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NLRP3 Entrez Description Chrom. Strand Promoter (Start - Stop) TSS 114548 NLR family, pyrin domain containing 3 chr1 + 247574457 - 247581850 247581350 Transcription Factor Binding Sites   Download all TFBS in the NLRP3 promoter   Motif Source Strand Start Stop PValue Match Sequence Overlap w/ Footprints HSF2_HSF_DBD_trimeric_13_1 SELEX + 247579636 247579648 0.0E+00 TTCTGGAATGTTC 13 SOX21_HMG_DBD_dimeric_15_1 SELEX - 247582794 247582808 9.0E-06 CACAATGTGAGTGTA 15 IRF7_IRF_DBD_dimeric_14_1 SELEX + 247582838 247582851 6.0E-06 GCAAAACTGAAACT 14 SPIC_ETS_full_monomeric_14_1 SELEX - 247581337 247581350 7.0E-06 AAAATGAGAAAGCA 14 SRY_HMG_DBD_dimeric_15_1 SELEX + 247582794 247582808 5.0E-06 TACACTCACATTGTG 15 Zfp652_C2H2_DBD_monomeric_13_1 SELEX - 247579366 247579378 6.0E-06 ACTAATGGTTAAT 13 SOX2_HMG_full_dimeric_17_1 SELEX + 247582793 247582809 6.0E-06 GTACACTCACATTGTGC 17 FOXG1_forkhead_DBD_dimeric_17_1 SELEX + 247579798 247579814 4.0E-06 ATATACAGAAGGAAACA 17 HSF1_HSF_full_trimeric_13_1 SELEX + 247579636 247579648 0.0E+00 TTCTGGAATGTTC 13 IRF8_IRF_full_dimeric_14_1 SELEX + 247582838 247582851 2.0E-06 GCAAAACTGAAACT 14 ZNF435_C2H2_full_dimeric_18_1 SELEX + 247581210 247581227 5.0E-06 TCTGTTATCAACACACTT 18 HNF1B_MA0153.1 JASPAR - 247579366 247579377 4.0E-06 CTAATGGTTAAT 12 Sox17_HMG_DBD_dimeric_15_1 SELEX + 247582794 247582808 9.0E-06 TACACTCACATTGTG 15 IRF1_MA0050.1 JASPAR - 247579147 247579158 6.0E-06 GGAAGTGAAACT 12 IRF1_MA0050.1 JASPAR + 247582840 247582851 1.0E-06 AAAACTGAAACT 12 NR4A2_nuclearreceptor_full_dimeric_17_1 SELEX - 247579564 247579580 8.0E-06 AGGACAAGTTCTGCCCT 17 NR2E1_nuclearreceptor_full_dimeric_14_1 SELEX + 247578975 247578988 2.0E-06 GAGTCAATGAGTCA 14 HSF4_HSF_DBD_trimeric_13_1 SELEX + 247579636 247579648 0.0E+00 TTCTGGAATGTTC 13 SOX14_HMG_DBD_dimeric_13_1 SELEX + 247582795 247582807 7.0E-06 ACACTCACATTGT 13 SOX14_HMG_DBD_dimeric_12_1 SELEX + 247582795 247582806 2.0E-06 ACACTCACATTG 12 TEAD3_TEA_DBD_dimeric_17_1 SELEX + 247578938 247578954 1.0E-06 ACATACCAGCCATTCCG 17 VENTX_homeodomain_DBD_dimeric_21_1 SELEX + 247579357 247579377 4.0E-06 AGCTATGTGATTAACCATTAG 21 LHX9_homeodomain_DBD_dimeric_13_1 SELEX + 247579364 247579376 8.0E-06 TGATTAACCATTA 13 LHX9_homeodomain_DBD_dimeric_13_1 SELEX - 247579364 247579376 6.0E-06 TAATGGTTAATCA 13 TEAD3_TEA_DBD_monomeric_8_1 SELEX - 247579639 247579646 1.0E-05 ACATTCCA 8 IRF9_IRF_full_trimeric_15_1 SELEX + 247582837 247582851 1.0E-06 TGCAAAACTGAAACT 15 Evi1_MA0029.1 JASPAR - 247584439 247584452 2.0E-06 AACACAAGACAAAA 14 SPDEF_ETS_full_putative-multimer_16_1 SELEX + 247575205 247575220 0.0E+00 GCAGTAAAAAGGAATA 16 TEAD1_TEA_full_dimeric_17_1 SELEX + 247578938 247578954 1.0E-06 ACATACCAGCCATTCCG 17 TEAD1_TEA_full_dimeric_17_1 SELEX + 247579449 247579465 6.0E-06 AAATTCATTGCATTTCC 17 TEAD1_TEA_full_dimeric_17_1 SELEX - 247579630 247579646 5.0E-06 ACATTCCAGAAATGTTG 17 IRF4_IRF_full_dimeric_15_1 SELEX + 247582838 247582852 2.0E-06 GCAAAACTGAAACTC 15 IRF5_IRF_full_dimeric_14_1 SELEX + 247582838 247582851 6.0E-06 GCAAAACTGAAACT 14 Sox1_HMG_DBD_dimeric_15_1 SELEX + 247582794 247582808 7.0E-06 TACACTCACATTGTG 15 Sox1_HMG_DBD_dimeric_15_1 SELEX - 247582794 247582808 7.0E-06 CACAATGTGAGTGTA 15 Foxj3_forkhead_DBD_dimeric_13_1 SELEX + 247575122 247575134 8.0E-06 AAAAACGGAAACA 13 NFIA_NFI_full_monomeric_10_1 SELEX + 247575116 247575125 9.0E-06 ATTGCCAAAA 10 IRF2_MA0051.1 JASPAR - 247579142 247579159 6.0E-06 GGGAAGTGAAACTAAGGA 18 V_NFAT_Q4_01_M00935 TRANSFAC + 247579346 247579355 5.0E-06 TTGGAAAATC 10 V_HOXA9_01_M01351 TRANSFAC + 247579441 247579457 5.0E-06 ACTGCTATAAATTCATT 17 V_FOXP1_01_M00987 TRANSFAC + 247584432 247584451 2.0E-06 TTCTTTCTTTTGTCTTGTGT 20 V_HSF2_01_M00147 TRANSFAC + 247579640 247579649 1.0E-05 GGAATGTTCT 10 V_OSR1_03_M02784 TRANSFAC + 247581279 247581294 6.0E-06 AAAAACAGAAGCAAAG 16 V_ER_Q6_02_M00959 TRANSFAC + 247579102 247579112 5.0E-06 CAGGTCATGCT 11 V_AML_Q6_M00769 TRANSFAC - 247579405 247579419 1.0E-06 AAGGATGTGGTCTCC 15 V_EBF_Q6_M00977 TRANSFAC - 247579775 247579785 1.0E-05 CTCCCCTGGGA 11 V_SOX14_05_M02902 TRANSFAC + 247575060 247575074 2.0E-06 CTTACACAATTGCAG 15 V_NF1_Q6_01_M00806 TRANSFAC + 247575109 247575125 3.0E-06 ATTGACGATTGCCAAAA 17 V_MEF2_02_M00231 TRANSFAC + 247579000 247579021 6.0E-06 TTGTGCTTTAAAAGTAGAACAT 22 V_DR4_Q2_M00965 TRANSFAC - 247584466 247584482 8.0E-06 TGCCCTTCTCTGAGCCC 17 V_IRF_Q6_01_M00972 TRANSFAC - 247579148 247579158 4.0E-06 GGAAGTGAAAC 11 V_IRF_Q6_01_M00972 TRANSFAC + 247581316 247581326 9.0E-06 GGAACTGAAAA 11 V_IRF_Q6_01_M00972 TRANSFAC + 247582840 247582850 1.0E-06 AAAACTGAAAC 11 V_IRF2_Q6_M01882 TRANSFAC - 247579145 247579160 0.0E+00 AGGGAAGTGAAACTAA 16 V_IRF2_Q6_M01882 TRANSFAC + 247582838 247582853 4.0E-06 GCAAAACTGAAACTCC 16 V_POU1F1_Q6_M00744 TRANSFAC - 247579447 247579456 8.0E-06 ATGAATTTAT 10 V_YY1_Q6_M00793 TRANSFAC + 247579049 247579057 7.0E-06 GCCATCTTG 9 V_IRF3_05_M02767 TRANSFAC + 247575122 247575135 2.0E-06 AAAAACGGAAACAG 14 V_MAF_Q6_M00648 TRANSFAC - 247579407 247579422 8.0E-06 AGGAAGGATGTGGTCT 16 V_NERF_Q2_M00531 TRANSFAC - 247579409 247579426 2.0E-06 GGGCAGGAAGGATGTGGT 18 V_PU1_Q4_M01172 TRANSFAC + 247579453 247579471 7.0E-06 TCATTGCATTTCCTCTCTA 19 V_PU1_Q4_M01172 TRANSFAC + 247581325 247581343 4.0E-06 AACATTCTCTTCTGCTTTC 19 V_PU1_Q4_M01172 TRANSFAC - 247581353 247581371 4.0E-06 AACTTCAGTTTCCTCATCT 19 V_HELIOSA_02_M01004 TRANSFAC + 247575211 247575221 1.0E-05 AAAAGGAATAA 11 V_HELIOSA_02_M01004 TRANSFAC + 247579344 247579354 4.0E-06 ATTTGGAAAAT 11 V_TCF3_04_M02816 TRANSFAC - 247579643 247579659 7.0E-06 TAATGATAAAAGAACAT 17 V_PR_Q2_M00960 TRANSFAC - 247579643 247579652 4.0E-06 AAAAGAACAT 10 V_PR_Q2_M00960 TRANSFAC - 247581175 247581184 3.0E-06 GAGAGAACAT 10 V_OCT1_03_M00137 TRANSFAC - 247579651 247579663 1.0E-05 CAAATAATGATAA 13 V_ZFP410_03_M02832 TRANSFAC + 247579789 247579805 5.0E-06 ATGGATGGGATATACAG 17 V_IRF2_01_M00063 TRANSFAC + 247582839 247582851 0.0E+00 CAAAACTGAAACT 13 V_CEBPD_Q6_M00621 TRANSFAC + 247582877 247582888 5.0E-06 CATTGCCTCATT 12 V_CEBPB_02_M00117 TRANSFAC + 247582833 247582846 1.0E-06 ATCTTGCAAAACTG 14 V_HNF1B_04_M02266 TRANSFAC - 247579366 247579377 4.0E-06 CTAATGGTTAAT 12 V_IRF3_Q3_M01279 TRANSFAC + 247579145 247579157 3.0E-06 TTAGTTTCACTTC 13 V_EVI1_01_M00078 TRANSFAC - 247584436 247584451 8.0E-06 ACACAAGACAAAAGAA 16 V_IRF_Q6_M00772 TRANSFAC + 247579144 247579158 0.0E+00 CTTAGTTTCACTTCC 15 V_ISRE_01_M00258 TRANSFAC + 247579146 247579160 0.0E+00 TAGTTTCACTTCCCT 15 V_ISRE_01_M00258 TRANSFAC - 247582838 247582852 0.0E+00 GAGTTTCAGTTTTGC 15 V_GR_01_M00955 TRANSFAC + 247584434 247584460 7.0E-06 CTTTCTTTTGTCTTGTGTTCTAGGCAA 27 V_SOX12_04_M02900 TRANSFAC - 247584435 247584450 8.0E-06 CACAAGACAAAAGAAA 16 V_MEF2_04_M00233 TRANSFAC + 247575113 247575134 7.0E-06 ACGATTGCCAAAAACGGAAACA 22 V_TCF7_03_M02817 TRANSFAC - 247579643 247579659 4.0E-06 TAATGATAAAAGAACAT 17 V_PBX1_05_M01967 TRANSFAC + 247575090 247575103 8.0E-06 CATGAGTGACAGTG 14 V_AP1_C_M00199 TRANSFAC + 247578981 247578989 3.0E-06 ATGAGTCAG 9 V_NKX3A_01_M00451 TRANSFAC - 247575193 247575204 6.0E-06 AGTTAAGTATTT 12 V_ISGF3G_03_M02771 TRANSFAC - 247579145 247579159 3.0E-06 GGGAAGTGAAACTAA 15 V_BLIMP1_Q6_M01066 TRANSFAC - 247579145 247579160 0.0E+00 AGGGAAGTGAAACTAA 16 V_ISGF4G_04_M02875 TRANSFAC - 247582820 247582833 5.0E-06 TGAAAACAGTTCTG 14 V_ICSBP_Q6_M00699 TRANSFAC - 247579146 247579157 0.0E+00 GAAGTGAAACTA 12 V_FOXO1_Q5_M01216 TRANSFAC + 247581279 247581287 1.0E-05 AAAAACAGA 9 V_IRF7_01_M00453 TRANSFAC + 247581357 247581374 4.0E-06 GAGGAAACTGAAGTTGAG 18 V_GR_Q6_02_M01836 TRANSFAC + 247581171 247581183 3.0E-06 TTTTATGTTCTCT 13 V_HBP1_04_M02866 TRANSFAC + 247581339 247581355 9.0E-06 CTTTCTCATTTTGTAGA 17 V_ZFP105_04_M02931 TRANSFAC + 247579621 247579637 5.0E-06 GTGCTTCAACAACATTT 17 V_TBP_01_M00471 TRANSFAC + 247579446 247579453 8.0E-06 TATAAATT 8 V_FAC1_01_M00456 TRANSFAC - 247584440 247584453 4.0E-06 GAACACAAGACAAA 14 V_SMAD4_04_M02898 TRANSFAC - 247579692 247579708 4.0E-06 TTCCCCCCGCCACATAC 17 V_AREB6_02_M00413 TRANSFAC - 247578967 247578978 1.0E-06 ACTCACCTGTTC 12 V_ZSCAN4_04_M02942 TRANSFAC - 247584442 247584457 9.0E-06 CCTAGAACACAAGACA 16 V_AIRE_01_M00999 TRANSFAC - 247575172 247575197 3.0E-06 TATTTCATGGGTTGGATAGGCCACAA 26 V_GATA6_01_M00462 TRANSFAC - 247579649 247579658 6.0E-06 AATGATAAAA 10 V_NKX22_01_M00485 TRANSFAC - 247575193 247575202 2.0E-06 TTAAGTATTT 10 V_OSR2_03_M02785 TRANSFAC + 247581279 247581294 7.0E-06 AAAAACAGAAGCAAAG 16 V_PADS_C_M00211 TRANSFAC - 247579406 247579414 4.0E-06 TGTGGTCTC 9 V_ZBTB12_03_M02824 TRANSFAC + 247584445 247584461 9.0E-06 CTTGTGTTCTAGGCAAA 17 V_BBX_03_M02739 TRANSFAC + 247579449 247579463 6.0E-06 AAATTCATTGCATTT 15 V_BBX_03_M02739 TRANSFAC - 247579449 247579463 5.0E-06 AAATGCAATGAATTT 15 V_IRF1_Q6_01_M01881 TRANSFAC + 247579146 247579159 2.0E-06 TAGTTTCACTTCCC 14 V_IRF1_Q6_01_M01881 TRANSFAC - 247581315 247581328 9.0E-06 TGTTTTCAGTTCCT 14 V_IRF1_Q6_01_M01881 TRANSFAC - 247582839 247582852 2.0E-06 GAGTTTCAGTTTTG 14 V_SOX14_04_M02901 TRANSFAC + 247579786 247579802 7.0E-06 AAGATGGATGGGATATA 17 V_HSF2_02_M01244 TRANSFAC - 247579636 247579648 0.0E+00 GAACATTCCAGAA 13 V_SOX1_03_M02802 TRANSFAC + 247579446 247579461 1.0E-06 TATAAATTCATTGCAT 16 V_IRF1_01_M00062 TRANSFAC + 247582839 247582851 0.0E+00 CAAAACTGAAACT 13 V_TCF11MAFG_01_M00284 TRANSFAC - 247581331 247581352 1.0E-06 ACAAAATGAGAAAGCAGAAGAG 22 V_CEBPG_Q6_01_M01869 TRANSFAC - 247582802 247582813 8.0E-06 GGTTGCACAATG 12 V_NANOG_02_M01247 TRANSFAC - 247584433 247584452 3.0E-06 AACACAAGACAAAAGAAAGA 20 V_HSF1_Q6_01_M02017 TRANSFAC - 247579635 247579648 3.0E-06 GAACATTCCAGAAA 14

Need help? Please contact cplaisier(at)systemsbiology.org if you have any questions, comments or concerns. Developed at the Institute for Systems Biology in the Baliga Lab.