Search TFs or Genes

Construction and Validation

Optimal Promoter Size

Download

Citation and Contact

PCSK9 Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 255738 proprotein convertase subtilisin/kexin type 9 chr1 + 55500148 - 55505648 55505148 Transcription Factor Binding Sites   Download all TFBS in the PCSK9 promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints HOXD12_homeodomain_DBD_monomeric_9_1 SELEX - 55500544 55500552 2.0E-06 CTAATAAAA 9 THRB_nuclearreceptor_DBD_dimeric_20_1 SELEX + 55501763 55501782 1.0E-06 TTGACCTTAGGTGTGGTCAT 20 THRB_nuclearreceptor_DBD_dimeric_20_1 SELEX - 55501763 55501782 1.0E-06 ATGACCACACCTAAGGTCAA 20 THRA_nuclearreceptor_FL_dimeric_18_1 SELEX - 55505473 55505490 5.0E-06 CTGTCCTGGCGAGGAGAC 18 SRF_MADS_DBD_dimeric_12_1 SELEX + 55502913 55502924 5.0E-06 TCCAAATAAGGT 12 SRF_MADS_DBD_dimeric_12_1 SELEX - 55502913 55502924 3.0E-06 ACCTTATTTGGA 12 NR2E1_nuclearreceptor_full_monomeric_9_1 SELEX - 55508876 55508884 2.0E-06 AAAAGTCAA 9 NR2F1_nuclearreceptor_DBD_monomeric_13_1 SELEX - 55501760 55501772 2.0E-06 CTAAGGTCAAATG 13 TBX5_TBX_DBD_dimeric_20_1 SELEX + 55500505 55500524 0.0E+00 AAGTGTAATATATGACACCC 20 TBX5_TBX_DBD_dimeric_20_1 SELEX - 55500505 55500524 0.0E+00 GGGTGTCATATATTACACTT 20 ESRRG_nuclearreceptor_full_dimeric_17_1 SELEX - 55506803 55506819 3.0E-06 AAGTTCACTCATGGTCA 17 HNF1B_MA0153.1 JASPAR + 55505126 55505137 0.0E+00 TTAATGTTTAAT 12 Lhx8_homeodomain_DBD_dimeric_12_1 SELEX - 55501744 55501755 9.0E-06 AAACTGCAATCA 12 RARG_nuclearreceptor_full_dimeric_17_1 SELEX - 55506803 55506819 6.0E-06 AAGTTCACTCATGGTCA 17 ZNF232_C2H2_full_monomeric_19_1 SELEX - 55500589 55500607 2.0E-06 CTGCAACATGTTGATTCAC 19 Rarb_nuclearreceptor_DBD_dimeric_18_1 SELEX - 55506803 55506820 5.0E-06 TAAGTTCACTCATGGTCA 18 RARA_nuclearreceptor_DBD_dimeric_18_2 SELEX + 55502875 55502892 2.0E-06 GAGATCCTTAGGTCAATT 18 SRF_MA0083.1 JASPAR - 55502914 55502925 3.0E-06 GACCTTATTTGG 12 THRB_nuclearreceptor_DBD_dimeric_18_1 SELEX - 55505473 55505490 4.0E-06 CTGTCCTGGCGAGGAGAC 18 LEF1_HMG_DBD_monomeric_15_1 SELEX + 55500527 55500541 8.0E-06 GCAGATCAAAGTGAG 15 HOXD11_homeodomain_DBD_monomeric_10_2 SELEX - 55500544 55500553 9.0E-06 TCTAATAAAA 10 ESRRG_nuclearreceptor_full_dimeric_18_1 SELEX - 55501753 55501770 8.0E-06 AAGGTCAAATGTAGGAAA 18 Esrra_nuclearreceptor_DBD_dimeric_17_1 SELEX - 55506803 55506819 2.0E-06 AAGTTCACTCATGGTCA 17 HOXC12_homeodomain_DBD_monomeric_9_1 SELEX - 55500544 55500552 7.0E-06 CTAATAAAA 9 RARG_nuclearreceptor_DBD_dimeric_17_2 SELEX - 55506803 55506819 6.0E-06 AAGTTCACTCATGGTCA 17 HOXD13_homeodomain_DBD_monomeric_10_1 SELEX - 55500543 55500552 2.0E-06 CTAATAAAAC 10 HNF1A_homeodomain_full_dimeric_15_1 SELEX + 55505124 55505138 5.0E-06 CGTTAATGTTTAATC 15 HNF1A_homeodomain_full_dimeric_15_1 SELEX - 55505124 55505138 0.0E+00 GATTAAACATTAACG 15 MGA_TBX_DBD_dimeric_18_2 SELEX + 55500506 55500523 1.0E-06 AGTGTAATATATGACACC 18 MGA_TBX_DBD_dimeric_18_2 SELEX - 55500506 55500523 1.0E-06 GGTGTCATATATTACACT 18 TBX4_TBX_DBD_dimeric_20_1 SELEX + 55500505 55500524 0.0E+00 AAGTGTAATATATGACACCC 20 TBX4_TBX_DBD_dimeric_20_1 SELEX - 55500505 55500524 0.0E+00 GGGTGTCATATATTACACTT 20 RARG_nuclearreceptor_DBD_dimeric_17_1 SELEX - 55506803 55506819 2.0E-06 AAGTTCACTCATGGTCA 17 TFAP2A_TFAP_DBD_dimeric_13_1 SELEX + 55504997 55505009 6.0E-06 AGCCCCTAGGGCG 13 HOXA13_homeodomain_full_monomeric_10_1 SELEX - 55500543 55500552 2.0E-06 CTAATAAAAC 10 HNF1B_homeodomain_full_dimeric_13_1 SELEX + 55505125 55505137 0.0E+00 GTTAATGTTTAAT 13 HNF1B_homeodomain_full_dimeric_13_1 SELEX - 55505125 55505137 2.0E-06 ATTAAACATTAAC 13 TBX15_TBX_DBD_dimeric_19_1 SELEX - 55500712 55500730 1.0E-05 GGGTGGGAAGTTTGCATCT 19 TBX2_TBX_full_dimeric_18_1 SELEX + 55500506 55500523 0.0E+00 AGTGTAATATATGACACC 18 TBX2_TBX_full_dimeric_18_1 SELEX - 55500506 55500523 0.0E+00 GGTGTCATATATTACACT 18 PRDM1_C2H2_full_monomeric-or-dimeric_15_1 SELEX + 55500532 55500546 3.0E-06 TCAAAGTGAGAGTTT 15 TFAP2B_TFAP_DBD_dimeric_13_1 SELEX + 55504997 55505009 9.0E-06 AGCCCCTAGGGCG 13 SRF_MADS_full_dimeric_16_1 SELEX + 55502911 55502926 0.0E+00 TTTCCAAATAAGGTCA 16 SRF_MADS_full_dimeric_16_1 SELEX - 55502911 55502926 2.0E-06 TGACCTTATTTGGAAA 16 HOXC13_homeodomain_DBD_monomeric_10_1 SELEX - 55500543 55500552 2.0E-06 CTAATAAAAC 10 TFAP2A_MA0003.1 JASPAR - 55505000 55505008 8.0E-06 GCCCTAGGG 9 RORA_nuclearreceptor_DBD_dimeric_20_1 SELEX - 55501753 55501772 2.0E-06 CTAAGGTCAAATGTAGGAAA 20 Nr2f6_nuclearreceptor_DBD_dimeric_15_1 SELEX + 55502875 55502889 2.0E-06 GAGATCCTTAGGTCA 15 HNF1B_homeodomain_full_dimeric_15_1 SELEX + 55505124 55505138 6.0E-06 CGTTAATGTTTAATC 15 HNF1B_homeodomain_full_dimeric_15_1 SELEX - 55505124 55505138 0.0E+00 GATTAAACATTAACG 15 DPRX_homeodomain_DBD_monomeric_11_1 SELEX + 55502859 55502869 4.0E-06 AGGATAATCTC 11 CDX2_homeodomain_DBD_monomeric_9_1 SELEX - 55500544 55500552 9.0E-06 CTAATAAAA 9 HOXB13_homeodomain_DBD_monomeric_10_1 SELEX - 55500543 55500552 2.0E-06 CTAATAAAAC 10 FOXO1_forkhead_DBD_dimeric_14_1 SELEX + 55500593 55500606 8.0E-06 ATCAACATGTTGCA 14 V_AP2ALPHA_01_M00469 TRANSFAC - 55505000 55505008 8.0E-06 GCCCTAGGG 9 V_HNF3B_01_M00131 TRANSFAC + 55505125 55505139 3.0E-06 GTTAATGTTTAATCA 15 V_AP1_Q2_M00173 TRANSFAC - 55508915 55508925 4.0E-06 GATGACTAAGT 11 V_LEF1_04_M02774 TRANSFAC - 55500526 55500542 6.0E-06 TCTCACTTTGATCTGCC 17 V_ZFP410_04_M02936 TRANSFAC - 55506221 55506237 6.0E-06 CCACCCCGCCCCTGTCT 17 V_NRSF_Q4_M01028 TRANSFAC - 55506330 55506348 5.0E-06 CCCCTGCCCCTTCAGCTGG 19 V_CEBP_Q3_M00770 TRANSFAC - 55502910 55502921 8.0E-06 TTATTTGGAAAT 12 V_SOX30_03_M02804 TRANSFAC - 55502765 55502780 8.0E-06 ATGTAACAATGGAGGC 16 V_HMGIY_Q3_M01010 TRANSFAC + 55506263 55506277 8.0E-06 GAGGCAATTTCTTTA 15 V_FOXD3_01_M00130 TRANSFAC + 55505127 55505138 8.0E-06 TAATGTTTAATC 12 V_IRF_Q6_01_M00972 TRANSFAC - 55502811 55502821 1.0E-05 AGAAGAGAAAG 11 V_MEIS1AHOXA9_01_M00420 TRANSFAC + 55500538 55500551 0.0E+00 TGAGAGTTTTATTA 14 V_CEBP_01_M00159 TRANSFAC - 55502908 55502920 3.0E-06 TATTTGGAAATGA 13 V_AP2_Q6_01_M00915 TRANSFAC + 55505178 55505190 9.0E-06 CGCGCCCCAGGCG 13 V_HOXD13_01_M01404 TRANSFAC - 55500540 55500555 0.0E+00 CCTCTAATAAAACTCT 16 V_AP1_Q6_M00174 TRANSFAC - 55508915 55508925 3.0E-06 GATGACTAAGT 11 V_SRF_C_M00215 TRANSFAC - 55502910 55502924 2.0E-06 ACCTTATTTGGAAAT 15 V_SRF_C_M00215 TRANSFAC + 55502913 55502927 3.0E-06 TCCAAATAAGGTCAC 15 V_TAL1_Q6_M00993 TRANSFAC + 55506303 55506312 3.0E-06 TCCATCTGTT 10 V_TBX18_01_M01262 TRANSFAC - 55500712 55500730 3.0E-06 GGGTGGGAAGTTTGCATCT 19 V_HOXB13_01_M01467 TRANSFAC - 55500540 55500555 6.0E-06 CCTCTAATAAAACTCT 16 V_MYCMAX_02_M00123 TRANSFAC + 55500731 55500742 6.0E-06 CACCACATGTCT 12 V_GATA3_05_M02859 TRANSFAC - 55502883 55502904 3.0E-06 CTTTGCAGATGTAATTGACCTA 22 V_XFD3_01_M00269 TRANSFAC - 55505126 55505139 7.0E-06 TGATTAAACATTAA 14 V_DOBOX4_01_M01359 TRANSFAC + 55501705 55501721 8.0E-06 CACAAATATACCCTTTC 17 V_AP1_Q4_M00188 TRANSFAC - 55508915 55508925 3.0E-06 GATGACTAAGT 11 V_HNF1B_04_M02266 TRANSFAC + 55505126 55505137 0.0E+00 TTAATGTTTAAT 12 V_MAZ_Q6_01_M02023 TRANSFAC - 55505417 55505430 5.0E-06 TGCGGTGGGGAGGA 14 V_MAZ_Q6_01_M02023 TRANSFAC + 55506230 55506243 5.0E-06 CGGGGTGGGAAGGA 14 V_IRF_Q6_M00772 TRANSFAC + 55502807 55502821 6.0E-06 TCCCCTTTCTCTTCT 15 V_HNF1_Q6_01_M01011 TRANSFAC + 55505121 55505141 4.0E-06 TTCCGTTAATGTTTAATCAGA 21 V_HNF1_Q6_01_M01011 TRANSFAC - 55505121 55505141 8.0E-06 TCTGATTAAACATTAACGGAA 21 V_SZF11_01_M01109 TRANSFAC - 55500746 55500760 8.0E-06 ACAGGGTATAGGAAG 15 V_SFPI1_04_M02896 TRANSFAC - 55505119 55505132 5.0E-06 ACATTAACGGAACC 14 V_MAFK_Q3_M02022 TRANSFAC + 55506997 55507007 3.0E-06 TTACTCAGCTC 11 V_SRF_Q5_02_M01007 TRANSFAC + 55502909 55502927 9.0E-06 CATTTCCAAATAAGGTCAC 19 V_SRF_Q5_02_M01007 TRANSFAC - 55502910 55502928 2.0E-06 TGTGACCTTATTTGGAAAT 19 V_SOX9_B1_M00410 TRANSFAC - 55502767 55502780 8.0E-06 ATGTAACAATGGAG 14 V_IRX5_01_M01472 TRANSFAC + 55500592 55500608 3.0E-06 AATCAACATGTTGCAGT 17 V_GATA4_Q3_M00632 TRANSFAC + 55500529 55500540 9.0E-06 AGATCAAAGTGA 12 V_GCNF_01_M00526 TRANSFAC - 55508869 55508886 5.0E-06 AGAAAAGTCAAGGCCACT 18 V_AML2_Q3_01_M01854 TRANSFAC + 55505199 55505209 6.0E-06 CCACACCCTAG 11 V_LEF1_Q2_01_M01022 TRANSFAC + 55500530 55500539 1.0E-06 GATCAAAGTG 10 V_HAND1E47_01_M00222 TRANSFAC + 55504952 55504967 4.0E-06 CTTGGAGTCTGGCATC 16 V_MYOD_Q6_01_M00929 TRANSFAC - 55506299 55506316 8.0E-06 CTGAAACAGATGGAATAC 18 V_SRF_01_M00152 TRANSFAC + 55502910 55502927 1.0E-06 ATTTCCAAATAAGGTCAC 18 V_SRF_01_M00152 TRANSFAC - 55502910 55502927 0.0E+00 GTGACCTTATTTGGAAAT 18 V_SIX4_01_M01374 TRANSFAC + 55500512 55500528 1.0E-06 ATATATGACACCCTGGC 17 V_MEF3_B_M00319 TRANSFAC - 55505095 55505107 6.0E-06 GGATCAGGTTTCG 13 V_SRF_Q5_01_M00922 TRANSFAC - 55502909 55502923 7.0E-06 CCTTATTTGGAAATG 15 V_SRF_Q5_01_M00922 TRANSFAC + 55502914 55502928 5.0E-06 CCAAATAAGGTCACA 15 V_SRF_Q4_M00810 TRANSFAC + 55502913 55502930 2.0E-06 TCCAAATAAGGTCACATT 18 V_TITF1_Q3_M00432 TRANSFAC + 55502794 55502803 4.0E-06 TCTCAAGTAT 10 V_IRX2_01_M01405 TRANSFAC + 55500592 55500608 5.0E-06 AATCAACATGTTGCAGT 17 V_SRF_02_M01257 TRANSFAC - 55502908 55502925 8.0E-06 GACCTTATTTGGAAATGA 18 V_SRF_02_M01257 TRANSFAC + 55502912 55502929 1.0E-06 TTCCAAATAAGGTCACAT 18 V_TBX22_01_M01195 TRANSFAC + 55500712 55500730 8.0E-06 AGATGCAAACTTCCCACCC 19 V_VDR_Q3_M00444 TRANSFAC + 55500569 55500583 7.0E-06 GGTGGAGCGGGGAGA 15 V_FOXO1_04_M01969 TRANSFAC - 55500593 55500612 8.0E-06 TCCGACTGCAACATGTTGAT 20 V_HOXD3_01_M01338 TRANSFAC - 55502884 55502899 5.0E-06 CAGATGTAATTGACCT 16 V_IRXB3_01_M01377 TRANSFAC + 55500592 55500608 7.0E-06 AATCAACATGTTGCAGT 17 V_ER_Q6_M00191 TRANSFAC - 55502882 55502900 6.0E-06 GCAGATGTAATTGACCTAA 19

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.