Search TFs or Genes

Construction and Validation

Optimal Promoter Size

Download

Citation and Contact

MANF Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 7873 mesencephalic astrocyte-derived neurotrophic factor chr3 + 51417691 - 51423191 51422691 Transcription Factor Binding Sites   Download all TFBS in the MANF promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints NKX2-8_homeodomain_full_monomeric_9_1 SELEX + 51421785 51421793 8.0E-06 GCACTTGAA 9 CTCF_MA0139.1 JASPAR - 51426159 51426177 7.0E-06 CCCCCACAAGAGGGAACTA 19 CTCF_MA0139.1 JASPAR + 51426954 51426972 0.0E+00 GTACCACTAGAGGGCAGCA 19 MYBL2_MYB_DBD_dimeric_16_1 SELEX + 51422180 51422195 7.0E-06 AAGGTTGGATCCGTTG 16 NR4A2_nuclearreceptor_full_monomeric_11_1 SELEX + 51423402 51423412 8.0E-06 TTTATAGGTCA 11 NFYA_MA0060.1 JASPAR + 51422558 51422573 2.0E-06 ACCAGCCAATGAGGGA 16 Tcfap2a_TFAP_DBD_dimeric_13_1 SELEX + 51421759 51421771 7.0E-06 TGCCTTGAAGGCA 13 TFAP2C_TFAP_full_dimeric_13_1 SELEX + 51421759 51421771 5.0E-06 TGCCTTGAAGGCA 13 TFAP2C_TFAP_full_dimeric_13_1 SELEX - 51421759 51421771 8.0E-06 TGCCTTCAAGGCA 13 RORA_nuclearreceptor_DBD_dimeric_19_1 SELEX + 51423402 51423420 1.0E-06 TTTATAGGTCATTGGGTGA 19 ESRRG_nuclearreceptor_full_dimeric_18_1 SELEX + 51423395 51423412 6.0E-06 GAAGTCGTTTATAGGTCA 18 GRHL1_CP2_DBD_dimer-of-dimers_17_1 SELEX - 51426230 51426246 7.0E-06 AACCAGCCCTACTGGTT 17 SP1_MA0079.2 JASPAR - 51422968 51422977 7.0E-06 CCCCGCCCCC 10 SP1_MA0079.2 JASPAR - 51422974 51422983 7.0E-06 CCCCGCCCCC 10 SP1_MA0079.2 JASPAR - 51426997 51427006 7.0E-06 CCCCGCCCCC 10 CTCF_C2H2_full_monomeric_17_1 SELEX - 51426955 51426971 3.0E-06 GCTGCCCTCTAGTGGTA 17 YY2_C2H2_full_monomeric_11_1 SELEX - 51422459 51422469 4.0E-06 GCCGCCATCTT 11 TFAP2B_TFAP_DBD_dimeric_13_1 SELEX + 51421759 51421771 4.0E-06 TGCCTTGAAGGCA 13 TFAP2B_TFAP_DBD_dimeric_13_1 SELEX - 51421759 51421771 5.0E-06 TGCCTTCAAGGCA 13 TP53_MA0106.1 JASPAR + 51426186 51426205 2.0E-06 ACTGACATGCCTGTAAATGT 20 IRF3_IRF_full_trimeric_21_1 SELEX + 51422207 51422227 7.0E-06 GAAAGAAGAAAAAAGAAACCT 21 RREB1_MA0073.1 JASPAR + 51422925 51422944 8.0E-06 CCCCACAACATCACCAGACG 20 V_SPI1_01_M01203 TRANSFAC + 51422615 51422631 4.0E-06 CCAATGGGGAAGTGGCA 17 V_RORA1_01_M00156 TRANSFAC + 51423401 51423413 2.0E-06 GTTTATAGGTCAT 13 V_BCL6_01_M01183 TRANSFAC - 51424880 51424895 4.0E-06 TTTGAGATAAAGTTTT 16 V_EBOX_Q6_01_M01034 TRANSFAC - 51422148 51422157 4.0E-06 CCACCTGACC 10 V_RORA_Q4_M01138 TRANSFAC + 51423402 51423412 9.0E-06 TTTATAGGTCA 11 V_IRF_Q6_01_M00972 TRANSFAC + 51422215 51422225 5.0E-06 AAAAAAGAAAC 11 V_YY1_Q6_M00793 TRANSFAC - 51422458 51422466 7.0E-06 GCCATCTTG 9 V_P53_DECAMER_Q2_M00761 TRANSFAC + 51421713 51421722 2.0E-06 AGACATGTCC 10 V_IRF3_05_M02767 TRANSFAC + 51422214 51422227 6.0E-06 GAAAAAAGAAACCT 14 V_SP1_03_M02281 TRANSFAC - 51422968 51422977 7.0E-06 CCCCGCCCCC 10 V_SP1_03_M02281 TRANSFAC - 51422974 51422983 7.0E-06 CCCCGCCCCC 10 V_SP1_03_M02281 TRANSFAC - 51426997 51427006 7.0E-06 CCCCGCCCCC 10 V_SP1_02_M01303 TRANSFAC + 51422969 51422979 8.0E-06 GGGGCGGGGGC 11 V_SP1_02_M01303 TRANSFAC + 51422975 51422985 8.0E-06 GGGGCGGGGGC 11 V_SP1_02_M01303 TRANSFAC + 51426998 51427008 3.0E-06 GGGGCGGGGGG 11 V_PU1_Q4_M01172 TRANSFAC - 51422207 51422225 4.0E-06 GTTTCTTTTTTCTTCTTTC 19 V_TCFAP2E_04_M02926 TRANSFAC + 51424888 51424901 0.0E+00 ATCTCAAAAAAAAA 14 V_TCFAP2E_04_M02926 TRANSFAC + 51424890 51424903 2.0E-06 CTCAAAAAAAAAAA 14 V_HBP1_Q2_M01661 TRANSFAC + 51422519 51422527 8.0E-06 TTCAATCAG 9 V_P53_02_M00272 TRANSFAC + 51421713 51421722 5.0E-06 AGACATGTCC 10 V_P53_02_M00272 TRANSFAC - 51421713 51421722 7.0E-06 GGACATGTCT 10 V_P53_02_M00272 TRANSFAC + 51426188 51426197 7.0E-06 TGACATGCCT 10 V_TAL1_GATA1_01_M02243 TRANSFAC - 51424885 51424902 7.0E-06 TTTTTTTTTTGAGATAAA 18 V_WT1_Q6_01_M02036 TRANSFAC - 51422977 51422986 4.0E-06 CGCCCCCGCC 10 V_WT1_Q6_01_M02036 TRANSFAC - 51426994 51427003 4.0E-06 CGCCCCCGCC 10 V_ETS_Q4_M00771 TRANSFAC + 51422494 51422505 4.0E-06 AGTCGCTTCCTG 12 V_CP2_02_M00947 TRANSFAC - 51422418 51422432 7.0E-06 GCTGGGTACTGCTAG 15 V_ELF4_04_M02850 TRANSFAC + 51424888 51424904 5.0E-06 ATCTCAAAAAAAAAAAA 17 V_ELF4_04_M02850 TRANSFAC + 51424889 51424905 0.0E+00 TCTCAAAAAAAAAAAAA 17 V_ELF4_04_M02850 TRANSFAC + 51424890 51424906 3.0E-06 CTCAAAAAAAAAAAAAA 17 V_ZNF219_01_M01122 TRANSFAC - 51426999 51427010 5.0E-06 CACCCCCCGCCC 12 V_ZFP105_03_M02827 TRANSFAC + 51424890 51424904 1.0E-06 CTCAAAAAAAAAAAA 15 V_KROX_Q6_M00982 TRANSFAC - 51426992 51427005 0.0E+00 CCCGCCCCCGCCAC 14 V_SP1_Q6_M00196 TRANSFAC + 51422967 51422979 9.0E-06 CGGGGGCGGGGGC 13 V_SP1_Q6_M00196 TRANSFAC + 51422973 51422985 9.0E-06 CGGGGGCGGGGGC 13 V_EGR1_Q6_M01873 TRANSFAC + 51422966 51422975 4.0E-06 GCGGGGGCGG 10 V_EGR1_Q6_M01873 TRANSFAC + 51422972 51422981 4.0E-06 GCGGGGGCGG 10 V_EGR1_Q6_M01873 TRANSFAC + 51426995 51427004 4.0E-06 GCGGGGGCGG 10 V_NKX22_02_M01372 TRANSFAC + 51421781 51421797 9.0E-06 GAGGGCACTTGAAAGGA 17 V_ISRE_01_M00258 TRANSFAC - 51422213 51422227 3.0E-06 AGGTTTCTTTTTTCT 15 V_YY1_Q6_02_M01035 TRANSFAC - 51422459 51422469 7.0E-06 GCCGCCATCTT 11 V_REX1_03_M01744 TRANSFAC + 51422459 51422470 0.0E+00 AAGATGGCGGCC 12 Tal1_Gata1_MA0140.1 JASPAR - 51424885 51424902 7.0E-06 TTTTTTTTTTGAGATAAA 18 V_ERR1_Q3_M01841 TRANSFAC - 51423401 51423415 3.0E-06 CAATGACCTATAAAC 15 V_SPIB_01_M01204 TRANSFAC + 51422615 51422631 8.0E-06 CCAATGGGGAAGTGGCA 17 V_SP1_01_M00008 TRANSFAC - 51427022 51427031 7.0E-06 GGGGCAGGGT 10 V_CTCF_02_M01259 TRANSFAC - 51426161 51426180 4.0E-06 CTGCCCCCACAAGAGGGAAC 20 V_CTCF_02_M01259 TRANSFAC + 51426951 51426970 0.0E+00 TGTGTACCACTAGAGGGCAG 20 V_CTCF_01_M01200 TRANSFAC - 51426159 51426178 5.0E-06 GCCCCCACAAGAGGGAACTA 20 V_CTCF_01_M01200 TRANSFAC + 51426953 51426972 0.0E+00 TGTACCACTAGAGGGCAGCA 20 V_GATA4_Q3_M00632 TRANSFAC + 51422213 51422224 4.0E-06 AGAAAAAAGAAA 12 V_SP4_Q5_M01273 TRANSFAC - 51422968 51422978 5.0E-06 CCCCCGCCCCC 11 V_SP4_Q5_M01273 TRANSFAC - 51422974 51422984 5.0E-06 CCCCCGCCCCC 11 V_SP4_Q5_M01273 TRANSFAC - 51426997 51427007 5.0E-06 CCCCCGCCCCC 11 V_YY1_03_M02044 TRANSFAC - 51422458 51422469 1.0E-06 GCCGCCATCTTG 12 V_CAAT_01_M00254 TRANSFAC + 51422558 51422569 4.0E-06 ACCAGCCAATGA 12 V_ALPHACP1_01_M00687 TRANSFAC + 51422560 51422570 0.0E+00 CAGCCAATGAG 11 V_MTF1_06_M02882 TRANSFAC + 51422208 51422221 0.0E+00 AAAGAAGAAAAAAG 14 V_HAND1E47_01_M00222 TRANSFAC + 51426200 51426215 0.0E+00 AAATGTGTCTGGAAAT 16 V_SP4_04_M02914 TRANSFAC + 51422392 51422406 2.0E-06 GTAAGGCGTGGCCGA 15 V_E2F3_03_M02743 TRANSFAC - 51422063 51422077 8.0E-06 CTCAAGGCGCGCCAA 15 V_SMAD3_03_M02794 TRANSFAC - 51426200 51426216 7.0E-06 CATTTCCAGACACATTT 17 V_NFY_01_M00287 TRANSFAC + 51422558 51422573 1.0E-06 ACCAGCCAATGAGGGA 16 V_E2F2_03_M02742 TRANSFAC - 51422063 51422077 2.0E-06 CTCAAGGCGCGCCAA 15 V_FPM315_01_M01587 TRANSFAC + 51422742 51422753 3.0E-06 GGAGGAGGAGGA 12 V_FPM315_01_M01587 TRANSFAC + 51422745 51422756 3.0E-06 GGAGGAGGAGGA 12 V_FPM315_01_M01587 TRANSFAC + 51422748 51422759 3.0E-06 GGAGGAGGAGGA 12 V_FPM315_01_M01587 TRANSFAC + 51422751 51422762 3.0E-06 GGAGGAGGAGGA 12 V_FPM315_01_M01587 TRANSFAC + 51422754 51422765 3.0E-06 GGAGGAGGAGGA 12 V_FPM315_01_M01587 TRANSFAC + 51422757 51422768 3.0E-06 GGAGGAGGAGGA 12 V_FPM315_01_M01587 TRANSFAC + 51422760 51422771 3.0E-06 GGAGGAGGAGGA 12 V_FPM315_01_M01587 TRANSFAC + 51422763 51422774 3.0E-06 GGAGGAGGAGGA 12 V_VDR_Q6_M00961 TRANSFAC - 51422516 51422527 9.0E-06 CTGATTGAACCC 12 V_TCF4_Q5_M00671 TRANSFAC - 51422176 51422183 1.0E-05 CCTTTGAA 8 V_PLZF_02_M01075 TRANSFAC - 51424872 51424900 2.0E-06 TTTTTTTTGAGATAAAGTTTTGCTCTGTC 29 V_ETS1_B_M00339 TRANSFAC - 51422492 51422506 7.0E-06 GCAGGAAGCGACTAC 15 V_EGR1_06_M02744 TRANSFAC - 51422963 51422976 8.0E-06 CCCGCCCCCGCCCT 14 V_IRF1_Q6_01_M01881 TRANSFAC - 51422214 51422227 8.0E-06 AGGTTTCTTTTTTC 14 V_SRF_06_M02916 TRANSFAC + 51422207 51422223 5.0E-06 GAAAGAAGAAAAAAGAA 17 V_SRF_06_M02916 TRANSFAC + 51424888 51424904 6.0E-06 ATCTCAAAAAAAAAAAA 17 V_SRF_06_M02916 TRANSFAC + 51424889 51424905 0.0E+00 TCTCAAAAAAAAAAAAA 17 V_SRF_06_M02916 TRANSFAC + 51424890 51424906 0.0E+00 CTCAAAAAAAAAAAAAA 17 V_SP1_Q2_01_M00933 TRANSFAC - 51422968 51422977 4.0E-06 CCCCGCCCCC 10 V_SP1_Q2_01_M00933 TRANSFAC - 51422974 51422983 4.0E-06 CCCCGCCCCC 10 V_SP1_Q2_01_M00933 TRANSFAC - 51426997 51427006 4.0E-06 CCCCGCCCCC 10 V_NFYA_Q5_M02106 TRANSFAC + 51422560 51422573 1.0E-06 CAGCCAATGAGGGA 14 V_TCF11MAFG_01_M00284 TRANSFAC + 51424865 51424886 4.0E-06 CCTGGGTGACAGAGCAAAACTT 22 V_TCF3_05_M02920 TRANSFAC + 51424889 51424903 4.0E-06 TCTCAAAAAAAAAAA 15 V_SMAD1_01_M01590 TRANSFAC + 51422209 51422220 7.0E-06 AAGAAGAAAAAA 12 V_NANOG_02_M01247 TRANSFAC + 51422205 51422224 2.0E-06 ATGAAAGAAGAAAAAAGAAA 20

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.