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PCSK4 Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 54760 proprotein convertase subtilisin/kexin type 4 chr19 - 1489907 - 1495407 1490407 Transcription Factor Binding Sites   Download all TFBS in the PCSK4 promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints POU4F2_POU_full_monomeric_16_1 SELEX + 1493599 1493614 3.0E-06 TTGAATAATTCAGGAA 16 Rxrb_nuclearreceptor_DBD_dimeric_14_1 SELEX - 1492901 1492914 3.0E-06 GAGGGCAGAGGTCA 14 ESRRA_nuclearreceptor_DBD_dimeric_19_1 SELEX - 1490638 1490656 2.0E-06 AGAGGTCAAACAAAGGGTA 19 POU3F4_POU_DBD_monomeric_11_1 SELEX - 1493645 1493655 9.0E-06 TGCATTTATTA 11 RXRG_nuclearreceptor_full_dimeric_14_1 SELEX - 1492901 1492914 4.0E-06 GAGGGCAGAGGTCA 14 RXRG_nuclearreceptor_full_dimeric_14_1 SELEX + 1493148 1493161 4.0E-06 GATGTCCAAGGTCA 14 NR2F6_nuclearreceptor_full_dimeric_14_1 SELEX - 1492901 1492914 1.0E-06 GAGGGCAGAGGTCA 14 NR2F6_nuclearreceptor_full_dimeric_14_1 SELEX + 1493148 1493161 5.0E-06 GATGTCCAAGGTCA 14 ESRRG_nuclearreceptor_full_dimeric_17_1 SELEX - 1493391 1493407 8.0E-06 AAAAGCACCCAAGGTCA 17 ESRRG_nuclearreceptor_full_dimeric_17_1 SELEX - 1493560 1493576 1.0E-05 GGTGTTGCCCAAGGTCA 17 Esrrb_MA0141.1 JASPAR + 1493150 1493161 3.0E-06 TGTCCAAGGTCA 12 Esrrb_MA0141.1 JASPAR - 1493391 1493402 6.0E-06 CACCCAAGGTCA 12 Esrrb_MA0141.1 JASPAR - 1493560 1493571 2.0E-06 TGCCCAAGGTCA 12 STAT1_MA0137.2 JASPAR + 1492615 1492629 2.0E-06 CTCTTCCAGGAAGCT 15 NR2F1_MA0017.1 JASPAR + 1492901 1492914 4.0E-06 TGACCTCTGCCCTC 14 POU4F3_POU_DBD_monomeric_16_1 SELEX + 1493599 1493614 2.0E-06 TTGAATAATTCAGGAA 16 RARG_nuclearreceptor_full_dimeric_18_1 SELEX - 1490638 1490655 0.0E+00 GAGGTCAAACAAAGGGTA 18 Egr1_C2H2_mouse-DBD_mutant_DBD_monomeric_16_1 SELEX + 1490888 1490903 1.0E-05 TTCCGCCCCCCCACGC 16 Egr1_C2H2_mouse-DBD_mutant_DBD_monomeric_16_1 SELEX + 1493570 1493585 7.0E-06 CAACACCCACCCACCC 16 Rfx3_RFX_DBD_dimeric_16_1 SELEX - 1490429 1490444 8.0E-06 CGTTGCTATGGCGCCG 16 ESRRG_nuclearreceptor_full_dimeric_18_1 SELEX - 1490638 1490655 2.0E-06 GAGGTCAAACAAAGGGTA 18 Esrra_nuclearreceptor_DBD_dimeric_17_1 SELEX - 1493560 1493576 6.0E-06 GGTGTTGCCCAAGGTCA 17 RUNX2_RUNX_DBD_dimeric_18_1 SELEX + 1489705 1489722 1.0E-06 CAACCACGAGAACCACAG 18 E2F8_E2F_DBD_dimeric_12_1 SELEX + 1490384 1490395 4.0E-06 CCTCCCGCCAAA 12 Rarb_nuclearreceptor_DBD_dimeric_17_1 SELEX - 1490638 1490654 1.0E-06 AGGTCAAACAAAGGGTA 17 SP1_MA0079.2 JASPAR + 1490875 1490884 3.0E-06 CCCCTCCCCC 10 SP1_MA0079.2 JASPAR + 1491091 1491100 9.0E-06 CCCCTCCTCC 10 NR2F1_nuclearreceptor_DBD_dimeric_15_1 SELEX - 1492900 1492914 2.0E-06 GAGGGCAGAGGTCAG 15 NR2F1_nuclearreceptor_DBD_dimeric_15_1 SELEX + 1493148 1493162 6.0E-06 GATGTCCAAGGTCAT 15 RARA_nuclearreceptor_full_dimeric_17_1 SELEX - 1490638 1490654 2.0E-06 AGGTCAAACAAAGGGTA 17 znf143_MA0088.1 JASPAR + 1490455 1490474 1.0E-05 CGACTCCCAGGGGGCCTTGC 20 ESRRG_nuclearreceptor_full_monomeric_10_1 SELEX + 1493153 1493162 4.0E-06 CCAAGGTCAT 10 NR2C2_nuclearreceptor_DBD_dimeric_14_1 SELEX - 1492901 1492914 2.0E-06 GAGGGCAGAGGTCA 14 ZNF143_C2H2_DBD_monomeric_16_1 SELEX - 1492664 1492679 3.0E-06 TACCCAGAATACCCCA 16 POU1F1_POU_DBD_monomeric_17_1 SELEX + 1493596 1493612 1.0E-06 CTGTTGAATAATTCAGG 17 RFX5_RFX_DBD_dimeric_16_3 SELEX + 1490429 1490444 4.0E-06 CGGCGCCATAGCAACG 16 Stat3_MA0144.1 JASPAR - 1492617 1492626 2.0E-06 TTCCTGGAAG 10 Stat3_MA0144.1 JASPAR + 1492618 1492627 1.0E-06 TTCCAGGAAG 10 Esrra_nuclearreceptor_DBD_monomeric_11_1 SELEX + 1493152 1493162 1.0E-06 TCCAAGGTCAT 11 JDP2_bZIP_full_dimeric_9_1 SELEX + 1492637 1492645 7.0E-06 ATGACTCAC 9 TFAP4_bHLH_full_dimeric_10_1 SELEX + 1489690 1489699 9.0E-06 CACAGCTGTT 10 HNF4A_MA0114.1 JASPAR - 1492901 1492913 3.0E-06 AGGGCAGAGGTCA 13 HNF4A_MA0114.1 JASPAR - 1493455 1493467 5.0E-06 GGACCAAAGGGCA 13 ESRRB_nuclearreceptor_DBD_monomeric_11_1 SELEX + 1493153 1493163 3.0E-06 CCAAGGTCATC 11 ESRRB_nuclearreceptor_DBD_monomeric_11_1 SELEX - 1493558 1493568 6.0E-06 CCAAGGTCACA 11 HLF_MA0043.1 JASPAR - 1490726 1490737 8.0E-06 GATTACGCAAAA 12 RORA_nuclearreceptor_DBD_dimeric_20_1 SELEX - 1490638 1490657 5.0E-06 GAGAGGTCAAACAAAGGGTA 20 HNF4A_nuclearreceptor_full_dimeric_14_1 SELEX - 1492901 1492914 6.0E-06 GAGGGCAGAGGTCA 14 Zfp740_C2H2_DBD_monomeric_10_1 SELEX + 1490892 1490901 1.0E-05 GCCCCCCCAC 10 RXRA_nuclearreceptor_full_dimeric_14_1 SELEX - 1492901 1492914 3.0E-06 GAGGGCAGAGGTCA 14 MSC_bHLH_full_dimeric_10_1 SELEX - 1489690 1489699 9.0E-06 AACAGCTGTG 10 POU4F1_POU_DBD_monomeric_14_1 SELEX + 1493599 1493612 3.0E-06 TTGAATAATTCAGG 14 RUNX3_RUNX_DBD_dimeric_18_1 SELEX + 1489705 1489722 0.0E+00 CAACCACGAGAACCACAG 18 RXR_RAR_DR5_MA0159.1 JASPAR - 1490638 1490654 5.0E-06 AGGTCAAACAAAGGGTA 17 V_OBOX6_01_M01445 TRANSFAC - 1490933 1490947 4.0E-06 AGGATGGGATTATTG 15 V_AP2ALPHA_Q6_M01857 TRANSFAC - 1491137 1491147 6.0E-06 CGCCCCCGGCC 11 V_CDX2_Q5_01_M01659 TRANSFAC + 1493644 1493654 1.0E-05 TTAATAAATGC 11 V_APOLYA_B_M00310 TRANSFAC - 1493634 1493648 1.0E-06 ATTAAGCGCCTATTG 15 V_FLI1_Q6_M01208 TRANSFAC - 1491294 1491304 7.0E-06 CAGGAAGTGCT 11 V_ZFP410_04_M02936 TRANSFAC - 1493193 1493209 2.0E-06 GCGTCCCTCCCCTAAAT 17 V_YY1_02_M00069 TRANSFAC - 1489716 1489735 3.0E-06 CACCAGCCATCTTCTGTGGT 20 V_LRH1_Q5_01_M02098 TRANSFAC + 1493151 1493161 1.0E-06 GTCCAAGGTCA 11 V_LRH1_Q5_01_M02098 TRANSFAC - 1493560 1493570 9.0E-06 GCCCAAGGTCA 11 V_AP4_Q6_M00176 TRANSFAC + 1489690 1489699 8.0E-06 CACAGCTGTT 10 V_RFX4_03_M02789 TRANSFAC + 1490432 1490446 1.0E-06 CGCCATAGCAACGCA 15 V_EAR2_Q2_M01728 TRANSFAC + 1492901 1492914 3.0E-06 TGACCTCTGCCCTC 14 V_GABPA_04_M02858 TRANSFAC - 1493508 1493523 5.0E-06 CCTTCTTCCTCCTCCC 16 V_SP1_03_M02281 TRANSFAC + 1490875 1490884 3.0E-06 CCCCTCCCCC 10 V_SP1_03_M02281 TRANSFAC + 1491091 1491100 9.0E-06 CCCCTCCTCC 10 V_HNF4A_03_M02220 TRANSFAC - 1492901 1492913 3.0E-06 AGGGCAGAGGTCA 13 V_HNF4A_03_M02220 TRANSFAC - 1493455 1493467 5.0E-06 GGACCAAAGGGCA 13 V_PITX2_Q6_M02114 TRANSFAC + 1490934 1490943 6.0E-06 AATAATCCCA 10 V_NERF_Q2_M00531 TRANSFAC - 1491290 1491307 3.0E-06 CTCCAGGAAGTGCTCCAC 18 V_PPAR_DR1_Q2_M00763 TRANSFAC + 1492901 1492913 2.0E-06 TGACCTCTGCCCT 13 V_E2A_Q2_M00804 TRANSFAC - 1493416 1493429 3.0E-06 CCACCTGCTTTAGT 14 V_HEN1_01_M00068 TRANSFAC - 1489739 1489760 6.0E-06 CGGGGTCTCAGCTGCCTCCTGG 22 V_AP4_Q6_02_M01860 TRANSFAC + 1490232 1490244 4.0E-06 CCAGCTGCTGACA 13 V_COUPTF_Q6_M01036 TRANSFAC + 1490644 1490666 3.0E-06 TTGTTTGACCTCTCCCACTTTCC 23 V_COUPTF_Q6_M01036 TRANSFAC + 1492896 1492918 3.0E-06 GTCCCTGACCTCTGCCCTCCCTT 23 V_PPARGRXRA_01_M02262 TRANSFAC - 1492901 1492915 0.0E+00 GGAGGGCAGAGGTCA 15 V_PPARGRXRA_01_M02262 TRANSFAC - 1493455 1493469 2.0E-06 CTGGACCAAAGGGCA 15 V_PITX1_Q6_M01826 TRANSFAC + 1490931 1490941 5.0E-06 GCCAATAATCC 11 V_BACH1_01_M00495 TRANSFAC - 1492634 1492648 4.0E-06 CTTGTGAGTCATTCT 15 V_GC_01_M00255 TRANSFAC - 1490803 1490816 8.0E-06 GGAGGGCGGGGCTG 14 V_GC_01_M00255 TRANSFAC - 1491088 1491101 8.0E-06 AGGAGGAGGGGCCT 14 V_CRX_Q4_M00623 TRANSFAC + 1490932 1490944 4.0E-06 CCAATAATCCCAT 13 V_POU3F2_01_M00463 TRANSFAC - 1493643 1493656 4.0E-06 CTGCATTTATTAAG 14 V_COUP_01_M00158 TRANSFAC + 1492901 1492914 4.0E-06 TGACCTCTGCCCTC 14 V_POLY_C_M00212 TRANSFAC + 1490933 1490950 5.0E-06 CAATAATCCCATCCTCTG 18 V_MRF2_01_M00454 TRANSFAC + 1490587 1490600 1.0E-05 AACGACAAGACTAA 14 V_OLF1_01_M00261 TRANSFAC + 1490453 1490474 5.0E-06 TTCGACTCCCAGGGGGCCTTGC 22 V_SP1_Q6_M00196 TRANSFAC - 1490804 1490816 7.0E-06 GGAGGGCGGGGCT 13 V_SP1_Q6_M00196 TRANSFAC - 1490873 1490885 5.0E-06 GGGGGGAGGGGCT 13 V_SP1_Q6_M00196 TRANSFAC - 1491014 1491026 6.0E-06 AGAGGGCGGGGCG 13 V_MAZ_Q6_01_M02023 TRANSFAC + 1489552 1489565 9.0E-06 AGAGGAGGGAGGGG 14 V_AP2BETA_Q3_M01858 TRANSFAC + 1491131 1491146 3.0E-06 GCGGGGGGCCGGGGGC 16 V_AP2BETA_Q3_M01858 TRANSFAC + 1493428 1493443 8.0E-06 GGGAGGGGCTGGGGGG 16 V_NKX52_01_M01315 TRANSFAC + 1493636 1493652 4.0E-06 ATAGGCGCTTAATAAAT 17 V_RFXDC2_03_M02790 TRANSFAC + 1490432 1490446 2.0E-06 CGCCATAGCAACGCA 15 V_SFPI1_04_M02896 TRANSFAC + 1493603 1493616 2.0E-06 ATAATTCAGGAAAA 14 V_JUNDM2_04_M02876 TRANSFAC + 1492633 1492648 2.0E-06 CAGAATGACTCACAAG 16 V_REX1_03_M01744 TRANSFAC + 1489723 1489734 5.0E-06 AAGATGGCTGGT 12 V_SP1SP3_Q4_M01219 TRANSFAC + 1490738 1490748 5.0E-06 CCGCCTCCTCC 11 V_AP4_Q5_M00175 TRANSFAC + 1489690 1489699 8.0E-06 CACAGCTGTT 10 V_PPARG_03_M00528 TRANSFAC - 1492901 1492917 8.0E-06 AGGGAGGGCAGAGGTCA 17 V_MUSCLE_INI_B_M00321 TRANSFAC + 1490141 1490161 8.0E-06 TCCCGGTCCCACCCACCGGCC 21 V_DAX1_01_M01248 TRANSFAC + 1493148 1493167 3.0E-06 GATGTCCAAGGTCATCCTCC 20 V_ERALPHA_01_M01801 TRANSFAC - 1491501 1491515 8.0E-06 AGGTCCCAGTCACCT 15 V_RREB1_01_M00257 TRANSFAC + 1493574 1493587 6.0E-06 ACCCACCCACCCCC 14 V_KLF7_03_M02773 TRANSFAC + 1490802 1490817 9.0E-06 TCAGCCCCGCCCTCCA 16 V_HNF4_DR1_Q3_M00764 TRANSFAC + 1492901 1492913 6.0E-06 TGACCTCTGCCCT 13 V_STAF_02_M00264 TRANSFAC + 1490456 1490476 8.0E-06 GACTCCCAGGGGGCCTTGCGG 21 V_SP3_Q3_M00665 TRANSFAC - 1493134 1493147 3.0E-06 AGAACTGTGGAGGG 14 V_STAT3_03_M01595 TRANSFAC - 1492613 1492628 1.0E-06 GCTTCCTGGAAGAGAA 16 V_NR1B1_Q6_M02110 TRANSFAC - 1490647 1490656 4.0E-06 AGAGGTCAAA 10 V_IRF7_01_M00453 TRANSFAC - 1490568 1490585 9.0E-06 TACAAATGGGAAAACTGA 18 V_SF1_Q6_01_M01132 TRANSFAC - 1493153 1493161 7.0E-06 TGACCTTGG 9 V_SF1_Q6_01_M01132 TRANSFAC + 1493391 1493399 7.0E-06 TGACCTTGG 9 V_SF1_Q6_01_M01132 TRANSFAC + 1493560 1493568 7.0E-06 TGACCTTGG 9 V_BCL6B_04_M02844 TRANSFAC + 1490764 1490779 8.0E-06 GTTCCCGCCCCTACCA 16 V_SP4_Q5_M01273 TRANSFAC + 1490874 1490884 5.0E-06 GCCCCTCCCCC 11 V_LRH1_Q5_M01142 TRANSFAC - 1493151 1493162 1.0E-06 ATGACCTTGGAC 12 V_AP1_Q4_01_M00926 TRANSFAC - 1492637 1492644 1.0E-05 TGAGTCAT 8 V_CAAT_01_M00254 TRANSFAC + 1490927 1490938 9.0E-06 TTCAGCCAATAA 12 V_RARA_04_M02891 TRANSFAC + 1489827 1489842 2.0E-06 AGTGCGGGGTCAGGGA 16 V_NFYC_Q5_M02107 TRANSFAC + 1490988 1491001 1.0E-05 CGGCCAATCGGTGC 14 V_TAL1_01_M01591 TRANSFAC + 1492608 1492620 4.0E-06 CTGCCTTCTCTTC 13 V_E2F_Q6_01_M00920 TRANSFAC + 1490385 1490396 4.0E-06 CTCCCGCCAAAC 12 V_SMAD4_04_M02898 TRANSFAC + 1490382 1490398 4.0E-06 TCCCTCCCGCCAAACCG 17 V_DR1_Q3_M00762 TRANSFAC - 1492901 1492913 3.0E-06 AGGGCAGAGGTCA 13 V_HEN1_02_M00058 TRANSFAC - 1489739 1489760 4.0E-06 CGGGGTCTCAGCTGCCTCCTGG 22 V_LUN1_01_M00480 TRANSFAC + 1490203 1490219 9.0E-06 TCCCGGTTACCCTGGGA 17 V_ZSCAN4_04_M02942 TRANSFAC + 1493613 1493628 8.0E-06 AAAAGCACAAAACCTG 16 V_ZSCAN4_04_M02942 TRANSFAC + 1493625 1493640 4.0E-06 CCTGGCACACAATAGG 16 NR1H2_RXRA_MA0115.1 JASPAR + 1493147 1493163 5.0E-06 TGATGTCCAAGGTCATC 17 V_HNF4_Q6_01_M01031 TRANSFAC - 1492900 1492913 4.0E-06 AGGGCAGAGGTCAG 14 V_ERR2_01_M01589 TRANSFAC + 1493153 1493164 3.0E-06 CCAAGGTCATCC 12 V_ERR2_01_M01589 TRANSFAC - 1493388 1493399 4.0E-06 CCAAGGTCAGGG 12 V_ERR2_01_M01589 TRANSFAC - 1493557 1493568 2.0E-06 CCAAGGTCACAC 12 V_FRA1_Q5_M01267 TRANSFAC - 1492637 1492644 1.0E-05 TGAGTCAT 8 V_FPM315_01_M01587 TRANSFAC + 1493506 1493517 2.0E-06 AGGGGAGGAGGA 12 V_ESRRA_03_M02748 TRANSFAC + 1493150 1493166 1.0E-06 TGTCCAAGGTCATCCTC 17 V_ZFP281_01_M01597 TRANSFAC - 1490875 1490885 2.0E-06 GGGGGGAGGGG 11 V_E2F_Q4_01_M00919 TRANSFAC + 1490386 1490396 4.0E-06 TCCCGCCAAAC 11 V_EGR1_06_M02744 TRANSFAC + 1490889 1490902 8.0E-06 TCCGCCCCCCCACG 14 V_HSF_Q6_M00641 TRANSFAC - 1493175 1493187 1.0E-05 TTCCTGCAGCTTC 13 V_RXR_RAR_01_M02272 TRANSFAC - 1490638 1490654 5.0E-06 AGGTCAAACAAAGGGTA 17 V_MYF6_03_M02781 TRANSFAC - 1489688 1489703 5.0E-06 TATGAACAGCTGTGTG 16 V_PUR1_Q4_M01721 TRANSFAC + 1493336 1493344 6.0E-06 GGGACAGTG 9 V_SOX4_01_M01308 TRANSFAC - 1490641 1490648 1.0E-05 AACAAAGG 8 V_EKLF_Q5_M01874 TRANSFAC + 1490551 1490560 5.0E-06 CCACACCCTC 10 V_RFX3_04_M02788 TRANSFAC + 1490428 1490450 9.0E-06 CCGGCGCCATAGCAACGCAGAAG 23 V_HNF4_01_M00134 TRANSFAC - 1493452 1493470 1.0E-05 TCTGGACCAAAGGGCAGAG 19 V_HMX3_02_M01413 TRANSFAC + 1493636 1493652 5.0E-06 ATAGGCGCTTAATAAAT 17 V_SP1_Q4_01_M00932 TRANSFAC - 1490804 1490816 6.0E-06 GGAGGGCGGGGCT 13 V_SP1_Q4_01_M00932 TRANSFAC - 1490873 1490885 6.0E-06 GGGGGGAGGGGCT 13 V_SP1_Q4_01_M00932 TRANSFAC - 1491014 1491026 3.0E-06 AGAGGGCGGGGCG 13 V_OBOX6_02_M03068 TRANSFAC - 1490933 1490947 4.0E-06 AGGATGGGATTATTG 15 V_COUP_DR1_Q6_M00765 TRANSFAC + 1492901 1492913 3.0E-06 TGACCTCTGCCCT 13 V_STAT1_05_M01260 TRANSFAC - 1492608 1492629 5.0E-06 AGCTTCCTGGAAGAGAAGGCAG 22 V_BHLHB2_04_M02845 TRANSFAC + 1492537 1492559 8.0E-06 TGGGATTACAGGTGGAAGCCACT 23 V_SOX9_Q4_M01284 TRANSFAC - 1490639 1490649 2.0E-06 AAACAAAGGGT 11 PPARG_RXRA_MA0065.2 JASPAR - 1492901 1492915 0.0E+00 GGAGGGCAGAGGTCA 15 PPARG_RXRA_MA0065.2 JASPAR - 1493455 1493469 2.0E-06 CTGGACCAAAGGGCA 15 V_PPARA_01_M00242 TRANSFAC - 1492901 1492920 8.0E-06 GAAAGGGAGGGCAGAGGTCA 20 V_TR4_03_M01782 TRANSFAC - 1492901 1492913 2.0E-06 AGGGCAGAGGTCA 13 V_AP2_Q3_M00800 TRANSFAC - 1490272 1490287 0.0E+00 GCCCCCGGGCTGTGGG 16 V_PPARG_01_M00512 TRANSFAC + 1493145 1493165 6.0E-06 TCTGATGTCCAAGGTCATCCT 21

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.