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APOE Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 348 apolipoprotein E chr19 + 45404038 - 45409538 45409038 Transcription Factor Binding Sites   Download all TFBS in the APOE promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints CTCF_MA0139.1 JASPAR + 45407029 45407047 1.0E-06 CCGCCTGCAGGGGGCGCCA 19 RARB_nuclearreceptor_full_dimeric_16_1 SELEX + 45407193 45407208 3.0E-06 TAGGGTCTCAAGGTCA 16 IRF7_IRF_DBD_dimeric_14_1 SELEX - 45413571 45413584 2.0E-06 AAAAAAATGAAAAT 14 ALX3_homeodomain_full_monomeric_10_1 SELEX - 45409022 45409031 8.0E-06 TCCAATTATA 10 SPIC_ETS_full_monomeric_14_1 SELEX - 45413704 45413717 9.0E-06 GAAAACAGGAAGCC 14 ZNF713_C2H2_full_monomeric_17_1 SELEX - 45413550 45413566 4.0E-06 TAGAATAAAGGCACCAA 17 KLF16_C2H2_DBD_monomeric_11_1 SELEX - 45409929 45409939 1.0E-05 GCCCCGCCCCC 11 ZNF75A_C2H2_DBD_monomeric_12_1 SELEX - 45406930 45406941 7.0E-06 TTTTTTCCCACG 12 SRY_HMG_DBD_dimeric_16_1 SELEX + 45413567 45413582 1.0E-05 AGCTATTTTCATTTTT 16 HNF1B_MA0153.1 JASPAR - 45409689 45409700 5.0E-06 TCCCTATTTAAC 12 EWSR1-FLI1_MA0149.1 JASPAR - 45413701 45413718 9.0E-06 GGAAAACAGGAAGCCAGA 18 Esrrb_MA0141.1 JASPAR + 45407197 45407208 2.0E-06 GTCTCAAGGTCA 12 NFYA_MA0060.1 JASPAR + 45409859 45409874 6.0E-06 ACTGGCCAATCACAGG 16 GATA5_GATA_DBD_monomeric_8_1 SELEX + 45409666 45409673 7.0E-06 AGATAAGA 8 TFAP2A_TFAP_DBD_dimeric_11_1 SELEX - 45408929 45408939 8.0E-06 TGCCCCAGGCA 11 GATA4_GATA_DBD_monomeric_8_1 SELEX + 45409666 45409673 7.0E-06 AGATAAGA 8 IRF7_IRF_DBD_trimeric_17_1 SELEX - 45413565 45413581 3.0E-06 AAAATGAAAATAGCTTA 17 ZNF238_C2H2_full_monomeric_13_1 SELEX - 45407820 45407832 2.0E-06 ATCCCAGATGTTT 13 TCF7L1_HMG_full_monomeric_12_1 SELEX - 45413729 45413740 7.0E-06 AGAGATAAAAGA 12 RUNX3_RUNX_full_monomeric_10_1 SELEX + 45408138 45408147 3.0E-06 AAACCACAAT 10 IRF1_MA0050.1 JASPAR + 45407849 45407860 7.0E-06 GAAAGTGACAGC 12 IRF1_MA0050.1 JASPAR - 45413571 45413582 4.0E-06 AAAAATGAAAAT 12 RUNX2_RUNX_DBD_monomeric_9_1 SELEX + 45408138 45408146 8.0E-06 AAACCACAA 9 POU6F2_POU_DBD_dimeric_16_1 SELEX + 45409480 45409495 2.0E-06 TGAATTAGCTCATAAA 16 POU6F2_POU_DBD_dimeric_16_1 SELEX - 45409480 45409495 1.0E-06 TTTATGAGCTAATTCA 16 SP1_MA0079.2 JASPAR - 45408994 45409003 3.0E-06 CCCCTCCCCC 10 SP1_MA0079.2 JASPAR - 45409929 45409938 7.0E-06 CCCCGCCCCC 10 HNF4A_nuclearreceptor_full_dimeric_16_1 SELEX - 45407243 45407258 5.0E-06 AGGGACAAAGTCCTCT 16 HNF4A_nuclearreceptor_full_dimeric_16_1 SELEX - 45409602 45409617 2.0E-06 GGGTTCAAATTCCATC 16 SP4_C2H2_full_monomeric_17_1 SELEX - 45409926 45409942 0.0E+00 CAAGCCCCGCCCCCATA 17 ESRRG_nuclearreceptor_full_monomeric_10_1 SELEX + 45407200 45407209 3.0E-06 TCAAGGTCAC 10 Tcf7_HMG_DBD_monomeric_12_1 SELEX - 45413729 45413740 9.0E-06 AGAGATAAAAGA 12 NR2F1_nuclearreceptor_DBD_dimeric_16_1 SELEX + 45407194 45407209 2.0E-06 AGGGTCTCAAGGTCAC 16 Gata1_MA0035.2 JASPAR + 45409664 45409674 7.0E-06 GGAGATAAGAG 11 GATA3_GATA_full_monomeric_8_1 SELEX + 45409666 45409673 7.0E-06 AGATAAGA 8 Esrra_nuclearreceptor_DBD_monomeric_11_1 SELEX + 45407199 45407209 5.0E-06 CTCAAGGTCAC 11 Evi1_MA0029.1 JASPAR - 45413724 45413737 9.0E-06 GATAAAAGATAGAA 14 ESRRB_nuclearreceptor_DBD_monomeric_11_1 SELEX + 45407200 45407210 2.0E-06 TCAAGGTCACT 11 TEAD4_TEA_DBD_monomeric_10_1 SELEX - 45409603 45409612 8.0E-06 CAAATTCCAT 10 SPI1_ETS_full_monomeric_14_1 SELEX - 45413704 45413717 1.0E-05 GAAAACAGGAAGCC 14 RUNX1_MA0002.2 JASPAR - 45408138 45408148 5.0E-06 TATTGTGGTTT 11 Nr2f6_nuclearreceptor_DBD_dimeric_15_1 SELEX + 45407194 45407208 2.0E-06 AGGGTCTCAAGGTCA 15 Foxj3_forkhead_DBD_dimeric_13_1 SELEX - 45413570 45413582 7.0E-06 AAAAATGAAAATA 13 RARA_nuclearreceptor_full_dimeric_15_1 SELEX + 45407194 45407208 7.0E-06 AGGGTCTCAAGGTCA 15 TEAD1_MA0090.1 JASPAR + 45409911 45409922 7.0E-06 CACATTCCTGGC 12 IRF2_MA0051.1 JASPAR + 45407848 45407865 8.0E-06 GGAAAGTGACAGCGTCTG 18 V_FOXP1_01_M00987 TRANSFAC + 45413569 45413588 7.0E-06 CTATTTTCATTTTTTTTCTG 20 V_FOXP3_Q4_M00992 TRANSFAC + 45407368 45407384 2.0E-06 GAACTGCTGTGTCAGGG 17 V_TCFE2A_04_M02927 TRANSFAC - 45407141 45407157 0.0E+00 CAGGGCAGATGTTCCGG 17 V_TCFE2A_04_M02927 TRANSFAC - 45407817 45407833 3.0E-06 AATCCCAGATGTTTCAG 17 V_GATA2_02_M00348 TRANSFAC + 45409664 45409673 5.0E-06 GGAGATAAGA 10 V_GATA2_02_M00348 TRANSFAC - 45413731 45413740 5.0E-06 AGAGATAAAA 10 V_SMAD3_Q6_01_M01888 TRANSFAC - 45408826 45408838 3.0E-06 ATACAGACACCCT 13 V_XPF1_Q6_M00684 TRANSFAC + 45407347 45407356 4.0E-06 TCAGAACAAC 10 V_NFY_Q6_M00185 TRANSFAC + 45409861 45409871 6.0E-06 TGGCCAATCAC 11 V_DLX3_01_M01400 TRANSFAC + 45409018 45409034 1.0E-05 GCCCTATAATTGGACAA 17 V_HMGIY_Q3_M01010 TRANSFAC + 45409629 45409643 7.0E-06 GATGGAATTTTCTAT 15 V_EVI1_04_M00081 TRANSFAC - 45413573 45413587 6.0E-06 AGAAAAAAAATGAAA 15 V_ERR3_Q2_01_M02094 TRANSFAC + 45407198 45407210 0.0E+00 TCTCAAGGTCACT 13 V_LRH1_Q5_01_M02098 TRANSFAC + 45407198 45407208 4.0E-06 TCTCAAGGTCA 11 V_AML3_Q6_M01856 TRANSFAC + 45408139 45408146 1.0E-05 AACCACAA 8 V_ETS_B_M00340 TRANSFAC - 45413701 45413714 7.0E-06 AACAGGAAGCCAGA 14 V_STAT_Q6_M00777 TRANSFAC + 45408679 45408691 6.0E-06 TTTCTTTCTGGGA 13 V_IK_Q5_M01169 TRANSFAC - 45413449 45413458 3.0E-06 TTTGGGAGGC 10 V_FOXJ2_02_M00423 TRANSFAC + 45408140 45408153 5.0E-06 ACCACAATACCTGT 14 V_SP1_Q6_01_M00931 TRANSFAC + 45409930 45409939 4.0E-06 GGGGCGGGGC 10 V_IRF_Q6_01_M00972 TRANSFAC - 45413572 45413582 2.0E-06 AAAAATGAAAA 11 V_IRF2_Q6_M01882 TRANSFAC - 45413569 45413584 1.0E-06 AAAAAAATGAAAATAG 16 V_RP58_01_M00532 TRANSFAC + 45407819 45407830 2.0E-06 GAAACATCTGGG 12 V_SP1_03_M02281 TRANSFAC - 45408994 45409003 3.0E-06 CCCCTCCCCC 10 V_SP1_03_M02281 TRANSFAC - 45409929 45409938 7.0E-06 CCCCGCCCCC 10 V_DLX2_01_M01468 TRANSFAC + 45409020 45409035 4.0E-06 CCTATAATTGGACAAG 16 V_SP1_02_M01303 TRANSFAC + 45409304 45409314 5.0E-06 GGGGTGGGGAG 11 V_SP1_02_M01303 TRANSFAC + 45409592 45409602 5.0E-06 GGGGTGGGGGG 11 V_COUPTF_Q6_M01036 TRANSFAC - 45407191 45407213 3.0E-06 GCAAGTGACCTTGAGACCCTACC 23 V_PU1_Q4_M01172 TRANSFAC + 45413698 45413716 2.0E-06 GACTCTGGCTTCCTGTTTT 19 V_LYF1_01_M00141 TRANSFAC - 45413450 45413458 9.0E-06 TTTGGGAGG 9 V_NFY_Q6_01_M00775 TRANSFAC + 45409858 45409870 6.0E-06 GACTGGCCAATCA 13 V_BRN2_01_M00145 TRANSFAC - 45408178 45408193 9.0E-06 CACATGTGAAATGAGA 16 V_TCFAP2E_04_M02926 TRANSFAC - 45413577 45413590 4.0E-06 AGCAGAAAAAAAAT 14 V_TCFAP2E_04_M02926 TRANSFAC - 45413578 45413591 8.0E-06 CAGCAGAAAAAAAA 14 V_HOXA13_03_M01430 TRANSFAC + 45409484 45409499 8.0E-06 TTAGCTCATAAATGGA 16 V_HOXC13_01_M01317 TRANSFAC + 45409484 45409499 3.0E-06 TTAGCTCATAAATGGA 16 V_TAL1_GATA1_01_M02243 TRANSFAC + 45409655 45409672 9.0E-06 TGGGGATGGGGAGATAAG 18 V_TAL1_GATA1_01_M02243 TRANSFAC + 45413143 45413160 1.0E-06 CTGGACTCAAGTGATAAG 18 V_TGIF2_01_M01407 TRANSFAC - 45409834 45409849 6.0E-06 GAGAAACTGTCAATCA 16 V_NFY_C_M00209 TRANSFAC - 45409859 45409872 1.0E-06 TGTGATTGGCCAGT 14 V_TRF1_01_M01237 TRANSFAC - 45408096 45408110 3.0E-06 TTAAGGTTAGGATTC 15 V_TAL1_Q6_M00993 TRANSFAC - 45409315 45409324 3.0E-06 TCCAGCTGCT 10 V_ZNF219_01_M01122 TRANSFAC - 45409703 45409714 9.0E-06 CGCCCCCAACCC 12 V_GC_01_M00255 TRANSFAC + 45409928 45409941 0.0E+00 TGGGGGCGGGGCTT 14 V_MEIS2_01_M01488 TRANSFAC + 45413583 45413598 1.0E-05 TTTCTGCTGTCATTAT 16 V_TGIF_02_M01346 TRANSFAC - 45413583 45413599 2.0E-06 AATAATGACAGCAGAAA 17 V_FKLF_Q5_M01837 TRANSFAC + 45409807 45409816 2.0E-06 GGGGTGGGAG 10 V_ZFP410_03_M02832 TRANSFAC + 45409321 45409337 6.0E-06 TGGACTGGGATGTAAGC 17 V_RUNX1_01_M02257 TRANSFAC - 45408138 45408148 5.0E-06 TATTGTGGTTT 11 V_SP4_03_M02810 TRANSFAC - 45408995 45409011 0.0E+00 TGTCCCGCCCCCTCCCC 17 V_AML2_01_M01759 TRANSFAC + 45408139 45408146 1.0E-05 AACCACAA 8 V_KROX_Q6_M00982 TRANSFAC - 45408995 45409008 0.0E+00 CCCGCCCCCTCCCC 14 V_KROX_Q6_M00982 TRANSFAC - 45409586 45409599 8.0E-06 CCCACCCCCTCCCC 14 V_KROX_Q6_M00982 TRANSFAC - 45409703 45409716 5.0E-06 GCCGCCCCCAACCC 14 V_KROX_Q6_M00982 TRANSFAC - 45409924 45409937 4.0E-06 CCCGCCCCCATACC 14 V_ZBP89_Q4_M01816 TRANSFAC - 45408993 45409002 4.0E-06 CCCTCCCCCA 10 V_SP1_Q6_M00196 TRANSFAC + 45409928 45409940 1.0E-06 TGGGGGCGGGGCT 13 V_HNF1B_04_M02266 TRANSFAC - 45409689 45409700 5.0E-06 TCCCTATTTAAC 12 V_EVI1_01_M00078 TRANSFAC + 45409666 45409681 0.0E+00 AGATAAGAGAAGACCA 16 V_MAZ_Q6_01_M02023 TRANSFAC - 45409953 45409966 8.0E-06 GGGGGAGGAGCGGG 14 V_IRF_Q6_M00772 TRANSFAC + 45413568 45413582 0.0E+00 GCTATTTTCATTTTT 15 V_EGR1_04_M02848 TRANSFAC - 45409047 45409062 8.0E-06 GGCTGAGTAGGACTCA 16 V_SREBP_Q6_M01168 TRANSFAC - 45409775 45409789 7.0E-06 GGCCTCACCCCAGGT 15 V_ISRE_01_M00258 TRANSFAC + 45409841 45409855 5.0E-06 CAGTTTCTCCTTCCC 15 V_NFE4_Q5_M02105 TRANSFAC + 45408713 45408724 1.0E-06 CCCCCTCTCCAG 12 Tal1_Gata1_MA0140.1 JASPAR + 45409655 45409672 9.0E-06 TGGGGATGGGGAGATAAG 18 Tal1_Gata1_MA0140.1 JASPAR + 45413143 45413160 1.0E-06 CTGGACTCAAGTGATAAG 18 V_SP1SP3_Q4_M01219 TRANSFAC - 45408997 45409007 1.0E-06 CCGCCCCCTCC 11 V_ERR1_Q3_M01841 TRANSFAC - 45407197 45407211 2.0E-06 AAGTGACCTTGAGAC 15 V_SPIB_01_M01204 TRANSFAC - 45413701 45413717 6.0E-06 GAAAACAGGAAGCCAGA 17 V_DAX1_01_M01248 TRANSFAC + 45407195 45407214 3.0E-06 GGGTCTCAAGGTCACTTGCC 20 V_ZIC3_05_M02941 TRANSFAC - 45408919 45408933 8.0E-06 AGGCACAGCAGGGCA 15 V_GATA1_09_M02254 TRANSFAC + 45409664 45409674 7.0E-06 GGAGATAAGAG 11 V_TEF_01_M01305 TRANSFAC + 45409911 45409922 7.0E-06 CACATTCCTGGC 12 V_PBX1_05_M01967 TRANSFAC + 45409832 45409845 1.0E-06 GTTGATTGACAGTT 14 V_OCAB_Q6_M02113 TRANSFAC + 45408260 45408270 4.0E-06 ATTTGCAAAGC 11 V_HNF4A_Q6_01_M02016 TRANSFAC - 45407242 45407256 8.0E-06 GGACAAAGTCCTCTA 15 V_PPARA_02_M00518 TRANSFAC - 45408886 45408904 7.0E-06 GTGGGGCATAGAGGTCTTT 19 V_TGIF1_01_M03111 TRANSFAC - 45413583 45413599 2.0E-06 AATAATGACAGCAGAAA 17 V_CTCF_02_M01259 TRANSFAC + 45407026 45407045 3.0E-06 CAGCCGCCTGCAGGGGGCGC 20 V_CTCF_01_M01200 TRANSFAC + 45407028 45407047 0.0E+00 GCCGCCTGCAGGGGGCGCCA 20 V_ELK1_01_M00007 TRANSFAC - 45413701 45413716 1.0E-06 AAAACAGGAAGCCAGA 16 V_SOX17_04_M02904 TRANSFAC + 45408724 45408740 6.0E-06 GATTACATTCATCCAGG 17 V_IRF7_01_M00453 TRANSFAC + 45407846 45407863 7.0E-06 TAGGAAAGTGACAGCGTC 18 V_SF1_Q6_01_M01132 TRANSFAC - 45407200 45407208 3.0E-06 TGACCTTGA 9 V_TFIII_Q6_M00706 TRANSFAC - 45408911 45408919 6.0E-06 AGAGGGAGG 9 V_SP4_Q5_M01273 TRANSFAC - 45409929 45409939 1.0E-06 GCCCCGCCCCC 11 V_DLX7_01_M01486 TRANSFAC + 45409018 45409034 7.0E-06 GCCCTATAATTGGACAA 17 V_CAAT_01_M00254 TRANSFAC + 45409859 45409870 1.0E-06 ACTGGCCAATCA 12 V_GATA2_01_M00076 TRANSFAC - 45407127 45407136 6.0E-06 GAAGATAGCG 10 V_TAL1_01_M01591 TRANSFAC - 45409664 45409676 8.0E-06 TTCTCTTATCTCC 13 V_TCFE2A_03_M02823 TRANSFAC + 45408278 45408294 6.0E-06 TTTAGCAGGTGCATCAT 17 V_SIRT6_01_M01797 TRANSFAC + 45409666 45409673 7.0E-06 AGATAAGA 8 V_GATA3_02_M00350 TRANSFAC + 45409664 45409673 5.0E-06 GGAGATAAGA 10 V_GATA3_02_M00350 TRANSFAC - 45413731 45413740 2.0E-06 AGAGATAAAA 10 V_T3R_Q6_M00963 TRANSFAC - 45408748 45408756 7.0E-06 CCTGTCCTT 9 V_ERR1_Q2_M00511 TRANSFAC + 45407197 45407210 5.0E-06 GTCTCAAGGTCACT 14 V_TEF1_Q6_03_M01817 TRANSFAC - 45409912 45409920 9.0E-06 CAGGAATGT 9 V_PXR_Q2_M00964 TRANSFAC + 45408754 45408765 9.0E-06 AGGGTCAGGAAA 12 V_ERR2_01_M01589 TRANSFAC + 45407200 45407211 3.0E-06 TCAAGGTCACTT 12 V_ZBTB4_04_M02929 TRANSFAC + 45409865 45409880 4.0E-06 CAATCACAGGCAGGAA 16 V_NFY_01_M00287 TRANSFAC + 45409859 45409874 5.0E-06 ACTGGCCAATCACAGG 16 V_RBPJK_01_M01112 TRANSFAC + 45406928 45406938 6.0E-06 TACGTGGGAAA 11 V_FPM315_01_M01587 TRANSFAC - 45409955 45409966 4.0E-06 GGGGGAGGAGCG 12 V_NRF2_Q4_M00821 TRANSFAC + 45407371 45407383 2.0E-06 CTGCTGTGTCAGG 13 V_MECP2_02_M01299 TRANSFAC - 45407089 45407098 9.0E-06 CCGGACTTAA 10 V_ASCL2_04_M02841 TRANSFAC - 45409301 45409316 2.0E-06 CTCTCCCCACCCCACC 16 V_PITX2_Q2_M00482 TRANSFAC - 45408238 45408248 5.0E-06 TTTAATCACAG 11 V_ESRRA_03_M02748 TRANSFAC + 45407197 45407213 4.0E-06 GTCTCAAGGTCACTTGC 17 V_ZFP281_01_M01597 TRANSFAC + 45408993 45409003 1.0E-06 TGGGGGAGGGG 11 V_ZFP281_01_M01597 TRANSFAC + 45409590 45409600 5.0E-06 AGGGGGTGGGG 11 V_ZFP281_01_M01597 TRANSFAC + 45409928 45409938 6.0E-06 TGGGGGCGGGG 11 V_TITF1_Q3_M00432 TRANSFAC + 45406963 45406972 3.0E-06 TCTCAAGTGT 10 V_IRF1_Q6_01_M01881 TRANSFAC + 45413570 45413583 0.0E+00 TATTTTCATTTTTT 14 V_LXRA_RXRA_Q3_M00647 TRANSFAC + 45407199 45407213 3.0E-06 CTCAAGGTCACTTGC 15 V_ZFP281_04_M02831 TRANSFAC - 45408871 45408885 6.0E-06 TGACCACCCCCCACA 15 V_ZFP281_04_M02831 TRANSFAC - 45409588 45409602 9.0E-06 CCCCCCACCCCCTCC 15 V_GATA2_03_M00349 TRANSFAC - 45413731 45413740 3.0E-06 AGAGATAAAA 10 V_SRF_06_M02916 TRANSFAC + 45406931 45406947 1.0E-06 GTGGGAAAAAAAACGAT 17 V_SRF_06_M02916 TRANSFAC - 45413573 45413589 6.0E-06 GCAGAAAAAAAATGAAA 17 V_EWSR1FLI1_01_M02252 TRANSFAC - 45413701 45413718 9.0E-06 GGAAAACAGGAAGCCAGA 18 V_ERR1_Q2_01_M02093 TRANSFAC + 45407201 45407211 3.0E-06 CAAGGTCACTT 11 V_COREBINDINGFACTOR_Q6_M00722 TRANSFAC - 45408138 45408145 1.0E-05 TGTGGTTT 8 V_DR3_Q4_M00966 TRANSFAC + 45408886 45408906 2.0E-06 AAAGACCTCTATGCCCCACCT 21 V_SOX15_04_M02903 TRANSFAC - 45408173 45408187 5.0E-06 TGAAATGAGATTCCA 15 V_SP1_Q2_01_M00933 TRANSFAC - 45409929 45409938 4.0E-06 CCCCGCCCCC 10 V_NFYA_Q5_M02106 TRANSFAC + 45409861 45409874 2.0E-06 TGGCCAATCACAGG 14 V_SP1_Q4_01_M00932 TRANSFAC + 45409928 45409940 2.0E-06 TGGGGGCGGGGCT 13 V_SREBP1_Q5_M01173 TRANSFAC - 45409775 45409789 5.0E-06 GGCCTCACCCCAGGT 15 V_BRF1_01_M01747 TRANSFAC - 45409605 45409617 4.0E-06 GGGTTCAAATTCC 13 V_TCF3_05_M02920 TRANSFAC - 45413576 45413590 2.0E-06 AGCAGAAAAAAAATG 15 V_EVI1_03_M00080 TRANSFAC + 45409666 45409676 6.0E-06 AGATAAGAGAA 11 V_GATA1_06_M00347 TRANSFAC - 45413731 45413740 8.0E-06 AGAGATAAAA 10

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