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PKLR Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 5313 pyruvate kinase, liver and RBC chr1 - 155270292 - 155276225 155270792 Transcription Factor Binding Sites   Download all TFBS in the PKLR promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints THRB_nuclearreceptor_DBD_dimeric_20_1 SELEX + 155275877 155275896 0.0E+00 TTGACCTGAAATCAGGCCAG 20 THRB_nuclearreceptor_DBD_dimeric_20_1 SELEX - 155275877 155275896 0.0E+00 CTGGCCTGATTTCAGGTCAA 20 HOXA10_homeodomain_DBD_monomeric_12_1 SELEX + 155274557 155274568 4.0E-06 AATCATTAAAAT 12 EBF1_EBF_full_dimeric_14_1 SELEX + 155275799 155275812 0.0E+00 AGTCCCAAGGGATT 14 EBF1_EBF_full_dimeric_14_1 SELEX - 155275799 155275812 0.0E+00 AATCCCTTGGGACT 14 HNF1B_MA0153.1 JASPAR - 155274554 155274565 0.0E+00 TTAATGATTAAC 12 Esrrb_MA0141.1 JASPAR + 155266677 155266688 1.0E-06 TTGTCAAGGTCA 12 E2F2_E2F_DBD_dimeric_16_1 SELEX - 155271452 155271467 3.0E-06 AAAATGGGGCCATATG 16 Klf4_MA0039.2 JASPAR + 155271519 155271528 1.0E-05 AGGGTGGGGC 10 Hoxc10_homeodomain_DBD_monomeric_10_1 SELEX + 155274558 155274567 6.0E-06 ATCATTAAAA 10 HNF1A_homeodomain_full_dimeric_15_1 SELEX + 155274553 155274567 0.0E+00 AGTTAATCATTAAAA 15 HNF1A_homeodomain_full_dimeric_15_1 SELEX - 155274553 155274567 0.0E+00 TTTTAATGATTAACT 15 HOXC11_homeodomain_DBD_monomeric_11_1 SELEX + 155274557 155274567 5.0E-06 AATCATTAAAA 11 ESRRG_nuclearreceptor_full_monomeric_10_1 SELEX + 155266680 155266689 3.0E-06 TCAAGGTCAC 10 MZF1_5-13_MA0057.1 JASPAR + 155274503 155274512 1.0E-06 GTAGGGGGAA 10 TEAD3_TEA_DBD_dimeric_17_1 SELEX - 155275703 155275719 5.0E-06 TCATGCCTGTAATTCCA 17 HNF1B_homeodomain_full_dimeric_13_1 SELEX + 155274554 155274566 0.0E+00 GTTAATCATTAAA 13 HNF1B_homeodomain_full_dimeric_13_1 SELEX - 155274554 155274566 0.0E+00 TTTAATGATTAAC 13 Hoxa11_homeodomain_DBD_monomeric_12_1 SELEX + 155274557 155274568 7.0E-06 AATCATTAAAAT 12 Esrra_nuclearreceptor_DBD_monomeric_11_1 SELEX + 155266679 155266689 3.0E-06 GTCAAGGTCAC 11 ERF_ETS_DBD_monomeric_10_1 SELEX - 155274603 155274612 9.0E-06 ACAGGAAGTG 10 Evi1_MA0029.1 JASPAR - 155271248 155271261 8.0E-06 TAGATAAGACCAGC 14 GSC_homeodomain_full_monomeric_10_1 SELEX - 155275806 155275815 2.0E-06 GCTAATCCCT 10 ESRRB_nuclearreceptor_DBD_monomeric_11_1 SELEX + 155266680 155266690 3.0E-06 TCAAGGTCACC 11 HOXC10_homeodomain_DBD_monomeric_10_3 SELEX + 155274558 155274567 8.0E-06 ATCATTAAAA 10 THRB_nuclearreceptor_DBD_dimeric_19_1 SELEX + 155266671 155266689 4.0E-06 CTGTTCTTGTCAAGGTCAC 19 THRB_nuclearreceptor_DBD_dimeric_19_1 SELEX - 155266671 155266689 5.0E-06 GTGACCTTGACAAGAACAG 19 HNF1B_homeodomain_full_dimeric_15_1 SELEX + 155274553 155274567 0.0E+00 AGTTAATCATTAAAA 15 HNF1B_homeodomain_full_dimeric_15_1 SELEX - 155274553 155274567 0.0E+00 TTTTAATGATTAACT 15 DPRX_homeodomain_DBD_monomeric_10_1 SELEX + 155275806 155275815 6.0E-06 AGGGATTAGC 10 HNF1A_MA0046.1 JASPAR + 155274553 155274566 0.0E+00 AGTTAATCATTAAA 14 V_MYB_Q6_M00183 TRANSFAC - 155274550 155274559 5.0E-06 ATTAACTGGC 10 V_CDP_03_M01342 TRANSFAC + 155274550 155274566 8.0E-06 GCCAGTTAATCATTAAA 17 V_DBX1_01_M01483 TRANSFAC + 155274552 155274568 2.0E-06 CAGTTAATCATTAAAAT 17 V_TCF3_01_M01594 TRANSFAC + 155271467 155271479 5.0E-06 TCTTTGTACTTTA 13 V_BCL6_01_M01183 TRANSFAC + 155271379 155271394 1.0E-06 TTTCCTGATAAATTTT 16 V_ERR3_Q2_01_M02094 TRANSFAC + 155266678 155266690 1.0E-06 TGTCAAGGTCACC 13 V_COE1_Q6_M01871 TRANSFAC + 155275801 155275814 1.0E-06 TCCCAAGGGATTAG 14 V_LRH1_Q5_01_M02098 TRANSFAC + 155266678 155266688 4.0E-06 TGTCAAGGTCA 11 V_IRF_Q6_01_M00972 TRANSFAC - 155274520 155274530 4.0E-06 AAAACAGAAAG 11 V_EVI1_02_M00079 TRANSFAC - 155271250 155271260 5.0E-06 AGATAAGACCA 11 V_EAR2_Q2_M01728 TRANSFAC + 155271464 155271477 5.0E-06 TTTTCTTTGTACTT 14 V_CUX1_03_M02958 TRANSFAC + 155274550 155274566 8.0E-06 GCCAGTTAATCATTAAA 17 V_GATA_C_M00203 TRANSFAC - 155271250 155271260 3.0E-06 AGATAAGACCA 11 V_GKLF_02_M01588 TRANSFAC - 155271517 155271528 8.0E-06 GCCCCACCCTAC 12 V_GKLF_02_M01588 TRANSFAC + 155275723 155275734 7.0E-06 ACCACGCCCAGC 12 V_PITX2_Q6_M02114 TRANSFAC - 155275703 155275712 9.0E-06 TGTAATTCCA 10 V_CMYB_Q5_M01821 TRANSFAC - 155275765 155275775 5.0E-06 CCCAACTGGTT 11 V_AP4_Q6_02_M01860 TRANSFAC + 155275730 155275742 2.0E-06 CCAGCTGTGGTCT 13 V_HOXD13_01_M01404 TRANSFAC + 155274556 155274571 8.0E-06 TAATCATTAAAATCCA 16 V_AR_03_M00956 TRANSFAC + 155271153 155271179 1.0E-05 GCTGCAGGGATGATATGTTCTCCTGGA 27 V_HNF1_C_M00206 TRANSFAC + 155274553 155274569 0.0E+00 AGTTAATCATTAAAATC 17 V_HNF6_Q6_M00639 TRANSFAC + 155274563 155274574 6.0E-06 TAAAATCCATAG 12 V_HELIOSA_02_M01004 TRANSFAC - 155271377 155271387 7.0E-06 ATCAGGAAAAA 11 V_TCF3_04_M02816 TRANSFAC - 155271463 155271479 3.0E-06 TAAAGTACAAAGAAAAT 17 V_DBX2_01_M01360 TRANSFAC - 155274555 155274570 7.0E-06 GGATTTTAATGATTAA 16 V_PR_01_M00954 TRANSFAC + 155271153 155271179 4.0E-06 GCTGCAGGGATGATATGTTCTCCTGGA 27 V_ARID5A_03_M02736 TRANSFAC - 155275740 155275753 6.0E-06 TCAATATTGCCAGA 14 V_HNF1_Q6_M00790 TRANSFAC - 155274551 155274568 0.0E+00 ATTTTAATGATTAACTGG 18 V_HNF1_Q6_M00790 TRANSFAC + 155274552 155274569 1.0E-06 CAGTTAATCATTAAAATC 18 V_ZBP89_Q4_M01816 TRANSFAC + 155271320 155271329 4.0E-06 CCCTCCCCCA 10 V_HNF1B_04_M02266 TRANSFAC - 155274554 155274565 0.0E+00 TTAATGATTAAC 12 V_HNF1_Q6_01_M01011 TRANSFAC + 155274550 155274570 3.0E-06 GCCAGTTAATCATTAAAATCC 21 V_OCT1_04_M00138 TRANSFAC + 155274553 155274575 5.0E-06 AGTTAATCATTAAAATCCATAGT 23 V_GR_01_M00955 TRANSFAC + 155271153 155271179 8.0E-06 GCTGCAGGGATGATATGTTCTCCTGGA 27 V_TEL2_Q6_M00678 TRANSFAC + 155274602 155274611 8.0E-06 ACACTTCCTG 10 V_TCF7_03_M02817 TRANSFAC - 155271463 155271479 1.0E-06 TAAAGTACAAAGAAAAT 17 V_CETS1P54_01_M00032 TRANSFAC - 155274603 155274612 9.0E-06 ACAGGAAGTG 10 V_MZF1_02_M00084 TRANSFAC + 155274500 155274512 6.0E-06 GAAGTAGGGGGAA 13 V_KAISO_01_M01119 TRANSFAC - 155275811 155275820 4.0E-06 CTCCTGCTAA 10 V_HOXD9_Q2_M01834 TRANSFAC + 155274557 155274566 5.0E-06 AATCATTAAA 10 V_SF1_Q6_01_M01132 TRANSFAC - 155266680 155266688 3.0E-06 TGACCTTGA 9 V_AP4_01_M00005 TRANSFAC + 155275726 155275743 1.0E-06 ACGCCCAGCTGTGGTCTG 18 V_MRG2_01_M01395 TRANSFAC - 155274526 155274541 5.0E-06 TTTAGCCTGTCAAAAC 16 V_IPF1_05_M01255 TRANSFAC + 155274557 155274568 0.0E+00 AATCATTAAAAT 12 V_HNF1_01_M00132 TRANSFAC + 155274553 155274567 0.0E+00 AGTTAATCATTAAAA 15 V_ERR1_Q2_M00511 TRANSFAC + 155266677 155266690 6.0E-06 TTGTCAAGGTCACC 14 V_ERR2_01_M01589 TRANSFAC + 155266680 155266691 2.0E-06 TCAAGGTCACCA 12 V_ESRRA_03_M02748 TRANSFAC + 155266677 155266693 7.0E-06 TTGTCAAGGTCACCAAG 17 V_SMAD_Q6_01_M00974 TRANSFAC + 155274572 155274582 1.0E-06 TAGTCAGACAG 11 V_ZFP281_01_M01597 TRANSFAC - 155271319 155271329 9.0E-06 TGGGGGAGGGA 11 V_IRF1_Q6_01_M01881 TRANSFAC + 155274518 155274531 6.0E-06 AGCTTTCTGTTTTG 14 V_ZFP281_04_M02831 TRANSFAC - 155271570 155271584 4.0E-06 AACCCTCCCCCCACC 15 V_ZFP281_04_M02831 TRANSFAC - 155271571 155271585 3.0E-06 TAACCCTCCCCCCAC 15 V_ERR1_Q2_01_M02093 TRANSFAC + 155266681 155266691 7.0E-06 CAAGGTCACCA 11 V_SOX18_04_M02905 TRANSFAC + 155274534 155274549 5.0E-06 AGGCTAAATTTGAGAA 16 V_HNF1A_Q5_M02013 TRANSFAC + 155274553 155274563 0.0E+00 AGTTAATCATT 11 V_SMAD3_Q6_M00701 TRANSFAC - 155274573 155274581 6.0E-06 TGTCTGACT 9 V_IPF1_Q4_01_M01013 TRANSFAC + 155274555 155274569 4.0E-06 TTAATCATTAAAATC 15 V_SOX2_Q6_M01272 TRANSFAC - 155271540 155271555 5.0E-06 ATCCCTTTTGTCTTTC 16 V_PR_02_M00957 TRANSFAC + 155271153 155271179 7.0E-06 GCTGCAGGGATGATATGTTCTCCTGGA 27 V_BRN3C_01_M01408 TRANSFAC - 155274555 155274570 1.0E-05 GGATTTTAATGATTAA 16 V_HNF1A_01_M02162 TRANSFAC + 155274553 155274566 0.0E+00 AGTTAATCATTAAA 14 V_SEF1_C_M00214 TRANSFAC + 155275723 155275741 1.0E-06 ACCACGCCCAGCTGTGGTC 19 V_SMAD1_01_M01590 TRANSFAC + 155271541 155271552 5.0E-06 AAAGACAAAAGG 12 V_NANOG_02_M01247 TRANSFAC - 155271462 155271481 8.0E-06 AGTAAAGTACAAAGAAAATG 20 V_NANOG_02_M01247 TRANSFAC + 155271537 155271556 8.0E-06 GAAGAAAGACAAAAGGGATC 20 V_T3RALPHA_Q6_M01724 TRANSFAC - 155275877 155275887 5.0E-06 TTTCAGGTCAA 11 V_ER_Q6_M00191 TRANSFAC + 155275867 155275885 1.0E-06 GACAGACACTTTGACCTGA 19

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.