Search TFs or Genes

Construction and Validation

Optimal Promoter Size

Download

Citation and Contact

MGMT Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 4255 O-6-methylguanine-DNA methyltransferase chr10 + 131260453 - 131265953 131265453 Transcription Factor Binding Sites   Download all TFBS in the MGMT promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints HSF2_HSF_DBD_trimeric_13_1 SELEX - 131265913 131265925 1.0E-06 TTCTGGAAGCTTC 13 Foxa2_MA0047.2 JASPAR + 131260671 131260682 8.0E-06 TGTTTACATACA 12 CENPB_CENPB_full_monomeric_15_1 SELEX - 131264991 131265005 7.0E-06 CCCGCTTAGTGAGAA 15 IRF7_IRF_DBD_dimeric_14_1 SELEX - 131270227 131270240 4.0E-06 ACAAAACTGAAAAC 14 YY2_C2H2_full_dimeric_12_1 SELEX + 131265432 131265443 4.0E-06 CCACGCCGCCAT 12 KLF16_C2H2_DBD_monomeric_11_1 SELEX + 131265366 131265376 1.0E-05 GCCCCGCCCCC 11 KLF16_C2H2_DBD_monomeric_11_1 SELEX + 131265458 131265468 1.0E-05 GCCCCGCCCCC 11 FOXA1_MA0148.1 JASPAR + 131260671 131260681 5.0E-06 TGTTTACATAC 11 HSF1_HSF_full_trimeric_13_1 SELEX - 131265913 131265925 1.0E-06 TTCTGGAAGCTTC 13 FOXC2_forkhead_DBD_monomeric_12_1 SELEX - 131260669 131260680 1.0E-06 TATGTAAACAAG 12 POU3F2_POU_DBD_monomeric_13_1 SELEX + 131260673 131260685 7.0E-06 TTTACATACATTA 13 FOXL1_forkhead_full_dimeric_13_1 SELEX - 131260666 131260678 2.0E-06 TGTAAACAAGCAA 13 FOXL1_forkhead_full_dimeric_13_1 SELEX - 131260670 131260682 6.0E-06 TGTATGTAAACAA 13 FOXO3_MA0157.1 JASPAR - 131260671 131260678 7.0E-06 TGTAAACA 8 TFAP2B_TFAP_DBD_dimeric_11_1 SELEX + 131265128 131265138 3.0E-06 AGCCTCAGGCG 11 TFAP2B_TFAP_DBD_dimeric_11_1 SELEX - 131265128 131265138 7.0E-06 CGCCTGAGGCT 11 FOXC1_forkhead_DBD_monomeric_11_1 SELEX - 131260670 131260680 1.0E-06 TATGTAAACAA 11 FOXO1_forkhead_DBD_monomeric_8_1 SELEX - 131260670 131260677 7.0E-06 GTAAACAA 8 TFAP2A_TFAP_DBD_dimeric_11_1 SELEX + 131265128 131265138 3.0E-06 AGCCTCAGGCG 11 TFAP2A_TFAP_DBD_dimeric_11_1 SELEX - 131265128 131265138 8.0E-06 CGCCTGAGGCT 11 ZNF238_C2H2_full_monomeric_13_1 SELEX + 131270252 131270264 4.0E-06 GATGCAGATGTTA 13 TCF7L1_HMG_full_monomeric_12_1 SELEX + 131262638 131262649 9.0E-06 AGACCTCAAAGG 12 TEAD1_TEA_full_monomeric_10_1 SELEX + 131260688 131260697 3.0E-06 TACATTCCTT 10 RUNX3_RUNX_full_monomeric_10_1 SELEX - 131270236 131270245 2.0E-06 TAACCACAAA 10 LEF1_HMG_DBD_monomeric_15_1 SELEX + 131260523 131260537 8.0E-06 CAACATCAAACAAAA 15 IRF1_MA0050.1 JASPAR - 131270227 131270238 5.0E-06 AAAACTGAAAAC 12 RUNX2_RUNX_DBD_monomeric_9_1 SELEX - 131270237 131270245 1.0E-05 TAACCACAA 9 Foxc1_forkhead_DBD_dimeric_11_1 SELEX - 131260667 131260677 5.0E-06 GTAAACAAGCA 11 HSF4_HSF_DBD_trimeric_13_1 SELEX - 131265913 131265925 1.0E-06 TTCTGGAAGCTTC 13 SP1_MA0079.2 JASPAR + 131265367 131265376 7.0E-06 CCCCGCCCCC 10 SP1_MA0079.2 JASPAR + 131265459 131265468 7.0E-06 CCCCGCCCCC 10 TEAD3_TEA_DBD_dimeric_17_1 SELEX + 131260680 131260696 1.0E-06 ACATTATGTACATTCCT 17 TEAD3_TEA_DBD_dimeric_17_1 SELEX + 131260794 131260810 2.0E-06 AAATTCCACAAATAGCT 17 TFAP2C_TFAP_full_dimeric_11_1 SELEX + 131265128 131265138 4.0E-06 AGCCTCAGGCG 11 TFAP2C_TFAP_full_dimeric_11_1 SELEX - 131265128 131265138 9.0E-06 CGCCTGAGGCT 11 TEAD1_TEA_full_dimeric_17_1 SELEX + 131260680 131260696 1.0E-06 ACATTATGTACATTCCT 17 TEAD1_TEA_full_dimeric_17_1 SELEX + 131260794 131260810 1.0E-06 AAATTCCACAAATAGCT 17 IRF4_IRF_full_dimeric_15_1 SELEX - 131270226 131270240 5.0E-06 ACAAAACTGAAAACT 15 TEAD4_TEA_DBD_monomeric_10_1 SELEX + 131260688 131260697 4.0E-06 TACATTCCTT 10 RUNX1_MA0002.2 JASPAR + 131270235 131270245 2.0E-06 TTTTGTGGTTA 11 FOXB1_forkhead_full_monomeric_9_1 SELEX - 131260670 131260678 2.0E-06 TGTAAACAA 9 FOXO3_forkhead_full_monomeric_8_1 SELEX - 131260670 131260677 7.0E-06 GTAAACAA 8 ELF5_MA0136.1 JASPAR + 131265983 131265991 2.0E-06 TATTTCCTT 9 FOXC1_forkhead_DBD_dimeric_13_1 SELEX - 131260667 131260679 2.0E-06 ATGTAAACAAGCA 13 FOXB1_forkhead_DBD_monomeric_11_1 SELEX - 131260670 131260680 1.0E-06 TATGTAAACAA 11 NFIA_NFI_full_monomeric_10_1 SELEX - 131265107 131265116 5.0E-06 TTTGCCAAAT 10 Tcfap2a_TFAP_DBD_dimeric_11_1 SELEX + 131265128 131265138 4.0E-06 AGCCTCAGGCG 11 Tcfap2a_TFAP_DBD_dimeric_11_1 SELEX - 131265128 131265138 4.0E-06 CGCCTGAGGCT 11 POU4F1_POU_DBD_monomeric_14_1 SELEX - 131260677 131260690 5.0E-06 GTACATAATGTATG 14 V_FOXP1_01_M00987 TRANSFAC + 131270211 131270230 0.0E+00 TTATTATTGCTTTTGAGTTT 20 V_CEBPG_Q6_M00622 TRANSFAC - 131260486 131260498 3.0E-06 CTCATTACAAAGT 13 V_HNF3B_01_M00131 TRANSFAC + 131260666 131260680 6.0E-06 TTGCTTGTTTACATA 15 V_KLF15_Q2_M01714 TRANSFAC - 131265335 131265348 9.0E-06 GAGCTGGGGCGGAG 14 V_STAT3_01_M00225 TRANSFAC - 131260458 131260478 9.0E-06 ATCCATTTTCGGGAAGGGCTT 21 V_TCFE2A_04_M02927 TRANSFAC + 131270251 131270267 4.0E-06 AGATGCAGATGTTACCA 17 V_FOXO3_02_M02270 TRANSFAC - 131260671 131260678 7.0E-06 TGTAAACA 8 V_OSF2_Q6_M00731 TRANSFAC - 131270236 131270243 1.0E-05 ACCACAAA 8 V_MAX_Q6_M01830 TRANSFAC - 131265046 131265057 2.0E-06 CCTGCCACGTGC 12 V_FOXA2_04_M02749 TRANSFAC - 131260666 131260682 1.0E-06 TGTATGTAAACAAGCAA 17 V_HMGIY_Q3_M01010 TRANSFAC + 131260857 131260871 7.0E-06 CATGCATTTTCTCTT 15 V_HP1SITEFACTOR_Q6_M00725 TRANSFAC + 131260706 131260717 8.0E-06 AATTGTCTAAAG 12 V_AML3_Q6_M01856 TRANSFAC - 131270237 131270244 1.0E-05 AACCACAA 8 V_FOXO4_02_M00476 TRANSFAC + 131260667 131260680 4.0E-06 TGCTTGTTTACATA 14 V_TCF4_Q5_01_M02033 TRANSFAC - 131260692 131260701 1.0E-06 ATCAAAGGAA 10 V_CBF_02_M01080 TRANSFAC + 131270233 131270248 1.0E-05 AGTTTTGTGGTTATGA 16 V_SP1_Q6_01_M00931 TRANSFAC - 131265318 131265327 7.0E-06 GGGGCGGGGT 10 V_SP1_Q6_01_M00931 TRANSFAC - 131265366 131265375 4.0E-06 GGGGCGGGGC 10 V_SP1_Q6_01_M00931 TRANSFAC - 131265424 131265433 7.0E-06 GGGGCGGGGT 10 V_SP1_Q6_01_M00931 TRANSFAC - 131265458 131265467 4.0E-06 GGGGCGGGGC 10 V_IRF_Q6_01_M00972 TRANSFAC - 131270228 131270238 1.0E-06 AAAACTGAAAA 11 V_RP58_01_M00532 TRANSFAC - 131270254 131270265 9.0E-06 GTAACATCTGCA 12 V_OCT1_01_M00135 TRANSFAC - 131265953 131265971 8.0E-06 CTAAGTATGCTAAAGGGTT 19 V_CEBP_01_M00159 TRANSFAC - 131260632 131260644 3.0E-06 TATTTGGATACGT 13 V_FOXO3A_Q1_M01137 TRANSFAC - 131260667 131260678 5.0E-06 TGTAAACAAGCA 12 V_GABPA_04_M02858 TRANSFAC - 131265131 131265146 7.0E-06 CCAGCTTCCGCCTGAG 16 V_FOXJ1_03_M02750 TRANSFAC - 131260665 131260680 7.0E-06 TATGTAAACAAGCAAA 16 V_SP1_03_M02281 TRANSFAC + 131265367 131265376 7.0E-06 CCCCGCCCCC 10 V_SP1_03_M02281 TRANSFAC + 131265459 131265468 7.0E-06 CCCCGCCCCC 10 V_AFP1_Q6_M00616 TRANSFAC - 131270208 131270218 6.0E-06 AATAATAACAT 11 V_SP1_02_M01303 TRANSFAC - 131265317 131265327 3.0E-06 GGGGCGGGGTG 11 V_SP1_02_M01303 TRANSFAC - 131265423 131265433 8.0E-06 GGGGCGGGGTC 11 V_AIRE_02_M01000 TRANSFAC - 131260626 131260650 9.0E-06 TGTATGTATTTGGATACGTTGGCTT 25 V_CMYC_02_M01154 TRANSFAC - 131265044 131265055 6.0E-06 TGCCACGTGCCC 12 V_GC_01_M00255 TRANSFAC - 131265343 131265356 6.0E-06 CGGGGGCGGAGCTG 14 V_GC_01_M00255 TRANSFAC - 131265364 131265377 8.0E-06 CGGGGGCGGGGCCG 14 V_GC_01_M00255 TRANSFAC - 131265456 131265469 8.0E-06 CGGGGGCGGGGCCG 14 V_SOX7_03_M02807 TRANSFAC - 131260698 131260719 2.0E-06 AACTTTAGACAATTGACTATCA 22 V_TCF3_04_M02816 TRANSFAC + 131260522 131260538 7.0E-06 CCAACATCAAACAAAAT 17 V_FREAC3_01_M00291 TRANSFAC - 131260667 131260682 1.0E-06 TGTATGTAAACAAGCA 16 V_RUNX1_01_M02257 TRANSFAC + 131270235 131270245 2.0E-06 TTTTGTGGTTA 11 V_XFD3_01_M00269 TRANSFAC - 131260667 131260680 8.0E-06 TATGTAAACAAGCA 14 V_STAT1_01_M00224 TRANSFAC + 131260458 131260478 8.0E-06 AAGCCCTTCCCGAAAATGGAT 21 V_AML2_01_M01759 TRANSFAC - 131270237 131270244 1.0E-05 AACCACAA 8 V_KROX_Q6_M00982 TRANSFAC + 131265368 131265381 9.0E-06 CCCGCCCCCGCGCG 14 V_KROX_Q6_M00982 TRANSFAC + 131265460 131265473 1.0E-06 CCCGCCCCCGCGCC 14 V_IRX4_01_M01410 TRANSFAC + 131270201 131270217 3.0E-06 ACCCAACATGTTATTAT 17 V_HOXB9_01_M01426 TRANSFAC - 131270208 131270223 9.0E-06 AAAGCAATAATAACAT 16 V_SP1_Q6_M00196 TRANSFAC - 131265317 131265329 4.0E-06 GAGGGGCGGGGTG 13 V_SP1_Q6_M00196 TRANSFAC - 131265365 131265377 1.0E-06 CGGGGGCGGGGCC 13 V_SP1_Q6_M00196 TRANSFAC - 131265457 131265469 1.0E-06 CGGGGGCGGGGCC 13 V_FOXK1_04_M02856 TRANSFAC - 131270206 131270220 4.0E-06 GCAATAATAACATGT 15 V_HNF3A_01_M01261 TRANSFAC - 131260670 131260679 1.0E-06 ATGTAAACAA 10 V_EGR1_Q6_M01873 TRANSFAC - 131265348 131265357 4.0E-06 GCGGGGGCGG 10 V_EGR1_Q6_M01873 TRANSFAC - 131265369 131265378 4.0E-06 GCGGGGGCGG 10 V_EGR1_Q6_M01873 TRANSFAC - 131265461 131265470 4.0E-06 GCGGGGGCGG 10 V_IRF_Q6_M00772 TRANSFAC + 131270224 131270238 5.0E-06 TGAGTTTTCAGTTTT 15 V_NKX52_01_M01315 TRANSFAC - 131270208 131270224 5.0E-06 AAAAGCAATAATAACAT 17 V_MUSCLE_INI_B_M00321 TRANSFAC + 131265432 131265452 9.0E-06 CCACGCCGCCATCCCCGTGCC 21 V_PEBP_Q6_M00984 TRANSFAC - 131270233 131270247 1.0E-06 CATAACCACAAAACT 15 V_ZIC3_05_M02941 TRANSFAC - 131266286 131266300 1.0E-05 GATCTCAGCAGGCAT 15 V_TCF7_03_M02817 TRANSFAC + 131260522 131260538 4.0E-06 CCAACATCAAACAAAAT 17 V_KLF7_03_M02773 TRANSFAC + 131265421 131265436 6.0E-06 TAGACCCCGCCCCACG 16 V_XFD2_01_M00268 TRANSFAC - 131260667 131260680 3.0E-06 TATGTAAACAAGCA 14 V_STAF_02_M00264 TRANSFAC + 131265975 131265995 9.0E-06 GAGTCCCATATTTCCTTCCTG 21 V_POU6F1_01_M00465 TRANSFAC + 131260676 131260686 5.0E-06 ACATACATTAT 11 V_SP1_01_M00008 TRANSFAC - 131265318 131265327 3.0E-06 GGGGCGGGGT 10 V_SP1_01_M00008 TRANSFAC - 131265424 131265433 3.0E-06 GGGGCGGGGT 10 V_IRX3_01_M01318 TRANSFAC - 131270200 131270216 1.0E-05 TAATAACATGTTGGGTT 17 V_IRX3_01_M01318 TRANSFAC + 131270201 131270217 7.0E-06 ACCCAACATGTTATTAT 17 V_OCT4_02_M01124 TRANSFAC + 131260864 131260878 9.0E-06 TTTCTCTTGCAGGTC 15 V_IRX5_01_M01472 TRANSFAC - 131270200 131270216 3.0E-06 TAATAACATGTTGGGTT 17 V_IRX5_01_M01472 TRANSFAC + 131270201 131270217 9.0E-06 ACCCAACATGTTATTAT 17 V_SP4_Q5_M01273 TRANSFAC + 131265366 131265376 1.0E-06 GCCCCGCCCCC 11 V_SP4_Q5_M01273 TRANSFAC + 131265458 131265468 1.0E-06 GCCCCGCCCCC 11 V_FREAC2_01_M00290 TRANSFAC - 131260667 131260682 2.0E-06 TGTATGTAAACAAGCA 16 V_HFH8_01_M00294 TRANSFAC + 131260668 131260680 9.0E-06 GCTTGTTTACATA 13 V_IRX3_02_M01485 TRANSFAC + 131270201 131270217 6.0E-06 ACCCAACATGTTATTAT 17 V_FOXL1_02_M02857 TRANSFAC + 131260524 131260539 4.0E-06 AACATCAAACAAAATC 16 V_FOXL1_04_M02753 TRANSFAC - 131260666 131260682 1.0E-06 TGTATGTAAACAAGCAA 17 V_AIRE_01_M00999 TRANSFAC - 131260623 131260648 2.0E-06 TATGTATTTGGATACGTTGGCTTGAA 26 V_TCF7_04_M02921 TRANSFAC + 131260444 131260458 5.0E-06 ATGTGTTACAAATAA 6 V_FOXO3_01_M00477 TRANSFAC + 131260667 131260680 0.0E+00 TGCTTGTTTACATA 14 V_FOXA2_03_M02260 TRANSFAC + 131260671 131260682 8.0E-06 TGTTTACATACA 12 V_PBX1_03_M01017 TRANSFAC + 131260525 131260536 2.0E-06 ACATCAAACAAA 12 V_EGR1_06_M02744 TRANSFAC + 131265347 131265360 4.0E-06 TCCGCCCCCGCGCG 14 V_EGR1_06_M02744 TRANSFAC + 131265368 131265381 7.0E-06 CCCGCCCCCGCGCG 14 V_EGR1_06_M02744 TRANSFAC + 131265460 131265473 9.0E-06 CCCGCCCCCGCGCC 14 V_IRX2_01_M01405 TRANSFAC - 131270200 131270216 4.0E-06 TAATAACATGTTGGGTT 17 V_HSF_Q6_M00641 TRANSFAC - 131265913 131265925 5.0E-06 TTCTGGAAGCTTC 13 V_IRF1_Q6_01_M01881 TRANSFAC + 131270226 131270239 2.0E-06 AGTTTTCAGTTTTG 14 V_DMRT2_01_M01147 TRANSFAC - 131260470 131260485 1.0E-06 GTTTTTGATCCATTTT 16 V_HFH3_01_M00289 TRANSFAC + 131260668 131260680 5.0E-06 GCTTGTTTACATA 13 V_HSF2_02_M01244 TRANSFAC + 131265913 131265925 1.0E-06 GAAGCTTCCAGAA 13 V_FOXJ2_01_M00422 TRANSFAC - 131260666 131260683 1.0E-05 ATGTATGTAAACAAGCAA 18 V_SOX2_Q6_M01272 TRANSFAC + 131260482 131260497 2.0E-06 AAACACTTTGTAATGA 16 V_IRF1_01_M00062 TRANSFAC - 131270227 131270239 1.0E-06 CAAAACTGAAAAC 13 V_SP1_Q2_01_M00933 TRANSFAC + 131265319 131265328 7.0E-06 CCCCGCCCCT 10 V_SP1_Q2_01_M00933 TRANSFAC + 131265367 131265376 4.0E-06 CCCCGCCCCC 10 V_SP1_Q2_01_M00933 TRANSFAC + 131265459 131265468 4.0E-06 CCCCGCCCCC 10 V_FOXO4_01_M00472 TRANSFAC - 131260667 131260677 6.0E-06 GTAAACAAGCA 11 V_AP2ALPHA_02_M01045 TRANSFAC - 131265126 131265140 1.0E-05 TCCGCCTGAGGCTCT 15 V_ELF5_04_M02241 TRANSFAC + 131265983 131265991 2.0E-06 TATTTCCTT 9 V_MAFK_04_M02880 TRANSFAC - 131260856 131260870 6.0E-06 AGAGAAAATGCATGG 15 V_AP2ALPHA_03_M01047 TRANSFAC + 131265126 131265140 3.0E-06 AGAGCCTCAGGCGGA 15 V_AP2ALPHA_03_M01047 TRANSFAC - 131265126 131265140 3.0E-06 TCCGCCTGAGGCTCT 15 V_SP1_Q4_01_M00932 TRANSFAC - 131265365 131265377 1.0E-06 CGGGGGCGGGGCC 13 V_SP1_Q4_01_M00932 TRANSFAC - 131265457 131265469 1.0E-06 CGGGGGCGGGGCC 13 V_TCF11MAFG_01_M00284 TRANSFAC - 131262663 131262684 5.0E-06 ATAGGATGACAGTGCAGGACTG 22 V_IRXB3_01_M01377 TRANSFAC - 131270200 131270216 5.0E-06 TAATAACATGTTGGGTT 17 V_IRXB3_01_M01377 TRANSFAC + 131270201 131270217 7.0E-06 ACCCAACATGTTATTAT 17 V_FOXK1_03_M02752 TRANSFAC - 131260666 131260682 0.0E+00 TGTATGTAAACAAGCAA 17 V_ZIC1_05_M02939 TRANSFAC - 131266286 131266300 9.0E-06 GATCTCAGCAGGCAT 15

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.