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ICOSLG Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 23308 inducible T-cell co-stimulator ligand chr21 - 45660334 - 45665834 45660834 Transcription Factor Binding Sites   Download all TFBS in the ICOSLG promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints CTCF_MA0139.1 JASPAR + 45663084 45663102 5.0E-06 GGGCCAGAAGGGGACACTG 19 KLF16_C2H2_DBD_monomeric_11_1 SELEX + 45660902 45660912 1.0E-05 GCCCCGCCCCC 11 SOX21_HMG_DBD_dimeric_13_2 SELEX - 45664529 45664541 4.0E-06 TGAATTTTATACA 13 TEF_bZIP_DBD_dimeric_12_1 SELEX - 45657316 45657327 4.0E-06 CCTTACATAACA 12 HLF_bZIP_full_dimeric_12_1 SELEX - 45657316 45657327 2.0E-06 CCTTACATAACA 12 EWSR1-FLI1_MA0149.1 JASPAR - 45660383 45660400 0.0E+00 GGAGGGAGGGAAGGCGGG 18 EWSR1-FLI1_MA0149.1 JASPAR - 45660387 45660404 0.0E+00 GGAAGGAGGGAGGGAAGG 18 EWSR1-FLI1_MA0149.1 JASPAR + 45661361 45661378 5.0E-06 GAATGGAAGGAGGGAGGG 18 EWSR1-FLI1_MA0149.1 JASPAR + 45661365 45661382 0.0E+00 GGAAGGAGGGAGGGAAAG 18 EWSR1-FLI1_MA0149.1 JASPAR + 45661369 45661386 5.0E-06 GGAGGGAGGGAAAGTGGG 18 EWSR1-FLI1_MA0149.1 JASPAR + 45663069 45663086 3.0E-06 GGCAGGAAGGCAGCTGGG 18 NFIL3_MA0025.1 JASPAR + 45657318 45657328 8.0E-06 TTATGTAAGGG 11 SOX7_HMG_full_dimeric_17_2 SELEX - 45664527 45664543 8.0E-06 TTTGAATTTTATACACA 17 EGR1_C2H2_full_monomeric_14_1 SELEX + 45660449 45660462 5.0E-06 CCCGCCCCCGCACG 14 RARA_nuclearreceptor_DBD_dimeric_18_2 SELEX - 45664119 45664136 5.0E-06 GAGGTCGTTAGTTCCAGC 18 DBP_bZIP_full_dimeric_12_1 SELEX + 45657316 45657327 8.0E-06 TGTTATGTAAGG 12 DBP_bZIP_full_dimeric_12_1 SELEX - 45657316 45657327 8.0E-06 CCTTACATAACA 12 TEAD1_TEA_full_monomeric_10_1 SELEX + 45663797 45663806 3.0E-06 TACATTCCTT 10 Sox17_HMG_DBD_dimeric_15_2 SELEX - 45664528 45664542 6.0E-06 TTGAATTTTATACAC 15 SOX2_HMG_full_dimeric_15_1 SELEX + 45664528 45664542 6.0E-06 GTGTATAAAATTCAA 15 SP1_MA0079.2 JASPAR + 45660436 45660445 7.0E-06 CCCCGCCCCC 10 SP1_MA0079.2 JASPAR + 45660903 45660912 7.0E-06 CCCCGCCCCC 10 Ascl2_bHLH_DBD_dimeric_10_1 SELEX + 45663566 45663575 6.0E-06 AGCAGCTGCC 10 SOX14_HMG_DBD_dimeric_13_1 SELEX - 45657368 45657380 1.0E-05 AAAATAACACTGA 13 SRY_MA0084.1 JASPAR - 45663779 45663787 1.0E-06 TTAAACAAT 9 SOX9_HMG_full_dimeric_16_3 SELEX - 45664092 45664107 1.0E-06 ACGAACATACAGTCAT 16 Egr3_C2H2_DBD_monomeric_15_1 SELEX + 45660449 45660463 9.0E-06 CCCGCCCCCGCACGG 15 Lhx3_MA0135.1 JASPAR + 45657214 45657226 5.0E-06 GAATTTATTAACA 13 SP1_C2H2_DBD_monomeric_11_1 SELEX + 45660435 45660445 4.0E-06 ACCCCGCCCCC 11 MZF1_5-13_MA0057.1 JASPAR - 45662117 45662126 4.0E-06 GGAGGGGGAA 10 NFIL3_bZIP_DBD_dimeric_12_1 SELEX - 45657316 45657327 3.0E-06 CCTTACATAACA 12 ID4_bHLH_DBD_dimeric_10_1 SELEX - 45664015 45664024 8.0E-06 TGCACCTGTT 10 Myf_MA0055.1 JASPAR + 45664152 45664163 5.0E-06 AAACAACAGCAG 12 PPARG_MA0066.1 JASPAR + 45663822 45663841 9.0E-06 TTAGGTGATTTTGTCCTTGT 20 TBX21_TBX_full_dimeric_19_1 SELEX - 45665120 45665138 6.0E-06 TGACACATAAATGGGGTTG 19 Sox3_HMG_DBD_dimeric_17_3 SELEX - 45664527 45664543 3.0E-06 TTTGAATTTTATACACA 17 TEAD4_TEA_DBD_monomeric_10_1 SELEX + 45663797 45663806 4.0E-06 TACATTCCTT 10 PLAG1_MA0163.1 JASPAR + 45661699 45661712 1.0E-06 GAGGCCCAGGGGGG 14 PLAG1_MA0163.1 JASPAR + 45662038 45662051 6.0E-06 GGGGGGATAGGGGG 14 Sox2_MA0143.1 JASPAR - 45659266 45659280 9.0E-06 CCTTTGACTTACAAA 15 Hic1_C2H2_DBD_dimeric_18_1 SELEX - 45660259 45660276 2.0E-06 AGGCCAGCTGGTGCCCAC 18 NFIA_NFI_full_monomeric_10_1 SELEX + 45659387 45659396 5.0E-06 TGTGCCAAGT 10 HNF1A_MA0046.1 JASPAR - 45657213 45657226 7.0E-06 TGTTAATAAATTCT 14 V_MEIS1BHOXA9_02_M00421 TRANSFAC + 45663255 45663268 1.0E-05 TGACATATACATGA 14 V_MEIS1BHOXA9_02_M00421 TRANSFAC - 45665125 45665138 3.0E-06 TGACACATAAATGG 14 V_AP2ALPHA_Q6_M01857 TRANSFAC + 45660906 45660916 6.0E-06 CGCCCCCGGCC 11 V_AP2ALPHA_Q6_M01857 TRANSFAC - 45661012 45661022 3.0E-06 CGCCTCCGGCC 11 V_STAT5A_Q6_M01890 TRANSFAC - 45663805 45663817 1.0E-06 GCATTTCTCAGAA 13 V_TST1_02_M01316 TRANSFAC + 45657211 45657227 6.0E-06 TCAGAATTTATTAACAA 17 V_DBX1_01_M01483 TRANSFAC - 45657211 45657227 8.0E-06 TTGTTAATAAATTCTGA 17 V_AREB6_03_M00414 TRANSFAC - 45664014 45664025 1.0E-06 CTGCACCTGTTC 12 V_PLAGL1_04_M02890 TRANSFAC + 45661093 45661109 5.0E-06 GGTGGGGGGTACCCGGC 17 V_OBOX1_01_M01450 TRANSFAC + 45662150 45662166 2.0E-06 TTGGGGGGATTTAAAAT 17 V_MTF1_Q4_M00650 TRANSFAC - 45662674 45662687 5.0E-06 GGTGCGCCCGGCCC 14 V_BCL6_01_M01183 TRANSFAC - 45658376 45658391 3.0E-06 TTTCTGGTTGTTTTTT 16 V_IK_Q5_M01169 TRANSFAC - 45662786 45662795 3.0E-06 TTTGGGAGGC 10 V_SP1_Q6_01_M00931 TRANSFAC + 45662180 45662189 4.0E-06 GGGGCGGGGC 10 V_EGR_Q6_M00807 TRANSFAC - 45661415 45661425 6.0E-06 GTGGGGGCGGG 11 V_YY1_Q6_M00793 TRANSFAC - 45659505 45659513 7.0E-06 GCCATCTTG 9 V_SP1_03_M02281 TRANSFAC + 45660436 45660445 7.0E-06 CCCCGCCCCC 10 V_SP1_03_M02281 TRANSFAC + 45660903 45660912 7.0E-06 CCCCGCCCCC 10 V_P50RELAP65_Q5_01_M01224 TRANSFAC - 45659289 45659300 6.0E-06 GGAGGTTCCCAC 12 V_AFP1_Q6_M00616 TRANSFAC - 45657371 45657381 7.0E-06 AAAAATAACAC 11 V_SP1_02_M01303 TRANSFAC - 45660434 45660444 8.0E-06 GGGGCGGGGTC 11 V_SP1_02_M01303 TRANSFAC - 45660885 45660895 8.0E-06 GGGGCGGGGAC 11 V_SP1_02_M01303 TRANSFAC - 45660896 45660906 8.0E-06 GGGGCGGGGAC 11 V_SP1_02_M01303 TRANSFAC + 45661091 45661101 5.0E-06 GGGGTGGGGGG 11 V_SP1_02_M01303 TRANSFAC + 45662185 45662195 8.0E-06 GGGGCGGGGGC 11 V_LYF1_01_M00141 TRANSFAC - 45662787 45662795 9.0E-06 TTTGGGAGG 9 V_AP4_Q6_01_M00927 TRANSFAC - 45661582 45661590 6.0E-06 ACCAGCTGC 9 V_ZFP691_03_M02833 TRANSFAC - 45664045 45664061 3.0E-06 GCCACAGTGCTCCCATA 17 V_TCFAP2E_04_M02926 TRANSFAC + 45658370 45658383 7.0E-06 GACTGGAAAAAACA 14 V_PAX_Q6_M00808 TRANSFAC + 45664120 45664130 0.0E+00 CTGGAACTAAC 11 V_STAT4_Q4_M01666 TRANSFAC - 45663756 45663769 8.0E-06 TTCCCCGAAGAGAA 14 V_NRSE_B_M00325 TRANSFAC - 45661278 45661298 6.0E-06 TGGAGATCATCGGAGCGCAGC 21 V_HES1_Q6_M02011 TRANSFAC + 45663924 45663933 6.0E-06 GCCACGAGCC 10 V_PAX5_02_M00144 TRANSFAC + 45660229 45660256 6.0E-06 CGTGTGTGGGGGAGGGCGTGTCCGCAGA 28 V_ETS_Q4_M00771 TRANSFAC - 45663561 45663572 1.0E-05 AGCTGCTTCCTG 12 V_FOXA2_02_M02853 TRANSFAC - 45657367 45657381 7.0E-06 AAAAATAACACTGAG 15 V_DBP_Q6_01_M01872 TRANSFAC + 45657318 45657325 5.0E-06 TTATGTAA 8 V_MYF_01_M01302 TRANSFAC + 45664152 45664163 5.0E-06 AAACAACAGCAG 12 V_GCM1_04_M02862 TRANSFAC + 45662039 45662055 4.0E-06 GGGGGATAGGGGGGACG 17 V_E4BP4_01_M00045 TRANSFAC + 45657316 45657327 2.0E-06 TGTTATGTAAGG 12 V_KROX_Q6_M00982 TRANSFAC + 45660437 45660450 5.0E-06 CCCGCCCCCGAGCC 14 V_KROX_Q6_M00982 TRANSFAC + 45660449 45660462 4.0E-06 CCCGCCCCCGCACG 14 V_KROX_Q6_M00982 TRANSFAC + 45661415 45661428 7.0E-06 CCCGCCCCCACCTA 14 V_RSRFC4_Q2_M00407 TRANSFAC + 45664002 45664018 6.0E-06 CATCTAAACATAGAACA 17 V_SP1_Q6_M00196 TRANSFAC - 45660901 45660913 2.0E-06 CGGGGGCGGGGCG 13 V_SP1_Q6_M00196 TRANSFAC + 45660950 45660962 8.0E-06 AGGAGGCGGGGCG 13 V_SP1_Q6_M00196 TRANSFAC + 45662178 45662190 6.0E-06 CAGGGGCGGGGCG 13 V_EGR1_Q6_M01873 TRANSFAC - 45660450 45660459 4.0E-06 GCGGGGGCGG 10 V_CDX2_Q5_M00729 TRANSFAC + 45657393 45657406 9.0E-06 CTACTTTTACTACT 14 V_OBOX2_01_M01364 TRANSFAC + 45662150 45662166 0.0E+00 TTGGGGGGATTTAAAAT 17 V_MEF2_03_M00232 TRANSFAC + 45663998 45664019 3.0E-06 AAGCCATCTAAACATAGAACAG 22 V_MATH1_Q2_M01716 TRANSFAC - 45660264 45660273 3.0E-06 CCAGCTGGTG 10 V_CDX1_01_M01373 TRANSFAC - 45657394 45657409 3.0E-06 AGAAGTAGTAAAAGTA 16 V_REX1_03_M01744 TRANSFAC + 45659506 45659517 7.0E-06 AAGATGGCTGTG 12 V_HBP1_03_M02762 TRANSFAC + 45661332 45661347 7.0E-06 GGAATGAATGACTGAA 16 V_GR_Q6_M00192 TRANSFAC - 45663841 45663859 2.0E-06 TGTGCACTCTGTGTTCACA 19 V_MEF2_Q6_01_M00941 TRANSFAC + 45657372 45657383 9.0E-06 TGTTATTTTTGT 12 V_STAT4_Q5_M02117 TRANSFAC + 45663805 45663814 5.0E-06 TTCTGAGAAA 10 V_PPARA_02_M00518 TRANSFAC + 45662037 45662055 9.0E-06 TGGGGGGATAGGGGGGACG 19 V_SP1_01_M00008 TRANSFAC - 45660435 45660444 3.0E-06 GGGGCGGGGT 10 V_SOX11_03_M02795 TRANSFAC - 45663432 45663448 3.0E-06 CCTAGAACAAAAGCCTA 17 V_CTCF_01_M01200 TRANSFAC + 45663083 45663102 7.0E-06 TGGGCCAGAAGGGGACACTG 20 V_BLIMP1_Q6_M01066 TRANSFAC + 45661370 45661385 1.0E-06 GAGGGAGGGAAAGTGG 16 V_AP1_Q2_01_M00924 TRANSFAC + 45663973 45663984 3.0E-06 TGACTCACTGGT 12 V_FOXO1_Q5_M01216 TRANSFAC + 45658377 45658385 5.0E-06 AAAAACAAC 9 V_SOX17_04_M02904 TRANSFAC - 45663260 45663276 6.0E-06 AGCCCCATTCATGTATA 17 V_HOXD9_Q2_M01834 TRANSFAC - 45665127 45665136 8.0E-06 ACACATAAAT 10 V_ZFP691_04_M02937 TRANSFAC + 45661712 45661728 6.0E-06 GACGTGACTCCCTTTCT 17 V_GLI3_01_M01596 TRANSFAC + 45664244 45664254 5.0E-06 CTGGGTGGCCC 11 V_ZNF515_01_M01231 TRANSFAC + 45661094 45661103 2.0E-06 GTGGGGGGTA 10 V_SP4_Q5_M01273 TRANSFAC + 45660902 45660912 1.0E-06 GCCCCGCCCCC 11 V_SP4_Q5_M01273 TRANSFAC - 45662179 45662189 8.0E-06 GCCCCGCCCCT 11 V_SP4_Q5_M01273 TRANSFAC - 45662184 45662194 7.0E-06 CCCCCGCCCCG 11 V_HAND1E47_01_M00222 TRANSFAC + 45663670 45663685 3.0E-06 TTTGGGGTCTGGCACA 16 V_OBOX2_02_M03064 TRANSFAC + 45662150 45662166 0.0E+00 TTGGGGGGATTTAAAAT 17 V_BRN4_01_M01473 TRANSFAC + 45657211 45657227 8.0E-06 TCAGAATTTATTAACAA 17 V_MYOD_Q6_01_M00929 TRANSFAC + 45664011 45664028 6.0E-06 ATAGAACAGGTGCAGTAA 18 V_TCFE2A_03_M02823 TRANSFAC + 45664012 45664028 4.0E-06 TAGAACAGGTGCAGTAA 17 V_HDX_01_M01333 TRANSFAC - 45663822 45663838 4.0E-06 AGGACAAAATCACCTAA 17 V_PITX1_01_M01484 TRANSFAC + 45662150 45662166 1.0E-06 TTGGGGGGATTTAAAAT 17 V_TFIIA_Q6_M00707 TRANSFAC + 45657319 45657330 2.0E-06 TATGTAAGGGGC 12 V_ZFP161_04_M02933 TRANSFAC - 45660958 45660971 4.0E-06 GCCGCGCAGCGCCC 14 V_ASCL2_04_M02841 TRANSFAC + 45660883 45660898 9.0E-06 GTGTCCCCGCCCCGTC 16 V_STAT1STAT1_Q3_M01212 TRANSFAC - 45663803 45663815 8.0E-06 ATTTCTCAGAAGG 13 V_RSRFC4_01_M00026 TRANSFAC - 45664002 45664017 8.0E-06 GTTCTATGTTTAGATG 16 V_E47_01_M00002 TRANSFAC - 45662191 45662205 1.0E-06 AGGGCAGGTGGCCCC 15 V_EGR1_06_M02744 TRANSFAC + 45660449 45660462 1.0E-06 CCCGCCCCCGCACG 14 V_SOX2_01_M02246 TRANSFAC - 45659266 45659280 9.0E-06 CCTTTGACTTACAAA 15 V_HFH3_01_M00289 TRANSFAC + 45663981 45663993 4.0E-06 TGGTATTTGTGTA 13 V_EWSR1FLI1_01_M02252 TRANSFAC - 45660383 45660400 0.0E+00 GGAGGGAGGGAAGGCGGG 18 V_EWSR1FLI1_01_M02252 TRANSFAC - 45660387 45660404 0.0E+00 GGAAGGAGGGAGGGAAGG 18 V_EWSR1FLI1_01_M02252 TRANSFAC + 45661361 45661378 5.0E-06 GAATGGAAGGAGGGAGGG 18 V_EWSR1FLI1_01_M02252 TRANSFAC + 45661365 45661382 0.0E+00 GGAAGGAGGGAGGGAAAG 18 V_EWSR1FLI1_01_M02252 TRANSFAC + 45661369 45661386 5.0E-06 GGAGGGAGGGAAAGTGGG 18 V_EWSR1FLI1_01_M02252 TRANSFAC + 45663069 45663086 3.0E-06 GGCAGGAAGGCAGCTGGG 18 V_HNF1A_Q5_M02013 TRANSFAC - 45657216 45657226 6.0E-06 TGTTAATAAAT 11 V_IRF1_01_M00062 TRANSFAC - 45657370 45657382 8.0E-06 CAAAAATAACACT 13 V_SRY_05_M02917 TRANSFAC - 45663774 45663790 1.0E-06 TCGTTAAACAATGTATG 17 V_FOXO4_01_M00472 TRANSFAC + 45658377 45658387 8.0E-06 AAAAACAACCA 11 V_SP1_Q4_01_M00932 TRANSFAC - 45660434 45660446 5.0E-06 CGGGGGCGGGGTC 13 V_SP1_Q4_01_M00932 TRANSFAC - 45660901 45660913 3.0E-06 CGGGGGCGGGGCG 13 V_SP1_Q4_01_M00932 TRANSFAC + 45662178 45662190 6.0E-06 CAGGGGCGGGGCG 13 V_HNF1A_01_M02162 TRANSFAC - 45657213 45657226 7.0E-06 TGTTAATAAATTCT 14 V_OBOX3_02_M03065 TRANSFAC + 45662150 45662166 3.0E-06 TTGGGGGGATTTAAAAT 17 V_OBOX3_01_M01466 TRANSFAC + 45662150 45662166 3.0E-06 TTGGGGGGATTTAAAAT 17 V_PAX6_01_M00097 TRANSFAC - 45657241 45657261 2.0E-06 GTTTTTCAAGTTTGACTGCAT 21 V_PAX6_01_M00097 TRANSFAC - 45661347 45661367 5.0E-06 TCCATTCATGCATGCGTTCAT 21 V_NANOG_02_M01247 TRANSFAC - 45657372 45657391 7.0E-06 GCTGAGTAACAAAAATAACA 20 V_HSF1_Q6_01_M02017 TRANSFAC - 45663208 45663221 4.0E-06 GAACTTTCTGGGGT 14

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.