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HMGCL Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 3155 3-hydroxymethyl-3-methylglutaryl-CoA lyase chr1 - 24151449 - 24156949 24151949 Transcription Factor Binding Sites   Download all TFBS in the HMGCL promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints FOXB1_forkhead_DBD_dimeric_18_1 SELEX - 24152502 24152519 2.0E-06 TGTGTAACTATTAATATG 18 TBX21_TBX_full_dimeric_16_1 SELEX + 24152488 24152503 8.0E-06 GGTGTGAGGAGACACA 16 FOXJ2_forkhead_DBD_dimeric_13_1 SELEX + 24152425 24152437 1.0E-06 ACAAACAAAAACA 13 KLF16_C2H2_DBD_monomeric_11_1 SELEX + 24151975 24151985 1.0E-05 GCCCCGCCCCC 11 RARA_nuclearreceptor_full_dimeric_18_1 SELEX + 24152150 24152167 8.0E-06 GTAGATCACCTGAGGTCA 18 FOXG1_forkhead_DBD_dimeric_17_1 SELEX + 24152421 24152437 8.0E-06 CCAAACAAACAAAAACA 17 ESR2_MA0258.1 JASPAR - 24151614 24151631 1.0E-06 CTGGGTCATGGAGACCTG 18 RARG_nuclearreceptor_full_dimeric_17_1 SELEX + 24152151 24152167 1.0E-05 TAGATCACCTGAGGTCA 17 Rarb_nuclearreceptor_DBD_dimeric_18_1 SELEX + 24152150 24152167 6.0E-06 GTAGATCACCTGAGGTCA 18 Tp73_p53l_DBD_dimeric_18_1 SELEX - 24156847 24156864 6.0E-06 TCCATGTTGCAACATGTG 18 LEF1_HMG_DBD_monomeric_15_1 SELEX + 24152433 24152447 5.0E-06 AAACATGAAAAGAAA 15 FOXD3_forkhead_DBD_dimeric_14_1 SELEX + 24152504 24152517 5.0E-06 TATTAATAGTTACA 14 RARG_nuclearreceptor_DBD_dimeric_17_2 SELEX + 24152151 24152167 7.0E-06 TAGATCACCTGAGGTCA 17 E2F8_E2F_DBD_dimeric_12_1 SELEX - 24151683 24151694 3.0E-06 TTTCCCCTCAAA 12 ESR1_MA0112.2 JASPAR + 24151610 24151629 0.0E+00 GTCCCAGGTCTCCATGACCC 20 SP1_MA0079.2 JASPAR + 24151976 24151985 7.0E-06 CCCCGCCCCC 10 FOXB1_forkhead_DBD_putative-multimer_14_1 SELEX - 24152522 24152535 3.0E-06 AAATGACACAACTG 14 Lhx3_MA0135.1 JASPAR + 24152445 24152457 9.0E-06 AAATTAACCAAAT 13 RARG_nuclearreceptor_DBD_dimeric_17_1 SELEX + 24152151 24152167 4.0E-06 TAGATCACCTGAGGTCA 17 Foxd3_MA0041.1 JASPAR - 24152423 24152434 1.0E-06 TTTTGTTTGTTT 12 MGA_TBX_DBD_dimeric_18_1 SELEX - 24152487 24152504 7.0E-06 ATGTGTCTCCTCACACCT 18 FOXC2_forkhead_DBD_dimeric_14_1 SELEX + 24152504 24152517 6.0E-06 TATTAATAGTTACA 14 Tp53_p53l_DBD_dimeric_17_1 SELEX + 24156837 24156853 2.0E-06 ACAATTCTGACACATGT 17 RUNX1_MA0002.2 JASPAR + 24152457 24152467 8.0E-06 TTCTGTGGCTT 11 FOXC1_forkhead_DBD_dimeric_13_1 SELEX + 24152423 24152435 1.0E-06 AAACAAACAAAAA 13 Foxj3_forkhead_DBD_dimeric_13_1 SELEX + 24152425 24152437 0.0E+00 ACAAACAAAAACA 13 TP63_p53l_DBD_dimeric_18_1 SELEX + 24156847 24156864 3.0E-06 CACATGTTGCAACATGGA 18 TP63_p53l_DBD_dimeric_18_1 SELEX - 24156847 24156864 2.0E-06 TCCATGTTGCAACATGTG 18 RREB1_MA0073.1 JASPAR + 24152418 24152437 1.0E-06 AAACCAAACAAACAAAAACA 20 V_FOXP1_01_M00987 TRANSFAC - 24152419 24152438 0.0E+00 ATGTTTTTGTTTGTTTGGTT 20 V_FOXP1_01_M00987 TRANSFAC - 24152423 24152442 9.0E-06 TTTCATGTTTTTGTTTGTTT 20 V_FOXP1_01_M00987 TRANSFAC - 24152425 24152444 3.0E-06 CTTTTCATGTTTTTGTTTGT 20 V_FOXP1_01_M00987 TRANSFAC - 24152427 24152446 2.0E-06 TTCTTTTCATGTTTTTGTTT 20 V_FOXP1_01_M00987 TRANSFAC - 24156821 24156840 9.0E-06 TTGTATATCTTTTCAAGAAT 20 V_BCL6_Q3_01_M02085 TRANSFAC - 24156822 24156831 9.0E-06 TTTTCAAGAA 10 V_FXR_Q3_M00631 TRANSFAC - 24151635 24151648 5.0E-06 GAGGTGGAGTGACT 14 V_BTEB3_Q5_M01865 TRANSFAC + 24152480 24152492 2.0E-06 GTGTGGGAGGTGT 13 V_YY1_02_M00069 TRANSFAC + 24151896 24151915 3.0E-06 TTGCTGCCATCTTGGCCCAG 20 V_ESR1_01_M02261 TRANSFAC + 24151610 24151629 0.0E+00 GTCCCAGGTCTCCATGACCC 20 V_STAT3STAT3_Q3_M01220 TRANSFAC + 24151684 24151697 2.0E-06 TTGAGGGGAAAAGG 14 V_EVI1_04_M00081 TRANSFAC + 24152433 24152447 2.0E-06 AAACATGAAAAGAAA 15 V_FOXD3_01_M00130 TRANSFAC - 24152423 24152434 1.0E-06 TTTTGTTTGTTT 12 V_BCL6_01_M01183 TRANSFAC - 24152432 24152447 9.0E-06 TTTCTTTTCATGTTTT 16 V_BCL6_01_M01183 TRANSFAC - 24156873 24156888 4.0E-06 TTAGCAGAATATTTTT 16 V_PROP1_01_M01294 TRANSFAC - 24152440 24152450 1.0E-05 TAATTTCTTTT 11 V_FOXJ2_02_M00423 TRANSFAC + 24152503 24152516 3.0E-06 ATATTAATAGTTAC 14 V_SP1_Q6_01_M00931 TRANSFAC - 24151975 24151984 4.0E-06 GGGGCGGGGC 10 V_EGR_Q6_M00807 TRANSFAC + 24151966 24151976 1.0E-05 GTGGGCGCGGC 11 V_CEBP_01_M00159 TRANSFAC - 24152446 24152458 1.0E-06 AATTTGGTTAATT 13 V_YY1_Q6_M00793 TRANSFAC + 24151901 24151909 7.0E-06 GCCATCTTG 9 V_HNF3_Q6_01_M01012 TRANSFAC - 24152419 24152436 0.0E+00 GTTTTTGTTTGTTTGGTT 18 V_GABPA_04_M02858 TRANSFAC - 24151683 24151698 3.0E-06 CCCTTTTCCCCTCAAA 16 V_SP1_03_M02281 TRANSFAC + 24151976 24151985 7.0E-06 CCCCGCCCCC 10 V_HFH4_01_M00742 TRANSFAC - 24152422 24152434 1.0E-06 TTTTGTTTGTTTG 13 V_SP1_02_M01303 TRANSFAC - 24151980 24151990 8.0E-06 GGGGCGGGGGC 11 V_LYF1_01_M00141 TRANSFAC + 24152132 24152140 3.0E-06 TTTGGGAGA 9 V_CDX_Q5_M00991 TRANSFAC + 24152424 24152441 1.0E-06 AACAAACAAAAACATGAA 18 V_MEF2A_Q6_M02024 TRANSFAC - 24156870 24156879 9.0E-06 TATTTTTAAG 10 V_TAL1_GATA1_01_M02243 TRANSFAC - 24156721 24156738 1.0E-05 TTGGCCATCACAGATAAT 18 V_LXRB_RXRA_Q5_M02021 TRANSFAC + 24152160 24152174 5.0E-06 TGAGGTCAGGAATTC 15 V_WT1_Q6_01_M02036 TRANSFAC + 24151979 24151988 4.0E-06 CGCCCCCGCC 10 V_RPC155_01_M01798 TRANSFAC + 24152165 24152180 0.0E+00 TCAGGAATTCGAGACC 16 V_HMBOX1_01_M01456 TRANSFAC - 24152444 24152460 4.0E-06 AGAATTTGGTTAATTTC 17 V_GC_01_M00255 TRANSFAC - 24151973 24151986 8.0E-06 CGGGGGCGGGGCCG 14 V_TCF3_04_M02816 TRANSFAC + 24152432 24152448 7.0E-06 AAAACATGAAAAGAAAT 17 V_ZFP105_03_M02827 TRANSFAC + 24152424 24152438 0.0E+00 AACAAACAAAAACAT 15 V_SREBP1_01_M00220 TRANSFAC + 24152153 24152163 8.0E-06 GATCACCTGAG 11 V_RUNX1_01_M02257 TRANSFAC + 24152457 24152467 8.0E-06 TTCTGTGGCTT 11 V_STAF_01_M00262 TRANSFAC + 24151907 24151928 2.0E-06 TTGGCCCAGAATCCCCCGCGGC 22 V_TEF_Q6_M00672 TRANSFAC + 24152509 24152520 7.0E-06 ATAGTTACACAA 12 V_KROX_Q6_M00982 TRANSFAC + 24151977 24151990 0.0E+00 CCCGCCCCCGCCCC 14 V_SP1_Q6_M00196 TRANSFAC - 24151974 24151986 1.0E-06 CGGGGGCGGGGCC 13 V_SP1_Q6_M00196 TRANSFAC - 24151980 24151992 9.0E-06 GAGGGGCGGGGGC 13 V_MAZ_Q6_01_M02023 TRANSFAC - 24151983 24151996 1.0E-05 GGCGGAGGGGCGGG 14 V_EGR1_Q6_M01873 TRANSFAC - 24151978 24151987 4.0E-06 GCGGGGGCGG 10 V_OCT1_04_M00138 TRANSFAC + 24152429 24152451 4.0E-06 ACAAAAACATGAAAAGAAATTAA 23 Tal1_Gata1_MA0140.1 JASPAR - 24156721 24156738 1.0E-05 TTGGCCATCACAGATAAT 18 V_TCF7_03_M02817 TRANSFAC + 24152432 24152448 2.0E-06 AAAACATGAAAAGAAAT 17 V_HFH1_01_M00129 TRANSFAC - 24152423 24152434 7.0E-06 TTTTGTTTGTTT 12 V_SMAD4_Q6_M00733 TRANSFAC - 24152008 24152022 3.0E-06 GGGGTGGAGCCAGCT 15 V_MZF1_02_M00084 TRANSFAC + 24151330 24151342 6.0E-06 GGGAGAGGGGAAA 13 V_SP4_Q5_M01273 TRANSFAC + 24151975 24151985 1.0E-06 GCCCCGCCCCC 11 V_HFH8_01_M00294 TRANSFAC - 24152422 24152434 5.0E-06 TTTTGTTTGTTTG 13 V_FAC1_01_M00456 TRANSFAC + 24152428 24152441 3.0E-06 AACAAAAACATGAA 14 V_OSR2_04_M02889 TRANSFAC + 24152561 24152576 7.0E-06 ATTTGCTACTCACTGT 16 V_CNOT3_01_M01253 TRANSFAC - 24151968 24151977 8.0E-06 GGCCGCGCCC 10 V_TCF1_06_M02815 TRANSFAC + 24152442 24152458 5.0E-06 AAGAAATTAACCAAATT 17 V_TCF4_Q5_M00671 TRANSFAC - 24151674 24151681 1.0E-05 CCTTTGAA 8 V_FOX_Q2_M00809 TRANSFAC - 24152422 24152434 2.0E-06 TTTTGTTTGTTTG 13 V_T3RBETA_Q6_01_M02119 TRANSFAC + 24152152 24152168 1.0E-06 AGATCACCTGAGGTCAG 17 V_TBX5_Q5_M01044 TRANSFAC - 24152486 24152495 9.0E-06 CTCACACCTC 10 V_LXRA_RXRA_Q3_M00647 TRANSFAC + 24152158 24152172 3.0E-06 CCTGAGGTCAGGAAT 15 V_DMRT2_01_M01147 TRANSFAC - 24156711 24156726 1.0E-06 GATAATGTTACTATGA 16 V_HFH3_01_M00289 TRANSFAC - 24152422 24152434 2.0E-06 TTTTGTTTGTTTG 13 V_FOXJ2_01_M00422 TRANSFAC + 24152419 24152436 2.0E-06 AACCAAACAAACAAAAAC 18 V_SP1_Q2_01_M00933 TRANSFAC + 24151976 24151985 4.0E-06 CCCCGCCCCC 10 V_SP1_Q2_01_M00933 TRANSFAC + 24151982 24151991 7.0E-06 CCCCGCCCCT 10 V_ARP1_01_M00155 TRANSFAC - 24152160 24152175 6.0E-06 CGAATTCCTGACCTCA 16 V_UF1H3BETA_Q6_M01068 TRANSFAC - 24151975 24151988 2.0E-06 GGCGGGGGCGGGGC 14 V_HMX3_02_M01413 TRANSFAC + 24152440 24152456 9.0E-06 AAAAGAAATTAACCAAA 17 V_SP1_Q4_01_M00932 TRANSFAC - 24151974 24151986 1.0E-06 CGGGGGCGGGGCC 13 V_TCF3_05_M02920 TRANSFAC + 24156867 24156881 6.0E-06 AACCTTAAAAATATT 15 V_ESR2_01_M02377 TRANSFAC - 24151614 24151631 1.0E-06 CTGGGTCATGGAGACCTG 18 V_T3RALPHA_Q6_M01724 TRANSFAC + 24152158 24152168 5.0E-06 CCTGAGGTCAG 11 V_ER_Q6_M00191 TRANSFAC + 24151613 24151631 6.0E-06 CCAGGTCTCCATGACCCAG 19

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.