Search TFs or Genes

Construction and Validation

Optimal Promoter Size

Download

Citation and Contact

KL Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 9365 klotho chr13 + 33585570 - 33591070 33590570 Transcription Factor Binding Sites   Download all TFBS in the KL promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints SOX4_HMG_DBD_dimeric_16_1 SELEX + 33591812 33591827 7.0E-06 TCACGAGTTCAGTGTT 16 ALX3_homeodomain_full_monomeric_10_1 SELEX - 33588714 33588723 8.0E-06 TTCAATTAGA 10 BARX1_homeodomain_DBD_dimeric_17_1 SELEX - 33588716 33588732 5.0E-06 TTGTTAAGTTTCAATTA 17 POU3F3_POU_DBD_monomeric_12_1 SELEX + 33593376 33593387 6.0E-06 TTGAATTAATTT 12 Arx_homeodomain_DBD_dimeric_13_1 SELEX + 33591826 33591838 5.0E-06 TTAATCCAATAAG 13 Arx_homeodomain_DBD_dimeric_13_1 SELEX - 33591826 33591838 7.0E-06 CTTATTGGATTAA 13 POU3F2_POU_DBD_monomeric_13_1 SELEX + 33593375 33593387 8.0E-06 CTTGAATTAATTT 13 POU3F4_POU_DBD_monomeric_11_1 SELEX + 33593377 33593387 1.0E-05 TGAATTAATTT 11 ESRRG_nuclearreceptor_full_dimeric_17_1 SELEX - 33589266 33589282 2.0E-06 AAGGTGACTCAAAGACA 17 Alx1_homeodomain_DBD_dimeric_13_1 SELEX + 33591826 33591838 6.0E-06 TTAATCCAATAAG 13 Barhl1_homeodomain_DBD_monomeric_10_1 SELEX - 33588546 33588555 7.0E-06 ACTAAACGTT 10 OTX2_homeodomain_DBD_dimeric_15_1 SELEX + 33591825 33591839 1.0E-05 GTTAATCCAATAAGA 15 PROP1_homeodomain_full_dimeric_11_1 SELEX + 33591827 33591837 5.0E-06 TAATCCAATAA 11 ALX3_homeodomain_full_dimeric_13_1 SELEX + 33591826 33591838 4.0E-06 TTAATCCAATAAG 13 DRGX_homeodomain_DBD_dimeric_13_1 SELEX + 33591826 33591838 3.0E-06 TTAATCCAATAAG 13 PHOX2B_homeodomain_full_dimeric_11_1 SELEX + 33591827 33591837 5.0E-06 TAATCCAATAA 11 Alx4_homeodomain_DBD_dimeric_13_1 SELEX + 33591826 33591838 6.0E-06 TTAATCCAATAAG 13 Lhx3_MA0135.1 JASPAR - 33593375 33593387 4.0E-06 AAATTAATTCAAG 13 ZNF143_C2H2_DBD_monomeric_16_1 SELEX + 33588699 33588714 8.0E-06 GACCCATGAAGCATTT 16 Msx3_homeodomain_DBD_dimeric_18_1 SELEX - 33588716 33588733 1.0E-05 CTTGTTAAGTTTCAATTA 18 VENTX_homeodomain_DBD_dimeric_21_1 SELEX - 33588681 33588701 2.0E-06 GTCTCATGGAAAATCGCTTAA 21 PRRX1_homeodomain_full_dimeric_11_1 SELEX + 33591827 33591837 3.0E-06 TAATCCAATAA 11 TBX2_TBX_full_monomeric_11_1 SELEX + 33591876 33591886 7.0E-06 AAAGTGTCAAA 11 CART1_homeodomain_DBD_dimeric_13_1 SELEX + 33591826 33591838 2.0E-06 TTAATCCAATAAG 13 HESX1_homeodomain_DBD_dimeric_15_1 SELEX + 33588715 33588729 3.0E-06 CTAATTGAAACTTAA 15 Uncx_homeodomain_DBD_dimeric_13_1 SELEX + 33591826 33591838 4.0E-06 TTAATCCAATAAG 13 Pou5f1_MA0142.1 JASPAR + 33588501 33588515 7.0E-06 CTTTGAGATGCATGT 15 PHOX2A_homeodomain_DBD_dimeric_11_1 SELEX + 33591827 33591837 4.0E-06 TAATCCAATAA 11 TP53_MA0106.1 JASPAR + 33588475 33588494 0.0E+00 GGGAACATGTCTTGGAATGC 20 MSX1_homeodomain_DBD_dimeric_18_1 SELEX - 33588716 33588733 8.0E-06 CTTGTTAAGTTTCAATTA 18 Sox2_MA0143.1 JASPAR + 33589538 33589552 2.0E-06 CCATTGTATTGTAGA 15 V_NFAT_Q4_01_M00935 TRANSFAC - 33588687 33588696 5.0E-06 ATGGAAAATC 10 V_MEIS1BHOXA9_02_M00421 TRANSFAC - 33591871 33591884 1.0E-06 TGACACTTTCACAA 14 V_TGIF_01_M00418 TRANSFAC + 33591807 33591817 3.0E-06 AGCTGTCACGA 11 V_TST1_02_M01316 TRANSFAC - 33593374 33593390 3.0E-06 ACAAAATTAATTCAAGA 17 V_TST1_02_M01316 TRANSFAC + 33593375 33593391 7.0E-06 CTTGAATTAATTTTGTT 17 V_NRSF_Q4_M01028 TRANSFAC + 33590624 33590642 0.0E+00 TCGCTGTCGCTGCTGCTGG 19 V_NRSF_Q4_M01028 TRANSFAC + 33590630 33590648 2.0E-06 TCGCTGCTGCTGGTGCTGC 19 V_NRSF_Q4_M01028 TRANSFAC + 33590633 33590651 2.0E-06 CTGCTGCTGGTGCTGCTGG 19 V_HNF1_02_M01379 TRANSFAC - 33588548 33588564 1.0E-06 ACCAAGTTAACTAAACG 17 V_HNF1_02_M01379 TRANSFAC - 33589435 33589451 9.0E-06 TTGTGGCTAACCGAAAT 17 V_ZFX_01_M01593 TRANSFAC + 33590729 33590744 7.0E-06 CCCGAGGCCGCGGGCC 16 V_ACAAT_B_M00309 TRANSFAC - 33591958 33591966 8.0E-06 GATTGGTGG 9 V_HMGIY_Q3_M01010 TRANSFAC + 33593379 33593393 6.0E-06 AATTAATTTTGTTGT 15 V_BCL6_01_M01183 TRANSFAC + 33593372 33593387 0.0E+00 TATCTTGAATTAATTT 16 V_GATA3_03_M00351 TRANSFAC - 33591835 33591844 4.0E-06 ACAGATCTTA 10 V_POU5F1_02_M02245 TRANSFAC + 33588501 33588515 7.0E-06 CTTTGAGATGCATGT 15 V_SATB1_Q3_M01723 TRANSFAC - 33593369 33593384 9.0E-06 TTAATTCAAGATACTT 16 V_HEN1_01_M00068 TRANSFAC + 33590115 33590136 9.0E-06 AGTGAGAGCAGGTGCTTCCCCA 22 V_HEN1_01_M00068 TRANSFAC - 33590115 33590136 9.0E-06 TGGGGAAGCACCTGCTCTCACT 22 V_LHX3A_01_M00510 TRANSFAC - 33593377 33593386 7.0E-06 AATTAATTCA 10 V_LHX3A_01_M00510 TRANSFAC + 33593379 33593388 4.0E-06 AATTAATTTT 10 V_NFAT2_01_M01748 TRANSFAC - 33588688 33588696 2.0E-06 ATGGAAAAT 9 V_PAX7_01_M01339 TRANSFAC - 33588710 33588726 7.0E-06 AGTTTCAATTAGAAATG 17 V_HMBOX1_01_M01456 TRANSFAC + 33588546 33588562 5.0E-06 AACGTTTAGTTAACTTG 17 V_HELIOSA_02_M01004 TRANSFAC - 33588688 33588698 9.0E-06 TCATGGAAAAT 11 V_DBX2_01_M01360 TRANSFAC + 33593376 33593391 2.0E-06 TTGAATTAATTTTGTT 16 V_NFAT_Q6_M00302 TRANSFAC + 33589517 33589528 7.0E-06 AACAGGAAAAAC 12 V_P53_03_M01651 TRANSFAC - 33588477 33588496 3.0E-06 AAGCATTCCAAGACATGTTC 20 V_FOXK1_04_M02856 TRANSFAC - 33593382 33593396 9.0E-06 CATACAACAAAATTA 15 V_MAZ_Q6_01_M02023 TRANSFAC + 33591702 33591715 8.0E-06 GAGGGCGGGGAGGA 14 V_HNF1_Q6_01_M01011 TRANSFAC + 33593480 33593500 9.0E-06 ACCTGAAAAAGATAAAACATT 21 V_OCT1_08_M01354 TRANSFAC + 33593376 33593391 3.0E-06 TTGAATTAATTTTGTT 16 V_HBP1_03_M02762 TRANSFAC + 33593373 33593388 5.0E-06 ATCTTGAATTAATTTT 16 V_PIT1_01_M01465 TRANSFAC - 33593374 33593390 5.0E-06 ACAAAATTAATTCAAGA 17 V_PIT1_01_M01465 TRANSFAC + 33593375 33593391 3.0E-06 CTTGAATTAATTTTGTT 17 V_IRF4_03_M02768 TRANSFAC + 33588715 33588729 7.0E-06 CTAATTGAAACTTAA 15 V_RREB1_01_M00257 TRANSFAC + 33589385 33589398 4.0E-06 CCCCAAATCACAAA 14 V_ISGF3G_03_M02771 TRANSFAC + 33588714 33588728 3.0E-06 TCTAATTGAAACTTA 15 V_POU6F1_01_M00465 TRANSFAC - 33593380 33593390 7.0E-06 ACAAAATTAAT 11 V_LHX3b_01_M01971 TRANSFAC + 33593379 33593388 1.0E-06 AATTAATTTT 10 V_LIM1_01_M01418 TRANSFAC - 33588710 33588726 2.0E-06 AGTTTCAATTAGAAATG 17 V_GFI1_Q6_M01067 TRANSFAC + 33588572 33588584 6.0E-06 TTTAATCACTGCT 13 V_RARA_04_M02891 TRANSFAC + 33591000 33591015 7.0E-06 AGCTCGGGGTCACTCA 16 V_AP4_01_M00005 TRANSFAC + 33591165 33591182 9.0E-06 TGCCCCAGCGCCTGCAGG 18 V_BRN4_01_M01473 TRANSFAC - 33593374 33593390 4.0E-06 ACAAAATTAATTCAAGA 17 V_BRN4_01_M01473 TRANSFAC + 33593375 33593391 3.0E-06 CTTGAATTAATTTTGTT 17 V_HEN1_02_M00058 TRANSFAC + 33590115 33590136 1.0E-06 AGTGAGAGCAGGTGCTTCCCCA 22 V_HEN1_02_M00058 TRANSFAC - 33590115 33590136 4.0E-06 TGGGGAAGCACCTGCTCTCACT 22 V_GFI1B_01_M01058 TRANSFAC + 33588573 33588584 6.0E-06 TTAATCACTGCT 12 V_TCF1_06_M02815 TRANSFAC - 33588548 33588564 0.0E+00 ACCAAGTTAACTAAACG 17 V_TCF1_06_M02815 TRANSFAC + 33588549 33588565 5.0E-06 GTTTAGTTAACTTGGTC 17 V_DMRT7_01_M01151 TRANSFAC + 33593376 33593389 6.0E-06 TTGAATTAATTTTG 14 V_HNF1B_01_M01425 TRANSFAC - 33588547 33588563 4.0E-06 CCAAGTTAACTAAACGT 17 V_HNF1B_01_M01425 TRANSFAC + 33588550 33588566 2.0E-06 TTTAGTTAACTTGGTCT 17 V_NRSF_01_M00256 TRANSFAC - 33590623 33590643 7.0E-06 ACCAGCAGCAGCGACAGCGAC 21 V_TBX15_02_M01264 TRANSFAC + 33591869 33591886 1.0E-06 TGTTGTGAAAGTGTCAAA 18 V_P53_05_M01655 TRANSFAC + 33588477 33588496 1.0E-06 GAACATGTCTTGGAATGCTT 20 V_P53_05_M01655 TRANSFAC - 33588477 33588496 1.0E-06 AAGCATTCCAAGACATGTTC 20 V_P53_01_M00034 TRANSFAC + 33588477 33588496 3.0E-06 GAACATGTCTTGGAATGCTT 20 V_P53_01_M00034 TRANSFAC - 33588477 33588496 5.0E-06 AAGCATTCCAAGACATGTTC 20 V_BBX_03_M02739 TRANSFAC - 33593373 33593387 8.0E-06 AAATTAATTCAAGAT 15 V_HSF_Q6_M00641 TRANSFAC + 33589369 33589381 1.0E-06 TTACAGAGGTTTC 13 V_P63_01_M01656 TRANSFAC + 33588477 33588496 8.0E-06 GAACATGTCTTGGAATGCTT 20 V_P63_01_M01656 TRANSFAC - 33588477 33588496 7.0E-06 AAGCATTCCAAGACATGTTC 20 V_SOX2_01_M02246 TRANSFAC + 33589538 33589552 2.0E-06 CCATTGTATTGTAGA 15 V_SOX1_03_M02802 TRANSFAC - 33593371 33593386 7.0E-06 AATTAATTCAAGATAC 16 V_HOXD10_01_M01375 TRANSFAC - 33593380 33593396 1.0E-06 CATACAACAAAATTAAT 17 V_RNF96_01_M01199 TRANSFAC - 33590734 33590743 7.0E-06 GCCCGCGGCC 10 V_PBX1_04_M01357 TRANSFAC - 33593381 33593397 3.0E-06 TCATACAACAAAATTAA 17 V_NR2F2_04_M02887 TRANSFAC + 33591000 33591015 2.0E-06 AGCTCGGGGTCACTCA 16 V_NANOG_02_M01247 TRANSFAC - 33589533 33589552 6.0E-06 TCTACAATACAATGGAGCCA 20 V_OCT4_01_M01125 TRANSFAC + 33589539 33589553 9.0E-06 CATTGTATTGTAGAG 15

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.