Search TFs or Genes

Construction and Validation

Optimal Promoter Size

Download

Citation and Contact

IDE Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 3416 insulin-degrading enzyme chr10 - 94333352 - 94338852 94333852 Transcription Factor Binding Sites   Download all TFBS in the IDE promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints MESP1_bHLH_DBD_dimeric_10_1 SELEX - 94334200 94334209 7.0E-06 AACACCTGCA 10 SOX10_HMG_full_dimeric_16_1 SELEX + 94332881 94332896 4.0E-06 AAAAGTATTCAGCGTT 16 ZNF306_C2H2_full_monomeric_14_1 SELEX - 94331458 94331471 2.0E-06 TGGTCTAACCTCTT 14 SOX9_HMG_full_dimeric_16_1 SELEX + 94332881 94332896 1.0E-05 AAAAGTATTCAGCGTT 16 SOX9_HMG_full_dimeric_16_1 SELEX + 94335798 94335813 9.0E-06 AACAATTTTGAGAGTC 16 En1_MA0027.1 JASPAR - 94334530 94334540 6.0E-06 TAGTAGTATTC 11 SRY_HMG_DBD_dimeric_13_2 SELEX - 94332879 94332891 1.0E-05 TGAATACTTTTTA 13 PDX1_homeodomain_DBD_dimeric_18_1 SELEX + 94335844 94335861 9.0E-06 TTCATTAGTCATCATGAC 18 PDX1_homeodomain_DBD_dimeric_18_1 SELEX - 94335844 94335861 8.0E-06 GTCATGATGACTAATGAA 18 FOXL1_forkhead_full_dimeric_13_1 SELEX + 94334567 94334579 3.0E-06 TTTAAACAAAGAA 13 FOXL1_forkhead_full_dimeric_13_1 SELEX - 94336031 94336043 8.0E-06 ATTCAACAAATAT 13 SOX8_HMG_DBD_dimeric_16_1 SELEX + 94332881 94332896 3.0E-06 AAAAGTATTCAGCGTT 16 SOX8_HMG_DBD_dimeric_16_1 SELEX + 94335798 94335813 3.0E-06 AACAATTTTGAGAGTC 16 ZNF435_C2H2_full_dimeric_18_1 SELEX - 94332816 94332833 3.0E-06 AACGTTATTTGAACCCCT 18 SRY_HMG_DBD_dimeric_16_1 SELEX - 94335798 94335813 9.0E-06 GACTCTCAAAATTGTT 16 HINFP1_C2H2_full_dimeric_20_1 SELEX - 94334254 94334273 1.0E-05 GCGGGCCGCGCGCCGGCCGC 20 NFIL3_MA0025.1 JASPAR - 94331423 94331433 1.0E-06 TTATGTAAGAT 11 NFIL3_MA0025.1 JASPAR - 94335275 94335285 6.0E-06 TTATGTAAGCA 11 ISL2_homeodomain_DBD_monomeric_8_1 SELEX - 94333591 94333598 1.0E-05 GCACTTAA 8 NKX3-2_homeodomain_DBD_monomeric_9_1 SELEX - 94333591 94333599 7.0E-06 AGCACTTAA 9 FOXD2_forkhead_DBD_dimeric_14_1 SELEX + 94336026 94336039 3.0E-06 GACAAATATTTGTT 14 FOXD2_forkhead_DBD_dimeric_14_1 SELEX - 94336026 94336039 2.0E-06 AACAAATATTTGTC 14 HMX3_homeodomain_DBD_monomeric_11_1 SELEX - 94333589 94333599 6.0E-06 AGCACTTAAAG 11 FOXD3_forkhead_DBD_dimeric_14_1 SELEX + 94336026 94336039 6.0E-06 GACAAATATTTGTT 14 FOXD3_forkhead_DBD_dimeric_14_1 SELEX - 94336026 94336039 8.0E-06 AACAAATATTTGTC 14 TCF4_bHLH_full_dimeric_10_1 SELEX - 94334200 94334209 5.0E-06 AACACCTGCA 10 HNF1A_homeodomain_full_dimeric_15_1 SELEX + 94332796 94332810 1.0E-06 TATTACTGATTAAAA 15 Gfi_MA0038.1 JASPAR - 94335997 94336006 2.0E-06 CAAATCACAG 10 SOX14_HMG_DBD_dimeric_13_1 SELEX + 94334989 94335001 5.0E-06 TCAATCACCTTGA 13 SOX18_HMG_full_dimeric_15_1 SELEX + 94334618 94334632 7.0E-06 AACAACTTAATAGTT 15 NFATC1_NFAT_full_dimeric_20_1 SELEX - 94331727 94331746 8.0E-06 TGAGGAAAATACAGGTCCAA 20 SOX7_HMG_full_dimeric_16_1 SELEX + 94335798 94335813 4.0E-06 AACAATTTTGAGAGTC 16 MAFK_bZIP_DBD_dimeric_21_1 SELEX + 94333592 94333612 2.0E-06 TAAGTGCTGAATCACCACTTT 21 MAFK_bZIP_DBD_dimeric_21_1 SELEX - 94333592 94333612 2.0E-06 AAAGTGGTGATTCAGCACTTA 21 HNF1B_homeodomain_full_dimeric_13_1 SELEX - 94332797 94332809 3.0E-06 TTTAATCAGTAAT 13 NKX2-3_homeodomain_full_monomeric_10_1 SELEX - 94333590 94333599 4.0E-06 AGCACTTAAA 10 MAFG_bZIP_full_dimeric_21_1 SELEX + 94333592 94333612 2.0E-06 TAAGTGCTGAATCACCACTTT 21 MAFG_bZIP_full_dimeric_21_1 SELEX - 94333592 94333612 3.0E-06 AAAGTGGTGATTCAGCACTTA 21 SPDEF_ETS_full_putative-multimer_16_1 SELEX + 94332875 94332890 1.0E-06 GTAGTAAAAAGTATTC 16 SOX21_HMG_DBD_dimeric_16_1 SELEX + 94335798 94335813 4.0E-06 AACAATTTTGAGAGTC 16 TEAD1_TEA_full_dimeric_17_1 SELEX + 94332742 94332758 1.0E-05 ACATACTTTACATAGAG 17 FOXO3_forkhead_full_putatively-multimeric_11_1 SELEX + 94333674 94333684 1.0E-05 CTTACCCACAC 11 ETS1_ETS_full_dimeric_18_1 SELEX - 94333800 94333817 9.0E-06 GCAGGAAGCGTTTGCGGT 18 SRY_HMG_DBD_dimeric_13_1 SELEX + 94334989 94335001 6.0E-06 TCAATCACCTTGA 13 ZNF410_C2H2_DBD_monomeric_17_1 SELEX + 94334644 94334660 7.0E-06 AACTTTCCATAATACCT 17 HNF1B_homeodomain_full_dimeric_15_1 SELEX + 94332796 94332810 2.0E-06 TATTACTGATTAAAA 15 Sox3_HMG_DBD_dimeric_17_1 SELEX + 94334617 94334633 9.0E-06 GAACAACTTAATAGTTG 17 NRF1_NRF_full_dimeric_12_1 SELEX + 94333844 94333855 4.0E-06 TGCGCATGCTCT 12 NFE2L2_MA0150.1 JASPAR - 94333596 94333606 3.0E-06 GTGATTCAGCA 11 Irx3_homeodomain_DBD_dimeric_12_1 SELEX + 94335278 94335289 1.0E-06 TTACATAAAAAT 12 HNF1A_MA0046.1 JASPAR + 94334559 94334572 1.0E-06 GGTTACTTTTTAAA 14 TCF3_bHLH_DBD_dimeric_10_1 SELEX - 94334200 94334209 3.0E-06 AACACCTGCA 10 HMX1_homeodomain_DBD_monomeric_11_1 SELEX - 94333589 94333599 1.0E-05 AGCACTTAAAG 11 Zfx_MA0146.1 JASPAR + 94333964 94333977 8.0E-06 ACAGCCGAGGCCTG 14 V_DMRT4_01_M01149 TRANSFAC + 94335793 94335805 0.0E+00 AAAGTAACAATTT 13 V_FOXP1_01_M00987 TRANSFAC - 94334894 94334913 7.0E-06 TAATTTTTACCTGTTTTCAT 20 V_HSF2_01_M00147 TRANSFAC + 94334576 94334585 5.0E-06 AGAATTTTCT 10 V_E2A_Q6_01_M02088 TRANSFAC - 94334198 94334210 1.0E-05 CAACACCTGCAGG 13 V_STAT5A_Q6_M01890 TRANSFAC - 94335265 94335277 3.0E-06 GCATTTCTAATAA 13 V_GAF_Q6_M01209 TRANSFAC - 94331660 94331670 4.0E-06 CATATTCTCAT 11 V_CDX2_Q5_01_M01659 TRANSFAC - 94336013 94336023 3.0E-06 GTCATAAATGA 11 V_FXR_Q3_M00631 TRANSFAC - 94334987 94335000 0.0E+00 CAAGGTGATTGACT 14 V_FXR_Q3_M00631 TRANSFAC + 94335919 94335932 2.0E-06 GAGGTTGAGTAACT 14 V_AREB6_03_M00414 TRANSFAC - 94333351 94333362 4.0E-06 CTGCACCTGGGA 12 V_ATF5_01_M01295 TRANSFAC - 94334673 94334683 1.0E-06 ATTCTTCCTTA 11 V_MAFK_03_M02776 TRANSFAC + 94335269 94335283 3.0E-06 TAGAAATGCTTACAT 15 V_SMAD3_Q6_01_M01888 TRANSFAC - 94334097 94334109 4.0E-06 AGTCAGACACACG 13 V_BCL6B_03_M02740 TRANSFAC - 94331736 94331751 2.0E-06 GCTTTTGAGGAAAATA 16 V_DMRT3_01_M01148 TRANSFAC - 94335791 94335805 0.0E+00 AAATTGTTACTTTTC 15 V_STAT3STAT3_Q3_M01220 TRANSFAC + 94333012 94333025 6.0E-06 TTGCTGGGAAATCA 14 V_MTF1_Q4_M00650 TRANSFAC - 94333740 94333753 5.0E-06 TCTGCACCCCGCAC 14 V_NKX29_01_M01352 TRANSFAC - 94334707 94334723 2.0E-06 CTAAAAGTACTTAAGCT 17 V_NKX29_01_M01352 TRANSFAC + 94334708 94334724 8.0E-06 GCTTAAGTACTTTTAGG 17 V_BCL6_01_M01183 TRANSFAC - 94335788 94335803 9.0E-06 ATTGTTACTTTTCTTT 16 V_HP1SITEFACTOR_Q6_M00725 TRANSFAC - 94329081 94329092 6.0E-06 AAATATCACCAG 12 V_MAFB_05_M02775 TRANSFAC + 94335270 94335286 3.0E-06 AGAAATGCTTACATAAA 17 V_ETS_B_M00340 TRANSFAC - 94333805 94333818 3.0E-06 AGCAGGAAGCGTTT 14 V_FOXJ2_02_M00423 TRANSFAC + 94334621 94334634 2.0E-06 AACTTAATAGTTGT 14 V_GABP_B_M00341 TRANSFAC - 94333502 94333513 5.0E-06 CCCGGAAGAGCG 12 V_OCT1_Q5_01_M00930 TRANSFAC + 94332745 94332755 8.0E-06 TACTTTACATA 11 V_CEBP_C_M00201 TRANSFAC + 94331508 94331525 5.0E-06 TGTGTTTGCAAATACATA 18 V_SOX11_04_M02899 TRANSFAC - 94335793 94335806 1.0E-06 AAAATTGTTACTTT 14 V_AP2_Q6_01_M00915 TRANSFAC + 94333541 94333553 2.0E-06 CGGGCCCCAGGCC 13 V_FOXJ1_03_M02750 TRANSFAC + 94334565 94334580 9.0E-06 TTTTTAAACAAAGAAT 16 V_HFH4_01_M00742 TRANSFAC - 94334569 94334581 7.0E-06 AATTCTTTGTTTA 13 V_HNF4A_04_M02764 TRANSFAC - 94335964 94335980 1.0E-05 GTCCTGGGTTCAAATTA 17 V_MYBL1_04_M02884 TRANSFAC - 94333004 94333018 8.0E-06 CCAGCAACTGCCGAG 15 V_CDX_Q5_M00991 TRANSFAC - 94334633 94334650 7.0E-06 GAAAGTTAGATTCATAAC 18 V_CEBPB_01_M00109 TRANSFAC - 94335877 94335890 7.0E-06 AGGTGAGGAAATAT 14 V_ETS_Q4_M00771 TRANSFAC + 94333805 94333816 1.0E-05 AAACGCTTCCTG 12 RXRA_VDR_MA0074.1 JASPAR + 94329038 94329052 1.0E-06 GGGTCAAGAAGTTTG 15 V_SOX13_03_M02797 TRANSFAC + 94335793 94335808 5.0E-06 AAAGTAACAATTTTGA 16 V_ZNF219_01_M01122 TRANSFAC + 94333387 94333398 1.0E-05 CGCCCCCCGCAC 12 V_SOX7_03_M02807 TRANSFAC + 94334564 94334585 1.0E-06 CTTTTTAAACAAAGAATTTTCT 22 V_DBP_Q6_01_M01872 TRANSFAC - 94331426 94331433 5.0E-06 TTATGTAA 8 V_DBP_Q6_01_M01872 TRANSFAC - 94335278 94335285 5.0E-06 TTATGTAA 8 V_BEL1_B_M00312 TRANSFAC + 94335271 94335298 1.0E-06 GAAATGCTTACATAAAAATGCTTCCAGA 28 V_GFI1_01_M00250 TRANSFAC - 94335989 94336012 6.0E-06 GATGAGCAAATCACAGGTTTTGGA 24 V_HNF1_Q6_M00790 TRANSFAC + 94334558 94334575 1.0E-06 TGGTTACTTTTTAAACAA 18 V_HNF1_Q6_M00790 TRANSFAC + 94334722 94334739 3.0E-06 AGGTTTCTGATTGACAGA 18 V_TEF_Q6_M00672 TRANSFAC + 94335274 94335285 1.0E-06 ATGCTTACATAA 12 V_SOX8_04_M02912 TRANSFAC - 94334630 94334643 4.0E-06 AGATTCATAACAAC 14 V_HIC1_06_M02867 TRANSFAC + 94331476 94331491 3.0E-06 ATGAATGCCCAAATAC 16 V_SOX1_04_M02906 TRANSFAC + 94334625 94334639 4.0E-06 TAATAGTTGTTATGA 15 Hand1_Tcfe2a_MA0092.1 JASPAR - 94331548 94331557 4.0E-06 TATCTGGCAT 10 Hand1_Tcfe2a_MA0092.1 JASPAR + 94335821 94335830 3.0E-06 TGTCTGGCAT 10 V_HSF1_01_M00146 TRANSFAC + 94334576 94334585 7.0E-06 AGAATTTTCT 10 V_HOXA3_07_M02869 TRANSFAC - 94334622 94334635 9.0E-06 AACAACTATTAAGT 14 V_RXRA_04_M02895 TRANSFAC + 94329041 94329056 1.0E-06 TCAAGAAGTTTGAACT 16 V_HNF3_Q6_M00791 TRANSFAC - 94336030 94336042 8.0E-06 TTCAACAAATATT 13 V_HOXC11_01_M01329 TRANSFAC - 94336012 94336027 2.0E-06 TCAAGTCATAAATGAG 16 V_SOX_Q6_M01014 TRANSFAC - 94334567 94334579 3.0E-06 TTCTTTGTTTAAA 13 V_HNF1_Q6_01_M01011 TRANSFAC + 94334556 94334576 4.0E-06 AGTGGTTACTTTTTAAACAAA 21 V_HNF1_Q6_01_M01011 TRANSFAC - 94334556 94334576 1.0E-06 TTTGTTTAAAAAGTAACCACT 21 V_HNF1_Q6_01_M01011 TRANSFAC - 94334720 94334740 8.0E-06 GTCTGTCAATCAGAAACCTAA 21 V_MEF2_03_M00232 TRANSFAC + 94329054 94329075 8.0E-06 ACTTGATCTTGAAATAGCACAG 22 V_HOXD11_01_M01434 TRANSFAC - 94336011 94336027 9.0E-06 TCAAGTCATAAATGAGA 17 V_JUNDM2_04_M02876 TRANSFAC + 94335843 94335858 8.0E-06 CTTCATTAGTCATCAT 16 V_ERR1_Q3_M01841 TRANSFAC + 94334990 94335004 8.0E-06 CAATCACCTTGAAGC 15 V_HNF4_DR1_Q3_M00764 TRANSFAC - 94332716 94332728 9.0E-06 GGAACTTTGACTT 13 V_STAT4_Q5_M02117 TRANSFAC + 94335265 94335274 6.0E-06 TTATTAGAAA 10 V_ARID3A_04_M02735 TRANSFAC - 94332796 94332812 6.0E-06 GGTTTTAATCAGTAATA 17 V_SMAD4_Q6_M00733 TRANSFAC + 94332731 94332745 9.0E-06 GGAAGGCAGACACAT 15 V_HOXA11_01_M01378 TRANSFAC - 94336012 94336027 4.0E-06 TCAAGTCATAAATGAG 16 V_POU6F1_01_M00465 TRANSFAC + 94334904 94334914 6.0E-06 GTAAAAATTAT 11 V_LMO2COM_01_M00277 TRANSFAC + 94334199 94334210 4.0E-06 CTGCAGGTGTTG 12 V_STAT3_03_M01595 TRANSFAC + 94333011 94333026 2.0E-06 GTTGCTGGGAAATCAA 16 V_IK3_01_M00088 TRANSFAC + 94334524 94334536 1.0E-06 TACTAGGAATACT 13 V_SOX11_03_M02795 TRANSFAC + 94334566 94334582 0.0E+00 TTTTAAACAAAGAATTT 17 V_NKX23_01_M01457 TRANSFAC + 94334708 94334723 4.0E-06 GCTTAAGTACTTTTAG 16 V_NKX23_01_M01457 TRANSFAC - 94334708 94334723 2.0E-06 CTAAAAGTACTTAAGC 16 V_NKX32_02_M01482 TRANSFAC - 94333587 94333603 2.0E-06 ATTCAGCACTTAAAGCC 17 V_GCNF_01_M00526 TRANSFAC - 94329049 94329066 1.0E-06 TTCAAGATCAAGTTCAAA 18 V_ZFP105_04_M02931 TRANSFAC + 94329036 94329052 2.0E-06 CTGGGTCAAGAAGTTTG 17 V_SOX15_03_M02799 TRANSFAC + 94334566 94334582 8.0E-06 TTTTAAACAAAGAATTT 17 V_ZIC2_05_M02940 TRANSFAC - 94329029 94329043 4.0E-06 TGACCCAGCATGTAA 15 V_HAND1E47_01_M00222 TRANSFAC + 94335816 94335831 6.0E-06 CTCTGTGTCTGGCATT 16 V_TAL1_01_M01591 TRANSFAC - 94335894 94335906 1.0E-06 CTTCCTCATCTCT 13 V_HNF1_01_M00132 TRANSFAC + 94332796 94332810 9.0E-06 TATTACTGATTAAAA 15 V_HNF1_01_M00132 TRANSFAC + 94334559 94334573 1.0E-06 GGTTACTTTTTAAAC 15 V_NKX3A_02_M01383 TRANSFAC - 94334707 94334723 2.0E-06 CTAAAAGTACTTAAGCT 17 V_NKX3A_02_M01383 TRANSFAC + 94334708 94334724 8.0E-06 GCTTAAGTACTTTTAGG 17 V_CPHX_01_M01478 TRANSFAC - 94335998 94336011 6.0E-06 ATGAGCAAATCACA 14 V_TCF7_04_M02921 TRANSFAC + 94335263 94335277 2.0E-06 ACTTATTAGAAATGC 15 V_DMRT7_01_M01151 TRANSFAC - 94334906 94334919 9.0E-06 TTGCCATAATTTTT 14 V_DMRT7_01_M01151 TRANSFAC - 94335789 94335802 4.0E-06 TTGTTACTTTTCTT 14 V_DMRT7_01_M01151 TRANSFAC + 94335794 94335807 4.0E-06 AAGTAACAATTTTG 14 V_ZFP206_01_M01742 TRANSFAC + 94333844 94333854 3.0E-06 TGCGCATGCTC 11 V_NKX22_01_M00485 TRANSFAC + 94334710 94334719 1.0E-06 TTAAGTACTT 10 V_STAT1STAT1_Q3_M01212 TRANSFAC - 94333011 94333023 6.0E-06 ATTTCCCAGCAAC 13 V_NFAT2_02_M01749 TRANSFAC - 94332724 94332734 6.0E-06 TTCCAAGGAAC 11 V_PLZF_02_M01075 TRANSFAC + 94334557 94334585 8.0E-06 GTGGTTACTTTTTAAACAAAGAATTTTCT 29 V_ETS1_B_M00339 TRANSFAC - 94333803 94333817 3.0E-06 GCAGGAAGCGTTTGC 15 V_FOXJ2_01_M00422 TRANSFAC - 94336027 94336044 2.0E-06 CATTCAACAAATATTTGT 18 V_SMAD3_Q6_M00701 TRANSFAC - 94332734 94332742 1.0E-05 TGTCTGCCT 9 V_SMAD3_Q6_M00701 TRANSFAC + 94334101 94334109 6.0E-06 TGTCTGACT 9 V_IRF1_01_M00062 TRANSFAC + 94335791 94335803 7.0E-06 GAAAAGTAACAAT 13 V_RFX3_04_M02788 TRANSFAC - 94334623 94334645 8.0E-06 TTAGATTCATAACAACTATTAAG 23 V_HOXC10_01_M01361 TRANSFAC - 94336012 94336027 5.0E-06 TCAAGTCATAAATGAG 16 V_NFE2L2_01_M02263 TRANSFAC - 94333596 94333606 3.0E-06 GTGATTCAGCA 11 V_HOXA10_01_M01464 TRANSFAC + 94332872 94332887 6.0E-06 TTCGTAGTAAAAAGTA 16 V_SOX5_07_M02909 TRANSFAC - 94335793 94335809 3.0E-06 CTCAAAATTGTTACTTT 17 V_GFI1_Q6_01_M02010 TRANSFAC + 94335997 94336006 2.0E-06 CTGTGATTTG 10 V_TCF11MAFG_01_M00284 TRANSFAC + 94336014 94336035 1.0E-06 CATTTATGACTTGACAAATATT 22 V_HNF1A_01_M02162 TRANSFAC + 94334559 94334572 1.0E-06 GGTTACTTTTTAAA 14 V_COUP_DR1_Q6_M00765 TRANSFAC - 94332716 94332728 5.0E-06 GGAACTTTGACTT 13 V_ATATA_B_M00311 TRANSFAC - 94334708 94334717 5.0E-06 GTACTTAAGC 10 V_DMRT1_01_M01146 TRANSFAC - 94335788 94335802 9.0E-06 TTGTTACTTTTCTTT 15 V_DMRT1_01_M01146 TRANSFAC + 94335794 94335808 8.0E-06 AAGTAACAATTTTGA 15 V_VDRRXR_01_M01202 TRANSFAC + 94329038 94329052 1.0E-06 GGGTCAAGAAGTTTG 15 V_SOX9_Q4_M01284 TRANSFAC + 94334570 94334580 7.0E-06 AAACAAAGAAT 11 V_DMRT5_01_M01150 TRANSFAC + 94334556 94334570 7.0E-06 AGTGGTTACTTTTTA 15 V_OCT4_01_M01125 TRANSFAC - 94335276 94335290 1.0E-05 CATTTTTATGTAAGC 15

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.