeric_10_1 SELEX + 75677354 75677363 5.0E-06 ACCGGAAGTC 10 ELK4_MA0076.1 JASPAR + 75677354 75677362 4.0E-06 ACCGGAAGT 9 Lhx3_MA0135.1 JASPAR - 75676270 75676282 8.0E-06 AAATTAAACAACA 13 HOXA13_homeodomain_full_monomeric_10_1 SELEX + 75678253 75678262 1.0E-06 CTAATAAAAA 10 Mycn_MA0104.2 JASPAR - 75677592 75677601 5.0E-06 CGCACGTGGC 10 NKX2-3_homeodomain_full_monomeric_10_1 SELEX + 75678163 75678172 2.0E-06 ACCACTTAAG 10 INSM1_MA0155.1 JASPAR + 75676260 75676271 9.0E-06 TGCCTGGGGGTG 12 ERF_ETS_DBD_monomeric_10_1 SELEX + 75677354 75677363 5.0E-06 ACCGGAAGTC 10 ELK1_ETS_full_monomeric_10_1 SELEX + 75677354 75677363 4.0E-06 ACCGGAAGTC 10 POU5F1P1_POU_DBD_monomeric_12_1 SELEX + 75676284 75676295 6.0E-06 AAAAATATGTAT 12 Pou5f1_MA0142.1 JASPAR - 75677856 75677870 2.0E-06 CTTTCAGATGCAGAG 15 Tp53_p53l_DBD_dimeric_17_1 SELEX - 75677813 75677829 7.0E-06 GCAAGCCAAGAGCAGGT 17 HOXC13_homeodomain_DBD_monomeric_10_1 SELEX + 75678253 75678262 1.0E-06 CTAATAAAAA 10 ELF3_ETS_DBD_monomeric_12_1 SELEX + 75677308 75677319 8.0E-06 CTCCCGGAAGTG 12 Elk3_ETS_DBD_monomeric_10_1 SELEX + 75677354 75677363 4.0E-06 ACCGGAAGTC 10 RUNX1_MA0002.2 JASPAR + 75681285 75681295 5.0E-06 GATTGTGGTTT 11 POU3F3_POU_DBD_dimeric_12_1 SELEX + 75676284 75676295 7.0E-06 AAAAATATGTAT 12 Hoxa11_homeodomain_DBD_monomeric_11_1 SELEX + 75678252 75678262 2.0E-06 GCTAATAAAAA 11 Hic1_C2H2_DBD_dimeric_18_1 SELEX + 75677449 75677466 8.0E-06 CTGCCAGTCGGTGCCCCT 18 FLI1_ETS_full_monomeric_14_1 SELEX + 75677354 75677367 0.0E+00 ACCGGAAGTCCGGT 14 FLI1_ETS_full_monomeric_14_1 SELEX - 75677354 75677367 6.0E-06 ACCGGACTTCCGGT 14 CDX2_homeodomain_DBD_monomeric_9_1 SELEX + 75678253 75678261 9.0E-06 CTAATAAAA 9 HOXA10_homeodomain_DBD_monomeric_11_1 SELEX + 75678252 75678262 5.0E-06 GCTAATAAAAA 11 ONECUT3_CUT_DBD_monomeric_14_1 SELEX + 75673367 75673380 9.0E-06 GTAAAATCAATGCC 14 HOXB13_homeodomain_DBD_monomeric_10_1 SELEX + 75678253 75678262 1.0E-06 CTAATAAAAA 10 IRF2_MA0051.1 JASPAR - 75673340 75673357 4.0E-06 TGCAAGTGAAACTTATAT 18 FOXJ2_forkhead_DBD_dimeric_14_1 SELEX + 75678252 75678265 8.0E-06 GCTAATAAAAAACA 14 V_ERG_03_M02062 TRANSFAC + 75677354 75677363 5.0E-06 ACCGGAAGTC 10 V_ERM_01_M01992 TRANSFAC + 75677354 75677363 7.0E-06 ACCGGAAGTC 10 V_SAP1A_01_M01167 TRANSFAC + 75677353 75677363 4.0E-06 GACCGGAAGTC 11 V_TEL1_02_M02070 TRANSFAC + 75677310 75677319 5.0E-06 CCCGGAAGTG 10 V_STAT3_01_M00225 TRANSFAC + 75677302 75677322 1.0E-05 TTCCGACTCCCGGAAGTGGCC 21 V_ELK1_04_M01165 TRANSFAC + 75677353 75677363 3.0E-06 GACCGGAAGTC 11 V_MYOD_Q6_M00184 TRANSFAC - 75678828 75678837 7.0E-06 TCCACCTGTC 10 V_MAX_Q6_M01830 TRANSFAC + 75677589 75677600 6.0E-06 CGGGCCACGTGC 12 V_AML3_Q6_M01856 TRANSFAC - 75681287 75681294 1.0E-05 AACCACAA 8 V_NERF_01_M01976 TRANSFAC + 75677310 75677319 9.0E-06 CCCGGAAGTG 10 V_MMEF2_Q6_M00405 TRANSFAC - 75676274 75676289 1.0E-06 ATTTTTAAAATTAAAC 16 V_MMEF2_Q6_M00405 TRANSFAC - 75678185 75678200 2.0E-06 ATGGCTAAAAATAGCC 16 V_POU5F1_02_M02245 TRANSFAC - 75677856 75677870 2.0E-06 CTTTCAGATGCAGAG 15 V_CBF_02_M01080 TRANSFAC + 75681283 75681298 3.0E-06 AGGATTGTGGTTTTGT 16 V_MAFB_03_M02879 TRANSFAC + 75676277 75676291 3.0E-06 TAATTTTAAAAATAT 15 V_MAFB_03_M02879 TRANSFAC + 75681292 75681306 7.0E-06 GTTTTGTAAAAATTA 15 V_MEF2_02_M00231 TRANSFAC - 75678182 75678203 0.0E+00 AAGATGGCTAAAAATAGCCTAG 22 V_ZTA_Q2_M00711 TRANSFAC - 75678232 75678244 8.0E-06 TGATTCTGACACA 13 V_IRF2_Q6_M01882 TRANSFAC - 75673343 75673358 7.0E-06 TTGCAAGTGAAACTTA 16 V_PRX2_Q2_M02115 TRANSFAC - 75676276 75676284 5.0E-06 TAAAATTAA 9 V_HOXD13_01_M01404 TRANSFAC + 75678250 75678265 1.0E-06 AAGCTAATAAAAAACA 16 V_SOX21_03_M02803 TRANSFAC + 75676275 75676290 8.0E-06 TTTAATTTTAAAAATA 16 V_SOX21_03_M02803 TRANSFAC - 75676275 75676290 8.0E-06 TATTTTTAAAATTAAA 16 V_CDX_Q5_M00991 TRANSFAC + 75677951 75677968 9.0E-06 AATAAAAGAAATCGTATA 18 V_LDSPOLYA_B_M00317 TRANSFAC - 75678254 75678269 8.0E-06 CGTCTGTTTTTTATTA 16 V_HBP1_Q2_M01661 TRANSFAC - 75678276 75678284 3.0E-06 TTCAATGAA 9 V_MEF2A_Q6_M02024 TRANSFAC - 75676281 75676290 1.0E-06 TATTTTTAAA 10 V_MEF2A_Q6_M02024 TRANSFAC + 75678188 75678197 1.0E-06 TATTTTTAGC 10 V_PEA3_01_M01991 TRANSFAC + 75677354 75677363 8.0E-06 ACCGGAAGTC 10 V_ELF2_02_M02054 TRANSFAC + 75677310 75677319 8.0E-06 CCCGGAAGTG 10 V_MYC_01_M02250 TRANSFAC - 75677592 75677601 4.0E-06 CGCACGTGGC 10 V_HNF6_Q6_M00639 TRANSFAC + 75673368 75673379 4.0E-06 TAAAATCAATGC 12 V_ELF4_04_M02850 TRANSFAC - 75676271 75676287 8.0E-06 TTTTAAAATTAAACAAC 17 V_ELF4_04_M02850 TRANSFAC + 75678252 75678268 5.0E-06 GCTAATAAAAAACAGAC 17 V_ELK1_06_M02059 TRANSFAC + 75677354 75677363 4.0E-06 ACCGGAAGTC 10 V_CRX_Q4_M00623 TRANSFAC + 75677970 75677982 1.0E-05 TTCCTAATTCCAT 13 V_POU3F2_01_M00463 TRANSFAC - 75676282 75676295 7.0E-06 ATACATATTTTTAA 14 V_FKLF_Q5_M01837 TRANSFAC - 75676939 75676948 2.0E-06 GGGGTGGGAG 10 V_BEL1_B_M00312 TRANSFAC - 75677415 75677442 4.0E-06 GAGCTGGTGACGGGGAAGTGACTCCAAC 28 V_HOXB13_01_M01467 TRANSFAC + 75678250 75678265 0.0E+00 AAGCTAATAAAAAACA 16 V_SAP1A_02_M01983 TRANSFAC + 75677354 75677363 7.0E-06 ACCGGAAGTC 10 V_RUNX1_01_M02257 TRANSFAC + 75681285 75681295 5.0E-06 GATTGTGGTTT 11 V_GFI1_01_M00250 TRANSFAC + 75673363 75673386 0.0E+00 CCAAGTAAAATCAATGCCTACCAC 24 V_NKX31_02_M02782 TRANSFAC + 75681271 75681287 2.0E-06 TTATACTACTTAAGGAT 17 V_XFD3_01_M00269 TRANSFAC + 75681294 75681307 1.0E-05 TTTGTAAAAATTAA 14 V_AML2_01_M01759 TRANSFAC - 75681287 75681294 1.0E-05 AACCACAA 8 V_RSRFC4_Q2_M00407 TRANSFAC - 75678183 75678199 0.0E+00 TGGCTAAAAATAGCCTA 17 V_AMEF2_Q6_M00403 TRANSFAC - 75676272 75676289 7.0E-06 ATTTTTAAAATTAAACAA 18 V_AMEF2_Q6_M00403 TRANSFAC - 75678183 75678200 0.0E+00 ATGGCTAAAAATAGCCTA 18 V_HOXB9_01_M01426 TRANSFAC + 75678250 75678265 2.0E-06 AAGCTAATAAAAAACA 16 V_RXRA_04_M02895 TRANSFAC - 75676781 75676796 7.0E-06 GCAAATAGGTTGTAGG 16 V_HNF3_Q6_M00791 TRANSFAC - 75676788 75676800 9.0E-06 ATGAGCAAATAGG 13 V_HNF3ALPHA_Q6_M00724 TRANSFAC + 75676790 75676800 7.0E-06 TATTTGCTCAT 11 V_ERG_01_M01752 TRANSFAC + 75677354 75677362 4.0E-06 ACCGGAAGT 9 V_HNF1_Q6_01_M01011 TRANSFAC - 75676270 75676290 4.0E-06 TATTTTTAAAATTAAACAACA 21 V_CETS2_01_M01989 TRANSFAC + 75677354 75677363 7.0E-06 ACCGGAAGTC 10 V_MEF2_03_M00232 TRANSFAC + 75676275 75676296 8.0E-06 TTTAATTTTAAAAATATGTATC 22 V_MEF2_03_M00232 TRANSFAC - 75678182 75678203 0.0E+00 AAGATGGCTAAAAATAGCCTAG 22 V_NFE4_Q5_M02105 TRANSFAC + 75677624 75677635 6.0E-06 GACCCTCTCCAG 12 V_CDX1_01_M01373 TRANSFAC + 75678249 75678264 9.0E-06 AAAGCTAATAAAAAAC 16 V_OCT1_04_M00138 TRANSFAC - 75676273 75676295 5.0E-06 ATACATATTTTTAAAATTAAACA 23 V_PITX3_01_M01343 TRANSFAC - 75677910 75677925 8.0E-06 AAGGAGATTAGCTACG 16 V_OCT1_08_M01354 TRANSFAC + 75681295 75681310 2.0E-06 TTGTAAAAATTAAGTT 16 V_MEF2_04_M00233 TRANSFAC - 75678182 75678203 1.0E-06 AAGATGGCTAAAAATAGCCTAG 22 V_PAX8_01_M00717 TRANSFAC + 75677939 75677953 4.0E-06 GAGTTGTGCGTGAAT 15 V_PNR_01_M01650 TRANSFAC + 75678038 75678051 1.0E-05 AGGATTAGAATTCA 14 V_MEF2_Q6_01_M00941 TRANSFAC + 75678185 75678196 0.0E+00 GGCTATTTTTAG 12 V_CETS1P54_01_M00032 TRANSFAC + 75677354 75677363 5.0E-06 ACCGGAAGTC 10 V_MYCN_01_M02259 TRANSFAC - 75677592 75677601 5.0E-06 CGCACGTGGC 10 V_TEL1_01_M01993 TRANSFAC + 75677310 75677319 5.0E-06 CCCGGAAGTG 10 V_TBP_06_M02814 TRANSFAC + 75676275 75676290 1.0E-06 TTTAATTTTAAAAATA 16 V_TBP_06_M02814 TRANSFAC + 75676277 75676292 8.0E-06 TAATTTTAAAAATATG 16 V_TBP_06_M02814 TRANSFAC - 75676277 75676292 4.0E-06 CATATTTTTAAAATTA 16 V_PEA3_02_M02066 TRANSFAC + 75677354 75677363 8.0E-06 ACCGGAAGTC 10 V_OCT4_02_M01124 TRANSFAC + 75673347 75673361 1.0E-06 TTTCACTTGCAAAAC 15 V_INSM1_01_M02268 TRANSFAC + 75676260 75676271 9.0E-06 TGCCTGGGGGTG 12 V_ELF4_01_M01979 TRANSFAC + 75677310 75677319 4.0E-06 CCCGGAAGTG 10 V_PAX8_B_M00328 TRANSFAC + 75677938 75677955 2.0E-06 TGAGTTGTGCGTGAATAA 18 V_ERM_02_M02069 TRANSFAC + 75677354 75677363 8.0E-06 ACCGGAAGTC 10 V_MTF1_06_M02882 TRANSFAC + 75676277 75676290 3.0E-06 TAATTTTAAAAATA 14 V_MTF1_06_M02882 TRANSFAC + 75678251 75678264 3.0E-06 AGCTAATAAAAAAC 14 V_MTF1_06_M02882 TRANSFAC + 75678254 75678267 7.0E-06 TAATAAAAAACAGA 14 V_CEBPA_01_M00116 TRANSFAC - 75681290 75681303 9.0E-06 TTTTTACAAAACCA 14 V_FOXL1_02_M02857 TRANSFAC - 75676268 75676283 1.0E-06 AAAATTAAACAACACC 16 V_MYCMAX_B_M00322 TRANSFAC + 75677592 75677601 7.0E-06 GCCACGTGCG 10 V_NRF2_01_M00108 TRANSFAC + 75677354 75677363 5.0E-06 ACCGGAAGTC 10 V_RSRFC4_01_M00026 TRANSFAC + 75676273 75676288 9.0E-06 TGTTTAATTTTAAAAA 16 V_RSRFC4_01_M00026 TRANSFAC + 75678184 75678199 0.0E+00 AGGCTATTTTTAGCCA 16 V_RSRFC4_01_M00026 TRANSFAC - 75678184 75678199 6.0E-06 TGGCTAAAAATAGCCT 16 V_PLZF_02_M01075 TRANSFAC - 75673335 75673363 8.0E-06 GTGTTTTGCAAGTGAAACTTATATTAAAC 29 V_T3RBETA_Q6_01_M02119 TRANSFAC + 75678816 75678832 8.0E-06 GAGTAAACTTAGGACAG 17 V_IRF1_Q6_01_M01881 TRANSFAC + 75673344 75673357 8.0E-06 AAGTTTCACTTGCA 14 V_CETS1_02_M02063 TRANSFAC + 75677354 75677363 8.0E-06 ACCGGAAGTC 10 V_SRF_06_M02916 TRANSFAC - 75677877 75677893 7.0E-06 CTGCAGAAAAAAACGTA 17 V_SRF_06_M02916 TRANSFAC + 75678252 75678268 3.0E-06 GCTAATAAAAAACAGAC 17 V_COREBINDINGFACTOR_Q6_M00722 TRANSFAC + 75681288 75681295 1.0E-05 TGTGGTTT 8 V_NET_02_M02060 TRANSFAC + 75677354 75677363 8.0E-06 ACCGGAAGTC 10 V_ELF_02_M02053 TRANSFAC + 75677310 75677319 1.0E-05 CCCGGAAGTG 10 V_MEF2_01_M00006 TRANSFAC - 75678183 75678198 4.0E-06 GGCTAAAAATAGCCTA 16 V_MEF2A_05_M01301 TRANSFAC + 75678185 75678196 0.0E+00 GGCTATTTTTAG 12 V_HMEF2_Q6_M00406 TRANSFAC - 75676272 75676287 3.0E-06 TTTTAAAATTAAACAA 16 V_HMEF2_Q6_M00406 TRANSFAC - 75678183 75678198 1.0E-06 GGCTAAAAATAGCCTA 16 V_HOXA10_01_M01464 TRANSFAC + 75678250 75678265 1.0E-06 AAGCTAATAAAAAACA 16 V_HOXD10_01_M01375 TRANSFAC + 75678250 75678266 2.0E-06 AAGCTAATAAAAAACAG 17 V_TCF3_05_M02920 TRANSFAC + 75678250 75678264 1.0E-06 AAGCTAATAAAAAAC 15 V_GLIS2_04_M02863 TRANSFAC + 75676275 75676288 6.0E-06 TTTAATTTTAAAAA 14 V_GLIS2_04_M02863 TRANSFAC - 75676279 75676292 7.0E-06 CATATTTTTAAAAT 14 V_PAX4_04_M00380 TRANSFAC - 75676266 75676295 3.0E-06 ATACATATTTTTAAAATTAAACAACACCCC 30 V_PAX4_04_M00380 TRANSFAC + 75677951 75677980 9.0E-06 AATAAAAGAAATCGTATACTTCCTAATTCC 30 V_ETV3_02_M02068 TRANSFAC + 75677354 75677363 9.0E-06 ACCGGAAGTC 10 V_AP2_Q3_M00800 TRANSFAC - 75677110 75677125 1.0E-06 GGCCCCAGGCAGAGGC 16 V_T3RALPHA_Q6_M01724 TRANSFAC - 75678058 75678068 3.0E-06 CTTCAGGTCAG 11

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.