Search TFs or Genes

Construction and Validation

Optimal Promoter Size

Download

Citation and Contact

HMGCS1 Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 3157 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) chr5 - 43313114 - 43318614 43313614 Transcription Factor Binding Sites   Download all TFBS in the HMGCS1 promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints Foxa2_MA0047.2 JASPAR - 43314119 43314130 9.0E-06 TATTTACACATA 12 SOX4_HMG_DBD_dimeric_16_1 SELEX - 43314025 43314040 7.0E-06 AATCAAGTACAGTATT 16 Myc_MA0147.1 JASPAR + 43315481 43315490 7.0E-06 CGCACGTGGT 10 NFIA_NFI_full_dimeric_15_1 SELEX + 43309878 43309892 6.0E-06 ATGGCAAGTAGCCAG 15 KLF16_C2H2_DBD_monomeric_11_1 SELEX + 43312985 43312995 7.0E-06 GACACACCCCC 11 POU3F3_POU_DBD_monomeric_12_1 SELEX - 43309999 43310010 6.0E-06 TTGCATAAATCT 12 POU3F2_POU_DBD_monomeric_13_1 SELEX - 43309999 43310011 7.0E-06 ATTGCATAAATCT 13 POU3F4_POU_DBD_monomeric_11_1 SELEX - 43309999 43310009 5.0E-06 TGCATAAATCT 11 SOX8_HMG_full_dimeric_17_1 SELEX - 43314024 43314040 9.0E-06 AATCAAGTACAGTATTT 17 EWSR1-FLI1_MA0149.1 JASPAR - 43312944 43312961 5.0E-06 GGAAAGAAGGGAAGTGGG 18 NFIX_NFI_full_dimeric_15_2 SELEX + 43309878 43309892 7.0E-06 ATGGCAAGTAGCCAG 15 NFIX_NFI_full_dimeric_15_2 SELEX - 43309878 43309892 1.0E-06 CTGGCTACTTGCCAT 15 NFYA_MA0060.1 JASPAR - 43315508 43315523 7.0E-06 CCTAGCCAATAAGGGA 16 E2F7_E2F_DBD_dimeric_14_1 SELEX - 43315573 43315586 2.0E-06 TTTTCCCGCCATCA 14 RORA_nuclearreceptor_DBD_dimeric_19_1 SELEX + 43312970 43312988 9.0E-06 TATATGTGGCAGCAGGACA 19 RFX2_RFX_DBD_dimeric_15_1 SELEX + 43313980 43313994 7.0E-06 GGTTGCCTAGCAACC 15 RFX2_RFX_DBD_dimeric_15_1 SELEX - 43313980 43313994 0.0E+00 GGTTGCTAGGCAACC 15 Esrra_nuclearreceptor_DBD_dimeric_17_1 SELEX - 43313024 43313040 1.0E-05 AAGGATGGGCAAGATCC 17 FOXJ3_forkhead_DBD_dimeric_14_1 SELEX + 43314946 43314959 8.0E-06 CTAGATAGTAAACA 14 XBP1_bZIP_DBD_dimeric_14_1 SELEX + 43314439 43314452 6.0E-06 AAGGCCACGTAATT 14 RFX3_RFX_DBD_dimeric_15_1 SELEX - 43313980 43313994 0.0E+00 GGTTGCTAGGCAACC 15 CTCF_C2H2_full_monomeric_17_1 SELEX + 43313190 43313206 3.0E-06 AACGCCCTCTCGCGTTC 17 PBX1_MA0070.1 JASPAR + 43313662 43313673 7.0E-06 CTACCAATCAAA 12 RFX4_RFX_DBD_dimeric_15_1 SELEX - 43313980 43313994 0.0E+00 GGTTGCTAGGCAACC 15 Foxd3_MA0041.1 JASPAR - 43314204 43314215 5.0E-06 TTTTGTTTGTTC 12 EN1_homeodomain_full_dimeric_14_1 SELEX + 43314149 43314162 9.0E-06 TAAATACTCAAATA 14 POU3F1_POU_DBD_monomeric_12_2 SELEX - 43309999 43310010 1.0E-05 TTGCATAAATCT 12 NFIB_NFI_full_dimeric_15_1 SELEX + 43309878 43309892 5.0E-06 ATGGCAAGTAGCCAG 15 HNF4A_MA0114.1 JASPAR + 43313319 43313331 5.0E-06 CGGGCAAAGTCCA 13 HMX2_homeodomain_DBD_monomeric_11_1 SELEX + 43313664 43313674 8.0E-06 ACCAATCAAAA 11 FOXB1_forkhead_DBD_monomeric_11_1 SELEX + 43314121 43314131 7.0E-06 TGTGTAAATAG 11 HNF1A_MA0046.1 JASPAR + 43309869 43309882 9.0E-06 AGTTAATGAATGGC 14 FOXJ2_forkhead_DBD_dimeric_14_1 SELEX + 43314124 43314137 6.0E-06 GTAAATAGTCTAAA 14 FOXJ2_forkhead_DBD_dimeric_14_1 SELEX + 43314197 43314210 8.0E-06 GAAAACAGAACAAA 14 V_NFAT_Q4_01_M00935 TRANSFAC - 43315878 43315887 5.0E-06 TTGGAAAATC 10 V_FOXP1_01_M00987 TRANSFAC - 43314194 43314213 1.0E-06 TTGTTTGTTCTGTTTTCTTT 20 V_MEIS1BHOXA9_02_M00421 TRANSFAC + 43315756 43315769 4.0E-06 TGACATATTAATTC 14 V_HNF3B_01_M00131 TRANSFAC - 43314194 43314208 1.0E-05 TGTTCTGTTTTCTTT 15 V_ZFP187_03_M02830 TRANSFAC + 43315551 43315564 5.0E-06 CGATGGACTAATTT 14 V_POU3F3_01_M03090 TRANSFAC - 43314168 43314184 4.0E-06 TAGTTTTGAATAAAGGA 17 V_AR_02_M00953 TRANSFAC + 43310023 43310049 2.0E-06 CTGGAGTTTACTCAGTGTTCTGAATAC 27 V_E2F4_Q6_M02090 TRANSFAC + 43315578 43315587 3.0E-06 GCGGGAAAAA 10 V_OSF2_Q6_M00731 TRANSFAC + 43309900 43309907 1.0E-05 ACCACAAA 8 V_GATA2_02_M00348 TRANSFAC + 43309973 43309982 3.0E-06 AATGATAAGA 10 V_NFY_Q6_M00185 TRANSFAC - 43315511 43315521 6.0E-06 TAGCCAATAAG 11 V_CEBP_Q3_M00770 TRANSFAC - 43309780 43309791 7.0E-06 GACTTTGGCAAT 12 V_NF1A_Q6_M02103 TRANSFAC - 43309877 43309892 1.0E-06 CTGGCTACTTGCCATT 16 V_FOXD3_01_M00130 TRANSFAC - 43314204 43314215 4.0E-06 TTTTGTTTGTTC 12 V_BCL6_01_M01183 TRANSFAC - 43314013 43314028 8.0E-06 TATTTCAGAAATCTTT 16 V_BCL6_01_M01183 TRANSFAC - 43314229 43314244 1.0E-06 TTAGTTAGAAAGCTTT 16 V_ERR3_Q2_01_M02094 TRANSFAC + 43313372 43313384 7.0E-06 AGTCAAGGACACC 13 V_LRH1_Q5_01_M02098 TRANSFAC + 43312595 43312605 6.0E-06 GGTCAAGGCCA 11 V_HOXA3_01_M00395 TRANSFAC + 43314446 43314454 4.0E-06 CGTAATTGT 9 V_MAFB_03_M02879 TRANSFAC - 43309999 43310013 1.0E-06 CCATTGCATAAATCT 15 V_OCT1_Q5_01_M00930 TRANSFAC - 43314934 43314944 8.0E-06 TACTTTACATA 11 V_ZTA_Q2_M00711 TRANSFAC - 43315599 43315611 1.0E-06 TCACCCTGACTCA 13 V_OCTAMER_01_M01324 TRANSFAC - 43314168 43314184 4.0E-06 TAGTTTTGAATAAAGGA 17 V_NFAT3_Q3_M01734 TRANSFAC + 43315877 43315886 1.0E-05 TGATTTTCCA 10 V_HOXA4_01_M01370 TRANSFAC - 43309867 43309883 1.0E-05 TGCCATTCATTAACTGC 17 V_CEBP_Q2_M00190 TRANSFAC - 43310000 43310013 4.0E-06 CCATTGCATAAATC 14 V_RFX4_03_M02789 TRANSFAC + 43313982 43313996 4.0E-06 TTGCCTAGCAACCAG 15 V_IRF3_05_M02767 TRANSFAC + 43313669 43313682 2.0E-06 TCAAAAGGAAACTA 14 V_HNF3_Q6_01_M01012 TRANSFAC - 43314200 43314217 0.0E+00 ACTTTTGTTTGTTCTGTT 18 V_FOXJ1_03_M02750 TRANSFAC + 43314203 43314218 5.0E-06 AGAACAAACAAAAGTG 16 V_P50RELAP65_Q5_01_M01224 TRANSFAC + 43313700 43313711 1.0E-06 GGATTTTCCCTC 12 V_HNF4A_03_M02220 TRANSFAC + 43313319 43313331 5.0E-06 CGGGCAAAGTCCA 13 V_CMYB_Q5_M01821 TRANSFAC + 43313083 43313093 5.0E-06 CCCAACTGTCT 11 V_PU1_Q4_M01172 TRANSFAC + 43312940 43312958 9.0E-06 GCTACCCACTTCCCTTCTT 19 V_CDX_Q5_M00991 TRANSFAC + 43314135 43314152 6.0E-06 AAATACCCGATTTGTAAA 18 V_AR_03_M00956 TRANSFAC + 43310023 43310049 4.0E-06 CTGGAGTTTACTCAGTGTTCTGAATAC 27 V_BARBIE_01_M00238 TRANSFAC - 43313530 43313544 1.0E-06 CTATAAAGCTGGTGG 15 V_HNF1_C_M00206 TRANSFAC + 43309869 43309885 2.0E-06 AGTTAATGAATGGCAAG 17 V_NFY_C_M00209 TRANSFAC - 43313660 43313673 2.0E-06 TTTGATTGGTAGAA 14 V_MYC_01_M02250 TRANSFAC + 43315481 43315490 7.0E-06 CGCACGTGGT 10 V_ETS_Q4_M00771 TRANSFAC - 43313759 43313770 7.0E-06 CACCACTTCCTC 12 V_BACH1_01_M00495 TRANSFAC + 43315595 43315609 7.0E-06 GAAATGAGTCAGGGT 15 V_BACH1_01_M00495 TRANSFAC + 43315622 43315636 7.0E-06 GGAATGAGTCAAGGT 15 V_BACH1_01_M00495 TRANSFAC + 43315650 43315664 4.0E-06 AGAATGAGTCAAGGT 15 V_BACH1_01_M00495 TRANSFAC + 43315667 43315681 6.0E-06 AGAATGAGTCAGGTT 15 V_HELIOSA_02_M01004 TRANSFAC - 43315879 43315889 4.0E-06 TTTTGGAAAAT 11 V_TCF3_04_M02816 TRANSFAC - 43312632 43312648 7.0E-06 GATATTTCAAAGCAAGT 17 V_TCF3_04_M02816 TRANSFAC - 43315764 43315780 2.0E-06 TTCTCTTCAAAGAATTA 17 V_FREAC3_01_M00291 TRANSFAC + 43314143 43314158 6.0E-06 GATTTGTAAATACTCA 16 V_SPI1_03_M02078 TRANSFAC + 43313758 43313767 1.0E-05 CGAGGAAGTG 10 V_FOXO1_02_M00474 TRANSFAC - 43314194 43314207 9.0E-06 GTTCTGTTTTCTTT 14 V_HNF3G_Q4_M02015 TRANSFAC - 43314205 43314212 7.0E-06 TGTTTGTT 8 V_HNF4_01_B_M00411 TRANSFAC + 43313318 43313332 5.0E-06 CCGGGCAAAGTCCAC 15 V_NKX31_02_M02782 TRANSFAC + 43309740 43309756 5.0E-06 CTGTGCTACTTAAGGAT 17 V_RFX1_01_M00280 TRANSFAC + 43313979 43313995 0.0E+00 AGGTTGCCTAGCAACCA 17 V_RFX1_01_M00280 TRANSFAC - 43313979 43313995 0.0E+00 TGGTTGCTAGGCAACCT 17 V_CEBPD_Q6_M00621 TRANSFAC - 43315589 43315600 4.0E-06 CATTTCATAACC 12 V_P53_03_M01651 TRANSFAC + 43310254 43310273 3.0E-06 AGACTTGCTCAAACCTGTAC 20 V_P53_03_M01651 TRANSFAC - 43310254 43310273 4.0E-06 GTACAGGTTTGAGCAAGTCT 20 V_HNF3_Q6_M00791 TRANSFAC + 43314202 43314214 2.0E-06 CAGAACAAACAAA 13 V_HNF3ALPHA_Q6_M00724 TRANSFAC - 43314202 43314212 3.0E-06 TGTTTGTTCTG 11 V_NKX52_01_M01315 TRANSFAC + 43309863 43309879 1.0E-06 AGAAGCAGTTAATGAAT 17 V_RFXDC2_03_M02790 TRANSFAC + 43313982 43313996 2.0E-06 TTGCCTAGCAACCAG 15 V_PBX1_01_M00096 TRANSFAC + 43313664 43313672 1.0E-05 ACCAATCAA 9 V_OCT1_04_M00138 TRANSFAC + 43314146 43314168 6.0E-06 TTGTAAATACTCAAATATTGTCT 23 V_GR_01_M00955 TRANSFAC + 43310023 43310049 5.0E-06 CTGGAGTTTACTCAGTGTTCTGAATAC 27 V_PEBP_Q6_M00984 TRANSFAC + 43309896 43309910 9.0E-06 GGTTACCACAAAGCA 15 V_TCF7_03_M02817 TRANSFAC - 43315764 43315780 3.0E-06 TTCTCTTCAAAGAATTA 17 V_AP1_C_M00199 TRANSFAC + 43315598 43315606 3.0E-06 ATGAGTCAG 9 V_AP1_C_M00199 TRANSFAC + 43315670 43315678 3.0E-06 ATGAGTCAG 9 V_HNF4A_Q6_01_M02016 TRANSFAC + 43313320 43313334 2.0E-06 GGGCAAAGTCCACGC 15 V_PPARA_02_M00518 TRANSFAC - 43313181 43313199 8.0E-06 AGAGGGCGTTGAGGTCTAG 19 V_AP1_01_M00517 TRANSFAC + 43315668 43315680 8.0E-06 GAATGAGTCAGGT 13 V_ISGF4G_04_M02875 TRANSFAC + 43314196 43314209 8.0E-06 AGAAAACAGAACAA 14 V_AP1_Q2_01_M00924 TRANSFAC - 43315649 43315660 2.0E-06 TGACTCATTCTG 12 V_AP1_Q2_01_M00924 TRANSFAC - 43315666 43315677 3.0E-06 TGACTCATTCTC 12 V_HNF4A_02_M02868 TRANSFAC + 43313320 43313335 8.0E-06 GGGCAAAGTCCACGCC 16 V_SOX17_04_M02904 TRANSFAC - 43314926 43314942 7.0E-06 CTTTACATACATATGAA 17 V_CAAT_01_M00254 TRANSFAC - 43315512 43315523 5.0E-06 CCTAGCCAATAA 12 V_GFI1_Q6_M01067 TRANSFAC + 43312886 43312898 2.0E-06 CTAAATCACGGTT 13 V_ISX_01_M01331 TRANSFAC - 43313865 43313880 9.0E-06 AGTCCCAATTGGTCGG 16 V_TAL1_01_M01591 TRANSFAC + 43313088 43313100 5.0E-06 CTGTCTTCTCTCC 13 V_HNF1_01_M00132 TRANSFAC + 43309869 43309883 3.0E-06 AGTTAATGAATGGCA 15 V_FOXL1_02_M02857 TRANSFAC + 43314244 43314259 3.0E-06 AACCTAAAACAAAATG 16 V_LUN1_01_M00480 TRANSFAC - 43309462 43309478 3.0E-06 TCCCAGCTACTTGCGGG 17 V_LUN1_01_M00480 TRANSFAC + 43313353 43313369 8.0E-06 CCCCAGCTCCTTCGGGC 17 V_FOXJ3_06_M02855 TRANSFAC + 43309957 43309973 9.0E-06 AAGACTAAAACACAAGA 17 V_NKX3A_02_M01383 TRANSFAC + 43314146 43314162 5.0E-06 TTGTAAATACTCAAATA 17 V_T3R_Q6_M00963 TRANSFAC - 43313502 43313510 3.0E-06 ACTGTCCTT 9 V_DELTAEF1_01_M00073 TRANSFAC + 43314004 43314014 4.0E-06 CTTCACCTGAA 11 V_GFI1B_01_M01058 TRANSFAC + 43312887 43312898 3.0E-06 TAAATCACGGTT 12 V_HNF4_Q6_01_M01031 TRANSFAC + 43313319 43313332 2.0E-06 CGGGCAAAGTCCAC 14 V_XBP1_01_M00251 TRANSFAC - 43314438 43314454 1.0E-06 ACAATTACGTGGCCTTT 17 V_TCF7_04_M02921 TRANSFAC + 43314170 43314184 9.0E-06 CTTTATTCAAAACTA 15 V_GATA6_01_M00462 TRANSFAC + 43309973 43309982 1.0E-06 AATGATAAGA 10 V_NFY_01_M00287 TRANSFAC - 43315508 43315523 9.0E-06 CCTAGCCAATAAGGGA 16 V_ASCL2_04_M02841 TRANSFAC - 43313718 43313733 8.0E-06 TTCTCCCCGCCCTTCC 16 V_SPIC_02_M02077 TRANSFAC + 43313758 43313767 9.0E-06 CGAGGAAGTG 10 V_P53_05_M01655 TRANSFAC + 43310254 43310273 1.0E-05 AGACTTGCTCAAACCTGTAC 20 V_FOXA2_03_M02260 TRANSFAC - 43314119 43314130 9.0E-06 TATTTACACATA 12 V_P53_04_M01652 TRANSFAC - 43310254 43310273 1.0E-05 GTACAGGTTTGAGCAAGTCT 20 V_CEBPB_Q6_M01896 TRANSFAC + 43310003 43310012 7.0E-06 TTATGCAATG 10 V_BBX_03_M02739 TRANSFAC + 43315764 43315778 2.0E-06 TAATTCTTTGAAGAG 15 V_OCT1_06_M00162 TRANSFAC + 43315751 43315764 1.0E-06 CATACTGACATATT 14 V_P63_01_M01656 TRANSFAC + 43310254 43310273 8.0E-06 AGACTTGCTCAAACCTGTAC 20 V_DMRT2_01_M01147 TRANSFAC - 43315742 43315757 2.0E-06 CAGTATGTTCCATTCT 16 V_SRF_06_M02916 TRANSFAC + 43314190 43314206 8.0E-06 ACTTAAAGAAAACAGAA 17 V_E2F_01_M00024 TRANSFAC + 43315575 43315589 0.0E+00 ATGGCGGGAAAAATG 15 V_NKX11_01_M01334 TRANSFAC - 43313864 43313880 9.0E-06 AGTCCCAATTGGTCGGA 17 V_HSF2_02_M01244 TRANSFAC - 43313229 43313241 1.0E-05 GAAGATCCGAGAA 13 V_EWSR1FLI1_01_M02252 TRANSFAC - 43312944 43312961 5.0E-06 GGAAAGAAGGGAAGTGGG 18 V_FOXJ2_01_M00422 TRANSFAC + 43314200 43314217 7.0E-06 AACAGAACAAACAAAAGT 18 V_NFE2_Q6_M02104 TRANSFAC - 43309911 43309926 0.0E+00 CATGAGTCTGCAAACC 16 V_SOX18_04_M02905 TRANSFAC - 43314037 43314052 0.0E+00 AGACTGAATTCAAATC 16 V_SOX18_04_M02905 TRANSFAC + 43314318 43314333 2.0E-06 ATACTGAATTCAAGGA 16 V_HNF1A_Q5_M02013 TRANSFAC + 43309869 43309879 4.0E-06 AGTTAATGAAT 11 V_PR_02_M00957 TRANSFAC + 43310023 43310049 4.0E-06 CTGGAGTTTACTCAGTGTTCTGAATAC 27 V_PR_02_M00957 TRANSFAC + 43315853 43315879 9.0E-06 ATGTCTTGATTTAGTTGTTCTGCTTGA 27 V_HNF3B_Q6_M02014 TRANSFAC - 43314205 43314213 1.0E-05 TTGTTTGTT 9 V_RFX3_04_M02788 TRANSFAC + 43313978 43314000 2.0E-06 CAGGTTGCCTAGCAACCAGAACT 23 V_PIT1_Q6_M00802 TRANSFAC + 43314924 43314941 4.0E-06 ACTTCATATGTATGTAAA 18 V_PAX1_B_M00326 TRANSFAC - 43313177 43313194 4.0E-06 GCGTTGAGGTCTAGGTAT 18 V_CTF1_01_M01196 TRANSFAC - 43309878 43309891 6.0E-06 TGGCTACTTGCCAT 14 V_CTF1_01_M01196 TRANSFAC + 43309879 43309892 4.0E-06 TGGCAAGTAGCCAG 14 V_MEF2_01_M00006 TRANSFAC - 43309805 43309820 4.0E-06 TGTTAGAAATAAGCTT 16 V_GATA6_04_M02757 TRANSFAC + 43309970 43309986 6.0E-06 AAGAATGATAAGACTGC 17 V_ZFP128_04_M02932 TRANSFAC + 43314115 43314128 8.0E-06 TGTATATGTGTAAA 14 V_NFYA_Q5_M02106 TRANSFAC + 43313607 43313620 8.0E-06 CAGCCAATCGCGGC 14 V_P300_01_M00033 TRANSFAC + 43313484 43313497 1.0E-06 AAAGGGAGTGAGCC 14 V_EHF_07_M02849 TRANSFAC + 43315542 43315557 3.0E-06 AACTAATTCCGATGGA 16 V_HNF1A_01_M02162 TRANSFAC + 43309869 43309882 9.0E-06 AGTTAATGAATGGC 14 V_OBOX3_02_M03065 TRANSFAC - 43314459 43314475 1.0E-05 TCCGATGGATTTACTAT 17 V_TCF3_05_M02920 TRANSFAC + 43314244 43314258 1.0E-06 AACCTAAAACAAAAT 15 TLX1_NFIC_MA0119.1 JASPAR - 43309878 43309891 6.0E-06 TGGCTACTTGCCAT 14 TLX1_NFIC_MA0119.1 JASPAR + 43309879 43309892 4.0E-06 TGGCAAGTAGCCAG 14 V_MIF1_01_M00279 TRANSFAC - 43313978 43313995 0.0E+00 TGGTTGCTAGGCAACCTG 18 V_OBOX3_01_M01466 TRANSFAC - 43314459 43314475 1.0E-05 TCCGATGGATTTACTAT 17 V_NF1_Q6_M00193 TRANSFAC - 43314408 43314425 8.0E-06 ACTTGGCAGGTACCACAT 18

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.